TY - JOUR
T1 - Exercise training alters the balance between vasoactive compounds in skeletal muscle of individuals with essential hypertension
AU - Hansen, Ane Håkansson
AU - Nyberg, Michael Permin
AU - Bangsbo, Jens
AU - Saltin, Bengt
AU - Hellsten, Ylva
N1 - CURIS 2011 5200 089
PY - 2011
Y1 - 2011
N2 - The effects of physical training on the formation of vasodilating and vasoconstricting compounds, as well as on related proteins important for vascular function, were examined in skeletal muscle of individuals with essential hypertension (n=10). Muscle microdialysis samples were obtained from subjects with hypertension before and after 16 weeks of physical training. Muscle dialysates were analyzed for thromboxane A(2), prostacyclin, nucleotides, and nitrite/nitrate. Protein levels of thromboxane synthase, prostacyclin synthase, cyclooxygenase 1 and 2, endothelial nitric oxide synthase (eNOS), cystathionine-¿-lyase, cytochrome P450 4A and 2C9, and the purinergic receptors P2X1 and P2Y2 were determined in skeletal muscle. The protein levels were compared with those of normotensive control subjects (n=12). Resting muscle dialysate thromboxane A(2) and prostacyclin concentrations were lower (P
AB - The effects of physical training on the formation of vasodilating and vasoconstricting compounds, as well as on related proteins important for vascular function, were examined in skeletal muscle of individuals with essential hypertension (n=10). Muscle microdialysis samples were obtained from subjects with hypertension before and after 16 weeks of physical training. Muscle dialysates were analyzed for thromboxane A(2), prostacyclin, nucleotides, and nitrite/nitrate. Protein levels of thromboxane synthase, prostacyclin synthase, cyclooxygenase 1 and 2, endothelial nitric oxide synthase (eNOS), cystathionine-¿-lyase, cytochrome P450 4A and 2C9, and the purinergic receptors P2X1 and P2Y2 were determined in skeletal muscle. The protein levels were compared with those of normotensive control subjects (n=12). Resting muscle dialysate thromboxane A(2) and prostacyclin concentrations were lower (P
U2 - 10.1161/HYPERTENSIONAHA.111.176529
DO - 10.1161/HYPERTENSIONAHA.111.176529
M3 - Journal article
C2 - 21896936
VL - 58
SP - 943
EP - 949
JO - Hypertension
JF - Hypertension
SN - 0194-911X
IS - 5
ER -