TY - JOUR
T1 - Exploring hepatic hormone actions using a compilation of gene expression profiles
AU - Ståhlberg, Nina
AU - Merino, Roxana
AU - Hernández, Luis Henríquez
AU - Fernández-Pérez, Leandro
AU - Sandelin, Albin
AU - Engström, Pär
AU - Tollet-Egnell, Petra
AU - Lenhard, Boris
AU - Flores Morales, Amilcar
PY - 2005
Y1 - 2005
N2 - Microarray analysis is attractive within the field of endocrine research because regulation of gene expression is a key mechanism whereby hormones exert their actions. Knowledge discovery and testing of hypothesis based on information-rich expression profiles promise to accelerate discovery of physiologically relevant hormonal mechanisms of action. However, most studies so-far concentrate on the analysis of actions of single hormones and few examples exist that attempt to use compilation of different hormone-regulated expression profiles to gain insight into how hormone act to regulate tissue physiology. This report illustrates how a meta-analysis of multiple transcript profiles obtained from a single tissue, the liver, can be used to evaluate relevant hypothesis and discover novel mechanisms of hormonal action. We have evaluated the differential effects of Growth Hormone (GH) and estrogen in the regulation of hepatic gender differentiated gene expression as well as the involvement of sterol regulatory element-binding proteins (SREBPs) in the hepatic actions of GH and thyroid hormone.
AB - Microarray analysis is attractive within the field of endocrine research because regulation of gene expression is a key mechanism whereby hormones exert their actions. Knowledge discovery and testing of hypothesis based on information-rich expression profiles promise to accelerate discovery of physiologically relevant hormonal mechanisms of action. However, most studies so-far concentrate on the analysis of actions of single hormones and few examples exist that attempt to use compilation of different hormone-regulated expression profiles to gain insight into how hormone act to regulate tissue physiology. This report illustrates how a meta-analysis of multiple transcript profiles obtained from a single tissue, the liver, can be used to evaluate relevant hypothesis and discover novel mechanisms of hormonal action. We have evaluated the differential effects of Growth Hormone (GH) and estrogen in the regulation of hepatic gender differentiated gene expression as well as the involvement of sterol regulatory element-binding proteins (SREBPs) in the hepatic actions of GH and thyroid hormone.
U2 - 10.1186/1472-6793-5-8
DO - 10.1186/1472-6793-5-8
M3 - Journal article
C2 - 15953391
VL - 5
SP - 8
JO - B M C Physiology
JF - B M C Physiology
SN - 1472-6793
IS - 1
ER -