First-in-man open clinical trial of a combined rdESAT-6 and rCFP-10 tuberculosis specific skin test reagent

Winnie Bergstedt; Pernille N Tingskov; Birgit Thierry-Carstensen; Søren T Hoff; Henrik Aggerbeck; Vibeke Thomsen; Peter Andersen; Åse Bengård Andersen

doi:10.1371/journal.pone.0011277

First-in-man open clinical trial of a combined rdESAT-6 and rCFP-10 tuberculosis specific skin test reagent

Winnie Bergstedt, Pernille N Tingskov, Birgit Thierry-Carstensen, Søren T Hoff, Henrik Aggerbeck, Vibeke Thomsen, Peter Andersen, Åse Bengård Andersen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

36 Citationer (Scopus)

Abstract

Tuberculin is still the only available skin test reagent for the diagnosis of mycobacterial infection. The product has a remarkable sensitivity, but poor specificity. Previous studies, including two human phase I clinical trials, have indicated that rdESAT-6 has a potential as an improved skin test reagent. Animal studies have shown that the sensitivity may be increased by inclusion of the genetically related CFP-10 antigen in the preparation without loosing specificity.

Originalsprog	Engelsk
Tidsskrift	P L o S One
Vol/bind	5
Udgave nummer	6
Sider (fra-til)	e11277
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0011277
Status	Udgivet - 1 jan. 2010

Adgang til dokumentet

10.1371/journal.pone.0011277

Citationsformater

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AU - Bergstedt, Winnie

AU - Tingskov, Pernille N

AU - Thierry-Carstensen, Birgit

AU - Hoff, Søren T

AU - Aggerbeck, Henrik

AU - Thomsen, Vibeke

AU - Andersen, Peter

AU - Andersen, Åse Bengård

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AB - Tuberculin is still the only available skin test reagent for the diagnosis of mycobacterial infection. The product has a remarkable sensitivity, but poor specificity. Previous studies, including two human phase I clinical trials, have indicated that rdESAT-6 has a potential as an improved skin test reagent. Animal studies have shown that the sensitivity may be increased by inclusion of the genetically related CFP-10 antigen in the preparation without loosing specificity.

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