@article{b7b07f20b18f11ddb04f000ea68e967b,
title = "Evidence for a Na+-Ca2+ exchanger in rat pancreatic ducts.",
abstract = "Only recently has it been recognized that intracellular Ca2+ is an important cellular mediator in pancreatic ducts. The aim of the present study was to characterize the Ca2+ efflux pathway in ducts freshly prepared from rat pancreas. Lowering of extracellular Na+ concentration resulted in a significant increase in intracellular Ca2+. This effect was fast, reversible, dependent on the extracellular Na+ concentration and did not correlate with intracellular pH changes. It was abolished in Ca2+-free solutions, indicating that the outwardly directed Na+ gradient was directly coupled to a flufenamate insensitive Ca2+ influx. Removal and reintroduction of extracellular Na+ induced transient hyperpolarization and depolarization of Vm, respectively. Taken together, our data indicate that pancreatic ducts possess an electrogenic Na+-Ca2+ exchanger, which under control conditions is responsible for transporting Ca2+ out of resting duct cells.",
author = "M Hug and C Pahl and I Novak",
note = "Keywords: Acetates; Animals; Bepridil; Biological Transport; Calcium; Calcium Channel Blockers; Carrier Proteins; Female; Flufenamic Acid; Guanidines; Hydrogen-Ion Concentration; Membrane Potentials; Pancreatic Ducts; Rats; Rats, Wistar; Sodium; Sodium-Calcium Exchanger",
year = "1996",
language = "English",
volume = "397",
pages = "298--302",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "JohnWiley & Sons Ltd",
number = "2-3",
}