Evaluating neurocognitive outcomes in out-of-hospital cardiac arrest survivors: A comparative study of performance-based and reported measures

Mie Klarskov Jensen, Jan Christensen, Pardis Zarifkar, Lau Caspar Thygesen, Anders Wieghorst, Selina Kikkenborg Berg, Christian Hassager, Dea Siggaard Stenbæk, Mette Kirstine Wagner*

*Corresponding author af dette arbejde

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Abstract

Aims
To (1) describe the prevalence of cognitive dysfunctions using performance-based and reported measures, and (2) explore the correlations between selected performance-based, patient-reported, and observer-reported neurocognitive outcome measures three months after hospital discharge in a population of out-of-hospital cardiac arrest (OHCA) survivors.
Methods
Data from 193 OHCA survivors was derived from the Danish multicenter REVIVAL cohort study. At three months, four subtests of the performance-based Delis-Kaplan Executive Function System (D-KEFS) (Trail making, Color-word interference, Verbal fluency, and Figure design), the patient-reported Behavior Rating Inventory of Executive Function − Adult (BRIEF-A), and the observer-reported 16-item Short Form (SF) Informant Questionnaire on Cognitive Decline after Cardiac Arrest (SF-16 IQCODE-CA) were collected. Spearman’s rank coefficient correlation analysis was performed to examine correlations between D-KEFS, BRIEF-A, and SF-16 IQCODE-CA.
Results
Overall, 21% of survivors exhibited impairment in executive functioning using the D-KEFS subtest Color-word interference, while only 9% self-reported executive impairment (BRIEF-A) and 7% of relatives reported cognitive decline (SF-16 IQCODE-CA) in survivors at three months post-arrest. All correlations between D-KEFS, BRIEF-A and SF-16 IQCODE-CA were negligible to low.
Conclusion
The results of this REVIVAL substudy suggest that although the performance-based and reported measures did not correlate, dual neurocognitive screening tools containing both a self-reported and an informant-reported version may have the potential to detect executive discrepancies in the return to everyday life and guide targeted neurorehabilitation after OHCA.
OriginalsprogEngelsk
Artikelnummer110310
TidsskriftResuscitation
Vol/bind202
Antal sider10
ISSN0300-9572
DOI
StatusUdgivet - 2024

Bibliografisk note

Funding Information:
Organisation and financing of the project: The authors disclose receipt of the following financial support for the research, authorship and/or publication of this article: This project was performed as a part of a master project and supported by the Nordea-Fund, grant no. 02-2013-0200.

Publisher Copyright:
© 2024 The Author(s)

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