Fish oil supplementation in pregnancy and neurodevelopment in childhood - A randomized clinical trial

Laerke Sass; Elín Bjarnadóttir; Jakob Stokholm; Bo Chawes; Rebecca K Vinding; Anna-Rosa C Mora-Jensen; Jonathan Thorsen; Sarah Nørgaard; Bjørn H Ebdrup; Jens R M Jepsen; Birgitte Fagerlund; Klaus Bønnelykke; Lotte Lauritzen; Hans Bisgaard

doi:10.1111/cdev.13541

Fish oil supplementation in pregnancy and neurodevelopment in childhood - A randomized clinical trial

Laerke Sass, Elín Bjarnadóttir, Jakob Stokholm, Bo Chawes, Rebecca K Vinding, Anna-Rosa C Mora-Jensen, Jonathan Thorsen, Sarah Nørgaard, Bjørn H Ebdrup, Jens R M Jepsen, Birgitte Fagerlund, Klaus Bønnelykke, Lotte Lauritzen, Hans Bisgaard^*

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

12 Citationer (Scopus)

Abstract

A double-blind randomized controlled trial of n-3 long-chain polyunsaturated fatty acid (n-3 LCPUFA) supplementation or matching placebo during third trimester of pregnancy was conducted within the COPSAC₂₀₁₀ mother-child cohort consisting of 736 women and their children. The objective was to determine if maternal n-3 LCPUFA pregnancy supplementation affects offspring neurodevelopment until 6 years. Neurodevelopment was evaluated in 654 children assessing age of motor milestone achievement, language development, cognitive development, general neurodevelopment, and emotional and behavioral problems. Maternal n-3 LCPUFA supplementation during pregnancy improved early language development and reduced the impact of emotional and behavioral problems. The n-3 LCPUFA supplementation was in boys associated with the earlier achievement of gross motor milestones, improved cognitive development, and a reduced impact of emotional and behavioral problems.

Originalsprog	Engelsk
Tidsskrift	Child Development
Vol/bind	92
Udgave nummer	4
Sider (fra-til)	1624-1635
Antal sider	12
ISSN	0009-3920
DOI	https://doi.org/10.1111/cdev.13541
Status	Udgivet - 2021

Bibliografisk note

CURIS 2021 NEXS 040

Adgang til dokumentet

10.1111/cdev.13541

Citationsformater

Sass, L., Bjarnadóttir, E., Stokholm, J., Chawes, B., Vinding, R. K., Mora-Jensen, A.-R. C., Thorsen, J., Nørgaard, S., Ebdrup, B. H., Jepsen, J. R. M., Fagerlund, B., Bønnelykke, K., Lauritzen, L., & Bisgaard, H. (2021). Fish oil supplementation in pregnancy and neurodevelopment in childhood - A randomized clinical trial. Child Development, 92(4), 1624-1635. https://doi.org/10.1111/cdev.13541

Sass, L, Bjarnadóttir, E , Stokholm, J , Chawes, B, Vinding, RK, Mora-Jensen, A-RC, Thorsen, J, Nørgaard, S, Ebdrup, BH, Jepsen, JRM, Fagerlund, B , Bønnelykke, K , Lauritzen, L & Bisgaard, H 2021, 'Fish oil supplementation in pregnancy and neurodevelopment in childhood - A randomized clinical trial', Child Development, bind 92, nr. 4, s. 1624-1635. https://doi.org/10.1111/cdev.13541

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title = "Fish oil supplementation in pregnancy and neurodevelopment in childhood - A randomized clinical trial",

abstract = "A double-blind randomized controlled trial of n-3 long-chain polyunsaturated fatty acid (n-3 LCPUFA) supplementation or matching placebo during third trimester of pregnancy was conducted within the COPSAC2010 mother-child cohort consisting of 736 women and their children. The objective was to determine if maternal n-3 LCPUFA pregnancy supplementation affects offspring neurodevelopment until 6 years. Neurodevelopment was evaluated in 654 children assessing age of motor milestone achievement, language development, cognitive development, general neurodevelopment, and emotional and behavioral problems. Maternal n-3 LCPUFA supplementation during pregnancy improved early language development and reduced the impact of emotional and behavioral problems. The n-3 LCPUFA supplementation was in boys associated with the earlier achievement of gross motor milestones, improved cognitive development, and a reduced impact of emotional and behavioral problems.",

author = "Laerke Sass and El{\'i}n Bjarnad{\'o}ttir and Jakob Stokholm and Bo Chawes and Vinding, {Rebecca K} and Mora-Jensen, {Anna-Rosa C} and Jonathan Thorsen and Sarah N{\o}rgaard and Ebdrup, {Bj{\o}rn H} and Jepsen, {Jens R M} and Birgitte Fagerlund and Klaus B{\o}nnelykke and Lotte Lauritzen and Hans Bisgaard",

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year = "2021",

doi = "10.1111/cdev.13541",

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AU - Sass, Laerke

AU - Bjarnadóttir, Elín

AU - Stokholm, Jakob

AU - Chawes, Bo

AU - Vinding, Rebecca K

AU - Mora-Jensen, Anna-Rosa C

AU - Thorsen, Jonathan

AU - Nørgaard, Sarah

AU - Ebdrup, Bjørn H

AU - Jepsen, Jens R M

AU - Fagerlund, Birgitte

AU - Bønnelykke, Klaus

AU - Lauritzen, Lotte

AU - Bisgaard, Hans

PY - 2021

Y1 - 2021

N2 - A double-blind randomized controlled trial of n-3 long-chain polyunsaturated fatty acid (n-3 LCPUFA) supplementation or matching placebo during third trimester of pregnancy was conducted within the COPSAC2010 mother-child cohort consisting of 736 women and their children. The objective was to determine if maternal n-3 LCPUFA pregnancy supplementation affects offspring neurodevelopment until 6 years. Neurodevelopment was evaluated in 654 children assessing age of motor milestone achievement, language development, cognitive development, general neurodevelopment, and emotional and behavioral problems. Maternal n-3 LCPUFA supplementation during pregnancy improved early language development and reduced the impact of emotional and behavioral problems. The n-3 LCPUFA supplementation was in boys associated with the earlier achievement of gross motor milestones, improved cognitive development, and a reduced impact of emotional and behavioral problems.

AB - A double-blind randomized controlled trial of n-3 long-chain polyunsaturated fatty acid (n-3 LCPUFA) supplementation or matching placebo during third trimester of pregnancy was conducted within the COPSAC2010 mother-child cohort consisting of 736 women and their children. The objective was to determine if maternal n-3 LCPUFA pregnancy supplementation affects offspring neurodevelopment until 6 years. Neurodevelopment was evaluated in 654 children assessing age of motor milestone achievement, language development, cognitive development, general neurodevelopment, and emotional and behavioral problems. Maternal n-3 LCPUFA supplementation during pregnancy improved early language development and reduced the impact of emotional and behavioral problems. The n-3 LCPUFA supplementation was in boys associated with the earlier achievement of gross motor milestones, improved cognitive development, and a reduced impact of emotional and behavioral problems.

U2 - 10.1111/cdev.13541

DO - 10.1111/cdev.13541

M3 - Journal article

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SN - 0009-3920

VL - 92

SP - 1624

EP - 1635

JO - Child Development

JF - Child Development

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