Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Journal of Experimental Medicine |
| Vol/bind | 200 |
| Udgave nummer | 9 |
| Sider (fra-til) | 1197-203 |
| Antal sider | 6 |
| ISSN | 0022-1007 |
| DOI | |
| Status | Udgivet - 2004 |
Bibliografisk note
Keywords: Africa; Birth Weight; Chondroitin Sulfates; DNA Primers; Enzyme-Linked Immunosorbent Assay; Erythrocytes; Female; Humans; Immunoglobulin G; Malaria, Falciparum; Male; Microscopy, Confocal; Placenta; Pregnancy; Protozoan Proteins; Recombinant Proteins; Sex FactorsAdgang til dokumentet
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Evidence for the involvement of VAR2CSA in pregnancy-associated malaria. / Salanti, Ali; Dahlbäck, Madeleine; Turner, Louise; Nielsen, Morten A; Barfod, Lea; Magistrado, Pamela; Jensen, Anja T R; Lavstsen, Thomas; Ofori, Michael F; Marsh, Kevin; Hviid, Lars; Theander, Thor G.
I: Journal of Experimental Medicine, Bind 200, Nr. 9, 2004, s. 1197-203.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Evidence for the involvement of VAR2CSA in pregnancy-associated malaria
AU - Salanti, Ali
AU - Dahlbäck, Madeleine
AU - Turner, Louise
AU - Nielsen, Morten A
AU - Barfod, Lea
AU - Magistrado, Pamela
AU - Jensen, Anja T R
AU - Lavstsen, Thomas
AU - Ofori, Michael F
AU - Marsh, Kevin
AU - Hviid, Lars
AU - Theander, Thor G
N1 - Keywords: Africa; Birth Weight; Chondroitin Sulfates; DNA Primers; Enzyme-Linked Immunosorbent Assay; Erythrocytes; Female; Humans; Immunoglobulin G; Malaria, Falciparum; Male; Microscopy, Confocal; Placenta; Pregnancy; Protozoan Proteins; Recombinant Proteins; Sex Factors
PY - 2004
Y1 - 2004
N2 - In Plasmodium falciparum-endemic areas, pregnancy-associated malaria (PAM) is an important health problem. The condition is precipitated by accumulation of parasite-infected erythrocytes (IEs) in the placenta, and this process is mediated by parasite-encoded variant surface antigens (VSA) binding to chondroitin sulfate A (CSA). Parasites causing PAM express unique VSA types, VSAPAM, which can be serologically classified as sex specific and parity dependent. It is sex specific because men from malaria-endemic areas do not develop VSAPAM antibodies; it is parity dependent because women acquire anti-VSAPAM immunoglobulin (Ig) G as a function of parity. Previously, it was shown that transcription of var2csa is up-regulated in placental parasites and parasites selected for CSA binding. Here, we show the following: (a) that VAR2CSA is expressed on the surface of CSA-selected IEs; (b) that VAR2CSA is recognized by endemic plasma in a sex-specific and parity-dependent manner; (c) that high anti-VAR2CSA IgG levels can be found in pregnant women from both West and East Africa; and (d) that women with high plasma levels of anti-VAR2CSA IgG give birth to markedly heavier babies and have a much lower risk of delivering low birth weight children than women with low levels.
AB - In Plasmodium falciparum-endemic areas, pregnancy-associated malaria (PAM) is an important health problem. The condition is precipitated by accumulation of parasite-infected erythrocytes (IEs) in the placenta, and this process is mediated by parasite-encoded variant surface antigens (VSA) binding to chondroitin sulfate A (CSA). Parasites causing PAM express unique VSA types, VSAPAM, which can be serologically classified as sex specific and parity dependent. It is sex specific because men from malaria-endemic areas do not develop VSAPAM antibodies; it is parity dependent because women acquire anti-VSAPAM immunoglobulin (Ig) G as a function of parity. Previously, it was shown that transcription of var2csa is up-regulated in placental parasites and parasites selected for CSA binding. Here, we show the following: (a) that VAR2CSA is expressed on the surface of CSA-selected IEs; (b) that VAR2CSA is recognized by endemic plasma in a sex-specific and parity-dependent manner; (c) that high anti-VAR2CSA IgG levels can be found in pregnant women from both West and East Africa; and (d) that women with high plasma levels of anti-VAR2CSA IgG give birth to markedly heavier babies and have a much lower risk of delivering low birth weight children than women with low levels.
U2 - 10.1084/jem.20041579
DO - 10.1084/jem.20041579
M3 - Journal article
C2 - 15520249
VL - 200
SP - 1197
EP - 1203
JO - The Journal of Experimental Medicine
JF - The Journal of Experimental Medicine
SN - 0022-1007
IS - 9
ER -