Exploring hepatic hormone actions using a compilation of gene expression profiles

Nina Ståhlberg, Roxana Merino, Luis Henríquez Hernández, Leandro Fernández-Pérez, Albin Sandelin, Pär Engström, Petra Tollet-Egnell, Boris Lenhard, Amilcar Flores Morales

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

38 Citationer (Scopus)

Abstract

Microarray analysis is attractive within the field of endocrine research because regulation of gene expression is a key mechanism whereby hormones exert their actions. Knowledge discovery and testing of hypothesis based on information-rich expression profiles promise to accelerate discovery of physiologically relevant hormonal mechanisms of action. However, most studies so-far concentrate on the analysis of actions of single hormones and few examples exist that attempt to use compilation of different hormone-regulated expression profiles to gain insight into how hormone act to regulate tissue physiology. This report illustrates how a meta-analysis of multiple transcript profiles obtained from a single tissue, the liver, can be used to evaluate relevant hypothesis and discover novel mechanisms of hormonal action. We have evaluated the differential effects of Growth Hormone (GH) and estrogen in the regulation of hepatic gender differentiated gene expression as well as the involvement of sterol regulatory element-binding proteins (SREBPs) in the hepatic actions of GH and thyroid hormone.
OriginalsprogEngelsk
TidsskriftBMC Physiology
Vol/bind5
Udgave nummer1
Sider (fra-til)8
ISSN1472-6793
DOI
StatusUdgivet - 2005
Udgivet eksterntJa

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