TY - JOUR
T1 - First total synthesis of type II abyssomicins
T2 - (±)-abyssomicin 2 and (±)-neoabyssomicin B
AU - Canko, Aleksander
AU - Athanassopoulou, Georgia D.
AU - Psycharis, Vassilis
AU - Raptopoulou, Catherine P.
AU - Herniman, Julie M.
AU - Mouchtouris, Vasileios
AU - Foscolos, Angeliki Sofia
AU - Couladouros, Elias A.
AU - Vidali, Veroniki P.
N1 - Funding Information:
This research is co-financed by Greece and the European Union (European Social Fund- ESF) through the Operational Programme “Human Resources Development, Education and Lifelong Learning” in the context of the project “Strengthening Human Resources Research Potential via Doctorate Research – 2 Cycle” (MIS-5000432), implemented by the State Scholarships Foundation (IKY). nd
Publisher Copyright:
© 2023 The Royal Society of Chemistry.
PY - 2023
Y1 - 2023
N2 - The intramolecular Diels-Alder reaction (IMDA) of a butenolide derivative, as an entry to the type II abyssomicin scaffold, and the total synthesis of (±)-abyssomicin 2 and (±)-neoabyssomicin B are reported for the first time. A facile route to the IMDA precursor, the formation of a type I intermediate and two paths to (±)-neoabyssomicin B are also discussed.
AB - The intramolecular Diels-Alder reaction (IMDA) of a butenolide derivative, as an entry to the type II abyssomicin scaffold, and the total synthesis of (±)-abyssomicin 2 and (±)-neoabyssomicin B are reported for the first time. A facile route to the IMDA precursor, the formation of a type I intermediate and two paths to (±)-neoabyssomicin B are also discussed.
U2 - 10.1039/d3ob00476g
DO - 10.1039/d3ob00476g
M3 - Letter
C2 - 37083981
AN - SCOPUS:85153799794
VL - 21
SP - 3761
EP - 3765
JO - Organic & Biomolecular Chemistry
JF - Organic & Biomolecular Chemistry
SN - 1470-4358
IS - 18
ER -