Estimating the proportion of variation in susceptibility to schizophrenia captured by common SNPs

S Hong Lee, Teresa R DeCandia, Stephan Ripke, Jian Yang, Patrick F Sullivan, Michael E Goddard, Matthew C Keller, Peter M Visscher, Naomi R Wray, Schizophrenia Psychiatric Genome-Wide Association Study Consortium (PGC-SCZ), Thomas Folkmann Hansen, Andrés Ingason, Line Olsen, Henrik Berg Rasmussen, Thomas Mears Werge

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Abstract

Schizophrenia is a complex disorder caused by both genetic and environmental factors. Using 9,087 affected individuals, 12,171 controls and 915,354 imputed SNPs from the Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium (PGC-SCZ), we estimate that 23% (s.e. = 1%) of variation in liability to schizophrenia is captured by SNPs. We show that a substantial proportion of this variation must be the result of common causal variants, that the variance explained by each chromosome is linearly related to its length (r = 0.89, P = 2.6 × 10(-8)), that the genetic basis of schizophrenia is the same in males and females, and that a disproportionate proportion of variation is attributable to a set of 2,725 genes expressed in the central nervous system (CNS; P = 7.6 × 10(-8)). These results are consistent with a polygenic genetic architecture and imply more individual SNP associations will be detected for this disease as sample size increases.
OriginalsprogEngelsk
TidsskriftNature Genetics
Vol/bind44
Udgave nummer3
Sider (fra-til)247-50
Antal sider4
ISSN1061-4036
DOI
StatusUdgivet - 2012

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