First total synthesis of type II abyssomicins: (±)-abyssomicin 2 and (±)-neoabyssomicin B

Aleksander Canko, Georgia D. Athanassopoulou, Vassilis Psycharis, Catherine P. Raptopoulou, Julie M. Herniman, Vasileios Mouchtouris, Angeliki Sofia Foscolos, Elias A. Couladouros, Veroniki P. Vidali*

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftLetterForskningpeer review

8 Downloads (Pure)

Abstract

The intramolecular Diels-Alder reaction (IMDA) of a butenolide derivative, as an entry to the type II abyssomicin scaffold, and the total synthesis of (±)-abyssomicin 2 and (±)-neoabyssomicin B are reported for the first time. A facile route to the IMDA precursor, the formation of a type I intermediate and two paths to (±)-neoabyssomicin B are also discussed.

OriginalsprogEngelsk
TidsskriftOrganic and Biomolecular Chemistry
Vol/bind21
Udgave nummer18
Sider (fra-til)3761–3765
Antal sider5
ISSN1477-0520
DOI
StatusUdgivet - 2023

Bibliografisk note

Publisher Copyright:
© 2023 The Royal Society of Chemistry.

Citationsformater