Foetithiophenes C-F, thiophene derivatives from the roots of Ferula foetida

Mahsa Chitsazian-Yazdi, Sara Agnolet, Sybille Lorenz, Bernd Schneider, Zarrin Es'haghi, Jamal Kasaian, Bahman Khameneh, Mehrdad Iranshahi

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20 Citationer (Scopus)

Abstract

CONTEXT: Ferula foetida Regel (Apiaceae) is an Iranian medicinal plant with various biological activities including antispasmodic and anthelmintic.

OBJECTIVE: The sulfur compounds from the roots of F. foetida were isolated and characterized to test their cytotoxic and antimicrobial activities.

MATERIALS AND METHODS: The methanolic extract of the roots of F. foetida was fractionated using silica column chromatography. The components of each fraction were further purified using RP-HPLC. Their structures were elucidated by 1- and 2-D NMR spectroscopy as well as HREIMS. Their cytotoxic and antimicrobial activities were evaluated using Alamar Blue assay and broth microdilution method, respectively.

RESULTS: Four new thiophene derivatives, namely foetithiophenes C-F (3-6), together with four known compounds, foetithiophenes A (1) and B (2), coniferaldehyde, and sinapic aldehyde, were isolated from the roots of F. foetida. Antimicrobial activities were observed in particular against the Gram-positive bacteria. The best antimicrobial activity was observed for compound 6 against B. cereus with a MIC value 50 µg/mL. The tested compounds did not show cytotoxic properties against MCF-7 and K562 cells.

CONCLUSION: Four new thiophene derivatives including foetithiophenes C-F (3-6) were characterized from the roots of F. foetida. Foetithiophene F (6) exhibited the most potent activity against the Gram-positive bacteria B. cereus.

OriginalsprogEngelsk
TidsskriftPharmaceutical Biology
Vol/bind53
Udgave nummer5
Sider (fra-til)710-714
Antal sider5
ISSN1388-0209
DOI
StatusUdgivet - 2015
Udgivet eksterntJa

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