Exercise training improves blood flow to contracting skeletal muscle of older men via enhanced cGMP signaling

Peter Bergmann Piil, Tue Smith Jørgensen, Jon Egelund, Rasmus Damsgaard, Lasse Gliemann, Ylva Hellsten, Michael Permin Nyberg

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

12 Citationer (Scopus)

Abstract

Physical activity has the potential to offset age-related impairments in the regulation of blood flow and O2 delivery to the exercising muscles; however, the mechanisms underlying this effect of physical activity remain poorly understood. The present study examined the role of cGMP in training-induced adaptations in the regulation of skeletal muscle blood flow and oxidative metabolism during exercise in aging humans. We measured leg hemodynamics and oxidative metabolism during exercise engaging the knee-extensor muscles in young (n=15, 25 ± 1 years) and older (n=15, 72 ± 1 years) subjects before and after a period of aerobic high-intensity exercise training. To determine the role of cGMP signaling, pharmacological inhibition of phosphodiesterase 5 (PDE5) was performed. Before training, inhibition of PDE5 increased (P<0.05) skeletal muscle blood flow and VO2 during moderate-intensity exercise in the older group; however, these effects of PDE5 inhibition were not detected after training. These findings suggest a role for enhanced cGMP signaling in the training-induced improvement of regulation of blood flow in contracting skeletal muscle of older men.

OriginalsprogEngelsk
TidsskriftJournal of Applied Physiology
Vol/bind124
Udgave nummer1
Sider (fra-til)109-117
Antal sider9
ISSN8750-7587
DOI
StatusUdgivet - 2018

Bibliografisk note

CURIS 2018 NEXS 044

Citationsformater