TY - JOUR
T1 - Fasting and postprandial serum concentrations of glycine- and taurine-conjugated bile acids in crohn's disease
AU - Linnet, K.
AU - Nielsen, A. Mertz
PY - 1983/1/1
Y1 - 1983/1/1
N2 - Fasting and postprandial serum concentrations of glycine and taurine conjugates of cholic, chenodeoxycholic, and deoxycholic acid were measured with a high-pressure liquid chromatographic-enzymatic assay in 17 patients with ileal Crohn's disease and in 17 controls. The postprandial concentrations of the taurine-conjugated bile acids in the patients were significantly lower than in the controls, whereas the concentrations of the glycine conjugates were not significantly different. The total glycine to taurine ratios of serum bile acids were significantly higher in the patients (means, 2.9 fasting and 4.8 postprandial) than in the controls (1.9 and 2.6). Of the patients, 65% had a postprandial total G/T ratio of serum bile acids which was above the control interval.
AB - Fasting and postprandial serum concentrations of glycine and taurine conjugates of cholic, chenodeoxycholic, and deoxycholic acid were measured with a high-pressure liquid chromatographic-enzymatic assay in 17 patients with ileal Crohn's disease and in 17 controls. The postprandial concentrations of the taurine-conjugated bile acids in the patients were significantly lower than in the controls, whereas the concentrations of the glycine conjugates were not significantly different. The total glycine to taurine ratios of serum bile acids were significantly higher in the patients (means, 2.9 fasting and 4.8 postprandial) than in the controls (1.9 and 2.6). Of the patients, 65% had a postprandial total G/T ratio of serum bile acids which was above the control interval.
KW - Crohn's disease
KW - Glycine- and taurine-conjugated bile acids, serum
UR - http://www.scopus.com/inward/record.url?scp=0020522149&partnerID=8YFLogxK
U2 - 10.3109/00365528309181619
DO - 10.3109/00365528309181619
M3 - Journal article
C2 - 6673068
AN - SCOPUS:0020522149
VL - 18
SP - 433
EP - 438
JO - Scandinavian Journal of Gastroenterology. Supplement
JF - Scandinavian Journal of Gastroenterology. Supplement
SN - 0085-5928
IS - 3
ER -