First total synthesis of (+/-)-3-hydroxy-11-norcytisine: Structure confirmation and biological characterization

Daniel Yohannes; Camilla Petrycer Hansen; Srinivasa Rao Akireddy; Terry A Hauser; Melanie N Kiser; Nicholas J Gurnon; Cynthia S Day; Balwinder Bhatti; William S Caldwell

doi:10.1021/ol802145b

First total synthesis of (+/-)-3-hydroxy-11-norcytisine: Structure confirmation and biological characterization

Daniel Yohannes, Camilla Petrycer Hansen, Srinivasa Rao Akireddy, Terry A Hauser, Melanie N Kiser, Nicholas J Gurnon, Cynthia S Day, Balwinder Bhatti, William S Caldwell

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

10 Citationer (Scopus)

Abstract

The first total synthesis of the natural product 3-hydroxy-11-norcytisine ( 1), structurally related to cytisine ( 2), a benchmark ligand at neuronal nicotinic acetylcholine receptors (NNRs), has been achieved. The synthesis permits the unambiguous confirmation of the structure originally proposed for 1 and has enabled initial biological characterization of 1 and its related compounds against NNRs.

Originalsprog	Engelsk
Tidsskrift	Organic Letters
Vol/bind	10
Udgave nummer	23
Sider (fra-til)	5353-5356
ISSN	1523-7060
DOI	https://doi.org/10.1021/ol802145b
Status	Udgivet - 2008

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Det tidligere Farmaceutiske Fakultet

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10.1021/ol802145b

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Citationsformater

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abstract = "The first total synthesis of the natural product 3-hydroxy-11-norcytisine ( 1), structurally related to cytisine ( 2), a benchmark ligand at neuronal nicotinic acetylcholine receptors (NNRs), has been achieved. The synthesis permits the unambiguous confirmation of the structure originally proposed for 1 and has enabled initial biological characterization of 1 and its related compounds against NNRs.",

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T1 - First total synthesis of (+/-)-3-hydroxy-11-norcytisine

T2 - Structure confirmation and biological characterization

AU - Yohannes, Daniel

AU - Hansen, Camilla Petrycer

AU - Akireddy, Srinivasa Rao

AU - Hauser, Terry A

AU - Kiser, Melanie N

AU - Gurnon, Nicholas J

AU - Day, Cynthia S

AU - Bhatti, Balwinder

AU - Caldwell, William S

PY - 2008

Y1 - 2008

N2 - The first total synthesis of the natural product 3-hydroxy-11-norcytisine ( 1), structurally related to cytisine ( 2), a benchmark ligand at neuronal nicotinic acetylcholine receptors (NNRs), has been achieved. The synthesis permits the unambiguous confirmation of the structure originally proposed for 1 and has enabled initial biological characterization of 1 and its related compounds against NNRs.

AB - The first total synthesis of the natural product 3-hydroxy-11-norcytisine ( 1), structurally related to cytisine ( 2), a benchmark ligand at neuronal nicotinic acetylcholine receptors (NNRs), has been achieved. The synthesis permits the unambiguous confirmation of the structure originally proposed for 1 and has enabled initial biological characterization of 1 and its related compounds against NNRs.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1021/ol802145b

DO - 10.1021/ol802145b

M3 - Journal article

C2 - 19007172

SN - 1523-7060

VL - 10

SP - 5353

EP - 5356

JO - Organic Letters

JF - Organic Letters

IS - 23

ER -