TY - JOUR
T1 - Fish protein hydrolysate elevates plasma bile acids and reduces visceral adipose tissue mass in rats
AU - Liaset, Bjørn
AU - Madsen, Lise
AU - Hao, Qin
AU - Criales, Gabriel
AU - Mellgren, Gunnar
AU - Marschall, Hanns-Ulrich
AU - Hallenborg, Philip
AU - Espe, Marit
AU - Frøyland, Livar
AU - Kristiansen, Karsten
N1 - Keywords: Bile acid; Fish protein hydrolysate; Taurine; Adipose tissue; Energy metabolism; Obesity
PY - 2009
Y1 - 2009
N2 - Conjugation of bile acids (BAs) to the amino acids taurine or glycine increases their solubility and promotes liver BA secretion. Supplementing diets with taurine or glycine modulates BA metabolism and enhances fecal BA excretion in rats. However, it is still unclear whether dietary proteins varying in taurine and glycine contents alter BA metabolism, and thereby modulate the recently discovered systemic effects of BAs. Here we show that rats fed a diet containing saithe fish protein hydrolysate (saithe FPH), rich in taurine and glycine, for 26 days had markedly elevated fasting plasma BA levels relative to rats fed soy protein or casein. Concomitantly, the saithe FPH fed rats had reduced liver lipids and fasting plasma TAG levels. Furthermore, visceral adipose tissue mass was reduced and expression of genes involved in fatty acid oxidation and energy expenditure was induced in perirenal/retroperitoneal adipose tissues of rats fed saithe FPH. Our results provide the first evidence that dietary protein sources with different amino acid compositions can modulate the level of plasma bile acids and our data suggest potential novel mechanisms by which dietary protein sources can affect energy metabolism.
AB - Conjugation of bile acids (BAs) to the amino acids taurine or glycine increases their solubility and promotes liver BA secretion. Supplementing diets with taurine or glycine modulates BA metabolism and enhances fecal BA excretion in rats. However, it is still unclear whether dietary proteins varying in taurine and glycine contents alter BA metabolism, and thereby modulate the recently discovered systemic effects of BAs. Here we show that rats fed a diet containing saithe fish protein hydrolysate (saithe FPH), rich in taurine and glycine, for 26 days had markedly elevated fasting plasma BA levels relative to rats fed soy protein or casein. Concomitantly, the saithe FPH fed rats had reduced liver lipids and fasting plasma TAG levels. Furthermore, visceral adipose tissue mass was reduced and expression of genes involved in fatty acid oxidation and energy expenditure was induced in perirenal/retroperitoneal adipose tissues of rats fed saithe FPH. Our results provide the first evidence that dietary protein sources with different amino acid compositions can modulate the level of plasma bile acids and our data suggest potential novel mechanisms by which dietary protein sources can affect energy metabolism.
U2 - 10.1016/j.bbalip.2009.01.016
DO - 10.1016/j.bbalip.2009.01.016
M3 - Journal article
C2 - 19416649
SN - 0304-4165
VL - 1791
SP - 254
EP - 262
JO - BBA General Subjects
JF - BBA General Subjects
IS - 4
ER -