Expression of metastasin S100A4 is essential for bone resorption and regulates osteoclast function

Malin C Erlandsson, M Svensson, Ing-Marie Jonsson, Li Bian, Noona Ambartsumian, Sofia Andersson, Zhiqi Peng, Jukka Vääräniemi, Claes Ohlsson, Karin M E Andersson, Maria I Bokarewa

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23 Citationer (Scopus)

Abstract

S100A4 is a Ca-binding protein that regulates cell growth, survival, and motility. The abundant expression of S100A4 in rheumatiod arthritis contributes to the invasive growth of joint tissue and to bone damage. In the present study, we analysed the role of S100A4 in bone homeostasis.
OriginalsprogEngelsk
TidsskriftBBA General Subjects
Vol/bind1833
Udgave nummer12
Sider (fra-til)2653-2663
Antal sider11
ISSN0304-4165
DOI
StatusUdgivet - 2 jul. 2013

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