Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity

G Andersen; L Wegner; K Yanagisawa; C S Rose; J Lin; C Glümer; T Drivsholm; K Borch-Johnsen; T Jørgensen; T Hansen; B M Spiegelman; O Pedersen

doi:10.1136/jmg.2004.026278

Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity

G Andersen, L Wegner, K Yanagisawa, C S Rose, J Lin, C Glümer, T Drivsholm, K Borch-Johnsen, T Jørgensen, T Hansen, B M Spiegelman, O Pedersen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

52 Citationer (Scopus)

Abstract

Peroxisome proliferator activated receptor-gamma coactivator-1beta (PGC-1beta) is a recently identified homologue of the tissue specific coactivator PGC-1alpha, a coactivator of transcription factors such as the peroxisome proliferators activated receptors and nuclear respiratory factors. PGC-1alpha is involved in adipogenesis, mitochondrial biogenesis, fatty acid beta oxidation, and hepatic gluconeogenesis.

Originalsprog	Engelsk
Tidsskrift	Journal of Medical Genetics
Vol/bind	42
Udgave nummer	5
Sider (fra-til)	402-7
Antal sider	6
ISSN	1468-6244
DOI	https://doi.org/10.1136/jmg.2004.026278
Status	Udgivet - 1 maj 2005

Adgang til dokumentet

10.1136/jmg.2004.026278

Biblioteksadgang?

Tjek tilgængelighed hos det Kgl. Bibliotek

Citationsformater

@article{f91133816c904080bf0018254787c427,

title = "Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity",

abstract = "Peroxisome proliferator activated receptor-gamma coactivator-1beta (PGC-1beta) is a recently identified homologue of the tissue specific coactivator PGC-1alpha, a coactivator of transcription factors such as the peroxisome proliferators activated receptors and nuclear respiratory factors. PGC-1alpha is involved in adipogenesis, mitochondrial biogenesis, fatty acid beta oxidation, and hepatic gluconeogenesis.",

keywords = "Aged, Carrier Proteins, DNA Mutational Analysis, Denmark, Diabetes Mellitus, Type 2, Gene Frequency, Genetic Testing, Genetic Variation, Genotype, Glucose, Humans, Linkage Disequilibrium, Middle Aged, Mutation, Obesity",

author = "G Andersen and L Wegner and K Yanagisawa and Rose, {C S} and J Lin and C Gl{\"u}mer and T Drivsholm and K Borch-Johnsen and T J{\o}rgensen and T Hansen and Spiegelman, {B M} and O Pedersen",

year = "2005",

month = may,

day = "1",

doi = "10.1136/jmg.2004.026278",

language = "English",

volume = "42",

pages = "402--7",

journal = "Journal of Medical Genetics",

issn = "1468-6244",

publisher = "B M J Group",

number = "5",

}

TY - JOUR

T1 - Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity

AU - Andersen, G

AU - Wegner, L

AU - Yanagisawa, K

AU - Rose, C S

AU - Lin, J

AU - Glümer, C

AU - Drivsholm, T

AU - Borch-Johnsen, K

AU - Jørgensen, T

AU - Hansen, T

AU - Spiegelman, B M

AU - Pedersen, O

PY - 2005/5/1

Y1 - 2005/5/1

N2 - Peroxisome proliferator activated receptor-gamma coactivator-1beta (PGC-1beta) is a recently identified homologue of the tissue specific coactivator PGC-1alpha, a coactivator of transcription factors such as the peroxisome proliferators activated receptors and nuclear respiratory factors. PGC-1alpha is involved in adipogenesis, mitochondrial biogenesis, fatty acid beta oxidation, and hepatic gluconeogenesis.

AB - Peroxisome proliferator activated receptor-gamma coactivator-1beta (PGC-1beta) is a recently identified homologue of the tissue specific coactivator PGC-1alpha, a coactivator of transcription factors such as the peroxisome proliferators activated receptors and nuclear respiratory factors. PGC-1alpha is involved in adipogenesis, mitochondrial biogenesis, fatty acid beta oxidation, and hepatic gluconeogenesis.

KW - Aged

KW - Carrier Proteins

KW - DNA Mutational Analysis

KW - Denmark

KW - Diabetes Mellitus, Type 2

KW - Gene Frequency

KW - Genetic Testing

KW - Genetic Variation

KW - Genotype

KW - Glucose

KW - Humans

KW - Linkage Disequilibrium

KW - Middle Aged

KW - Mutation

KW - Obesity

U2 - 10.1136/jmg.2004.026278

DO - 10.1136/jmg.2004.026278

M3 - Journal article

C2 - 15863669

SN - 1468-6244

VL - 42

SP - 402

EP - 407

JO - Journal of Medical Genetics

JF - Journal of Medical Genetics

IS - 5

ER -