@article{bb43dbf0a75c11debc73000ea68e967b,
title = "Expression of protein-coding genes embedded in ribosomal DNA",
abstract = "Ribosomal DNA (rDNA) is a specialised chromosomal location that is dedicated to high-level transcription of ribosomal RNA genes. Interestingly, rDNAs are frequently interrupted by parasitic elements, some of which carry protein genes. These are non-LTR retrotransposons and group II introns that encode reverse transcriptase-like genes, and group I introns and archaeal introns that encode homing endonuclease genes (HEGs). Although rDNA-embedded protein genes are widespread in nuclei, organelles and bacteria, there is surprisingly little information available on how these genes are expressed. Exceptions include a handful of HEGs from group I introns. Recent studies have revealed unusual and essential roles of group I and group I-like ribozymes in the endogenous expression of HEGs. Here we discuss general aspects of rDNA-embedded protein genes and focus on HEG expression from group I introns in the nucleolus.",
author = "Johansen, {Steinar D} and Peik Haugen and Henrik Nielsen",
note = "Keywords: Animals; Cell Nucleus; DNA Transposable Elements; DNA, Ribosomal; Gene Expression Regulation; Introns; Proteins",
year = "2007",
doi = "10.1515/BC.2007.089",
language = "English",
volume = "388",
pages = "679--86",
journal = "Biological Chemistry",
issn = "1431-6730",
publisher = "Walterde Gruyter GmbH",
number = "7",
}