Expression of the vitamin D receptor, 25-hydroxylases, 1alpha-hydroxylase and 24-hydroxylase in the human kidney and renal clear cell cancer

Martin Blomberg Jensen; Claus B. Andersen; John E Nielsen; Per Bagi; Anne Jørgensen; Anders Juul; Henrik Leffers

doi:10.1016/j.jsbmb.2010.03.069

Expression of the vitamin D receptor, 25-hydroxylases, 1alpha-hydroxylase and 24-hydroxylase in the human kidney and renal clear cell cancer

Martin Blomberg Jensen, Claus B. Andersen, John E Nielsen, Per Bagi, Anne Jørgensen, Anders Juul, Henrik Leffers

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

72 Citationer (Scopus)

Abstract

The vitamin D receptor (VDR), CYP27B1 and CYP24A1 are expressed in the human kidney, but the segmental expression of the 25-hydroxylases is unknown. A comprehensive analysis of CYP2R1, CYP27A1, CYP27B1, VDR and CYP24A1 expression in normal kidney and renal clear cell cancer (CCc) would reveal the segmental location of expression, and clarify whether the reported loss of VDR in CCc is coincident with alterations of vitamin D metabolism.

Originalsprog	Engelsk
Tidsskrift	Journal of Steroid Biochemistry and Molecular Biology
Vol/bind	121
Udgave nummer	1-2
Sider (fra-til)	376-82
Antal sider	7
ISSN	0960-0760
DOI	https://doi.org/10.1016/j.jsbmb.2010.03.069
Status	Udgivet - 1 jul. 2010

Adgang til dokumentet

10.1016/j.jsbmb.2010.03.069

Citationsformater

Blomberg Jensen, M., Andersen, C. B., Nielsen, J. E., Bagi, P., Jørgensen, A., Juul, A., & Leffers, H. (2010). Expression of the vitamin D receptor, 25-hydroxylases, 1alpha-hydroxylase and 24-hydroxylase in the human kidney and renal clear cell cancer. Journal of Steroid Biochemistry and Molecular Biology, 121(1-2), 376-82. https://doi.org/10.1016/j.jsbmb.2010.03.069

Expression of the vitamin D receptor, 25-hydroxylases, 1alpha-hydroxylase and 24-hydroxylase in the human kidney and renal clear cell cancer. / Blomberg Jensen, Martin; Andersen, Claus B.; Nielsen, John E et al.
I: Journal of Steroid Biochemistry and Molecular Biology, Bind 121, Nr. 1-2, 01.07.2010, s. 376-82.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Blomberg Jensen, M, Andersen, CB, Nielsen, JE, Bagi, P, Jørgensen, A, Juul, A & Leffers, H 2010, 'Expression of the vitamin D receptor, 25-hydroxylases, 1alpha-hydroxylase and 24-hydroxylase in the human kidney and renal clear cell cancer', Journal of Steroid Biochemistry and Molecular Biology, bind 121, nr. 1-2, s. 376-82. https://doi.org/10.1016/j.jsbmb.2010.03.069

@article{16331295428840a1a3d0991aa90be04b,

title = "Expression of the vitamin D receptor, 25-hydroxylases, 1alpha-hydroxylase and 24-hydroxylase in the human kidney and renal clear cell cancer",

abstract = "The vitamin D receptor (VDR), CYP27B1 and CYP24A1 are expressed in the human kidney, but the segmental expression of the 25-hydroxylases is unknown. A comprehensive analysis of CYP2R1, CYP27A1, CYP27B1, VDR and CYP24A1 expression in normal kidney and renal clear cell cancer (CCc) would reveal the segmental location of expression, and clarify whether the reported loss of VDR in CCc is coincident with alterations of vitamin D metabolism.",

author = "{Blomberg Jensen}, Martin and Andersen, {Claus B.} and Nielsen, {John E} and Per Bagi and Anne J{\o}rgensen and Anders Juul and Henrik Leffers",

year = "2010",

month = jul,

day = "1",

doi = "10.1016/j.jsbmb.2010.03.069",

language = "English",

volume = "121",

pages = "376--82",

journal = "Journal of Steroid Biochemistry and Molecular Biology",

issn = "0960-0760",

publisher = "Pergamon Press",

number = "1-2",

}

TY - JOUR

T1 - Expression of the vitamin D receptor, 25-hydroxylases, 1alpha-hydroxylase and 24-hydroxylase in the human kidney and renal clear cell cancer

AU - Blomberg Jensen, Martin

AU - Andersen, Claus B.

AU - Nielsen, John E

AU - Bagi, Per

AU - Jørgensen, Anne

AU - Juul, Anders

AU - Leffers, Henrik

PY - 2010/7/1

Y1 - 2010/7/1

N2 - The vitamin D receptor (VDR), CYP27B1 and CYP24A1 are expressed in the human kidney, but the segmental expression of the 25-hydroxylases is unknown. A comprehensive analysis of CYP2R1, CYP27A1, CYP27B1, VDR and CYP24A1 expression in normal kidney and renal clear cell cancer (CCc) would reveal the segmental location of expression, and clarify whether the reported loss of VDR in CCc is coincident with alterations of vitamin D metabolism.

AB - The vitamin D receptor (VDR), CYP27B1 and CYP24A1 are expressed in the human kidney, but the segmental expression of the 25-hydroxylases is unknown. A comprehensive analysis of CYP2R1, CYP27A1, CYP27B1, VDR and CYP24A1 expression in normal kidney and renal clear cell cancer (CCc) would reveal the segmental location of expression, and clarify whether the reported loss of VDR in CCc is coincident with alterations of vitamin D metabolism.

U2 - 10.1016/j.jsbmb.2010.03.069

DO - 10.1016/j.jsbmb.2010.03.069

M3 - Journal article

SN - 0960-0760

VL - 121

SP - 376

EP - 382

JO - Journal of Steroid Biochemistry and Molecular Biology

JF - Journal of Steroid Biochemistry and Molecular Biology

IS - 1-2

ER -