Four weeks of near-normalisation of blood glucose improves the insulin response to glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes

P V Højberg; T Vilsbøll; R Rabøl; F K Knop; M Bache; T Krarup; Jens Juul Holst; S Madsbad

doi:10.1007/s00125-008-1195-5

Four weeks of near-normalisation of blood glucose improves the insulin response to glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes

P V Højberg, T Vilsbøll, R Rabøl, F K Knop, M Bache, T Krarup, Jens Juul Holst, S Madsbad

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

361 Citationer (Scopus)

Abstract

Udgivelsesdato: 2009-Feb

Originalsprog	Engelsk
Tidsskrift	Diabetologia
Vol/bind	52
Udgave nummer	2
Sider (fra-til)	199-207
Antal sider	9
ISSN	0012-186X
DOI	https://doi.org/10.1007/s00125-008-1195-5
Status	Udgivet - 2008

Bibliografisk note

Keywords: Adult; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Fasting; Fructosamine; Gastric Inhibitory Polypeptide; Glucagon-Like Peptide 1; Hemoglobin A, Glycosylated; Humans; Infusions, Intravenous; Insulin; Male; Middle Aged; Reference Values

Adgang til dokumentet

10.1007/s00125-008-1195-5

Citationsformater

Højberg, P. V., Vilsbøll, T., Rabøl, R., Knop, F. K., Bache, M., Krarup, T., Holst, J. J., & Madsbad, S. (2008). Four weeks of near-normalisation of blood glucose improves the insulin response to glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes. Diabetologia, 52(2), 199-207. https://doi.org/10.1007/s00125-008-1195-5

Four weeks of near-normalisation of blood glucose improves the insulin response to glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes. / Højberg, P V; Vilsbøll, T; Rabøl, R; Knop, F K; Bache, M; Krarup, T; Holst, Jens Juul ; Madsbad, S.

I: Diabetologia, Bind 52, Nr. 2, 2008, s. 199-207.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Højberg, PV, Vilsbøll, T, Rabøl, R, Knop, FK, Bache, M, Krarup, T, Holst, JJ & Madsbad, S 2008, 'Four weeks of near-normalisation of blood glucose improves the insulin response to glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes', Diabetologia, bind 52, nr. 2, s. 199-207. https://doi.org/10.1007/s00125-008-1195-5

@article{d89176a0335611df8ed1000ea68e967b,

title = "Four weeks of near-normalisation of blood glucose improves the insulin response to glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes",

abstract = "OBJECTIVE: The incretin effect is attenuated in patients with type 2 diabetes mellitus, partly as a result of impaired beta cell responsiveness to glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). The aim of the present study was to investigate whether 4 weeks of near-normalisation of the blood glucose level could improve insulin responses to GIP and GLP-1 in patients with type 2 diabetes. METHODS: Eight obese patients with type 2 diabetes with poor glycaemic control (HbA(1c) 8.6 +/- 1.3%), were investigated before and after 4 weeks of near-normalisation of blood glucose (mean blood glucose 7.4 +/- 1.2 mmol/l) using insulin treatment. Before and after insulin treatment the participants underwent three hyperglycaemic clamps (15 mmol/l) with infusion of GLP-1, GIP or saline. Insulin responses were evaluated as the incremental area under the plasma C-peptide curve. RESULTS: Before and after near-normalisation of blood glucose, the C-peptide responses did not differ during the early phase of insulin secretion (0-10 min). The late phase C-peptide response (10-120 min) increased during GIP infusion from 33.0 +/- 8.5 to 103.9 +/- 24.2 (nmol/l) x (110 min)(-1) (p < 0.05) and during GLP-1 infusion from 48.7 +/- 11.8 to 126.6 +/- 32.5 (nmol/l) x (110 min)(-1) (p < 0.05), whereas during saline infusion the late-phase response did not differ before vs after near-normalisation of blood glucose (40.2 +/- 11.2 vs 46.5 +/- 12.7 [nmol/l] x [110 min](-1)). CONCLUSIONS: Near-normalisation of blood glucose for 4 weeks improves beta cell responsiveness to both GLP-1 and GIP by a factor of three to four. No effect was found on beta cell responsiveness to glucose alone. CLINICALTRIALS.GOV ID NO.: NCT 00612950. FUNDING: This study was supported by The Novo Nordisk Foundation, The Medical Science Research Foundation for Copenhagen.",

author = "H{\o}jberg, {P V} and T Vilsb{\o}ll and R Rab{\o}l and Knop, {F K} and M Bache and T Krarup and Holst, {Jens Juul} and S Madsbad",

note = "Keywords: Adult; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Fasting; Fructosamine; Gastric Inhibitory Polypeptide; Glucagon-Like Peptide 1; Hemoglobin A, Glycosylated; Humans; Infusions, Intravenous; Insulin; Male; Middle Aged; Reference Values",

year = "2008",

doi = "10.1007/s00125-008-1195-5",

language = "English",

volume = "52",

pages = "199--207",

journal = "Diabetologia",

issn = "0012-186X",

publisher = "Springer",

number = "2",

}

TY - JOUR

T1 - Four weeks of near-normalisation of blood glucose improves the insulin response to glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes

AU - Højberg, P V

AU - Vilsbøll, T

AU - Rabøl, R

AU - Knop, F K

AU - Bache, M

AU - Krarup, T

AU - Holst, Jens Juul

AU - Madsbad, S

N1 - Keywords: Adult; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Fasting; Fructosamine; Gastric Inhibitory Polypeptide; Glucagon-Like Peptide 1; Hemoglobin A, Glycosylated; Humans; Infusions, Intravenous; Insulin; Male; Middle Aged; Reference Values

PY - 2008

Y1 - 2008

N2 - OBJECTIVE: The incretin effect is attenuated in patients with type 2 diabetes mellitus, partly as a result of impaired beta cell responsiveness to glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). The aim of the present study was to investigate whether 4 weeks of near-normalisation of the blood glucose level could improve insulin responses to GIP and GLP-1 in patients with type 2 diabetes. METHODS: Eight obese patients with type 2 diabetes with poor glycaemic control (HbA(1c) 8.6 +/- 1.3%), were investigated before and after 4 weeks of near-normalisation of blood glucose (mean blood glucose 7.4 +/- 1.2 mmol/l) using insulin treatment. Before and after insulin treatment the participants underwent three hyperglycaemic clamps (15 mmol/l) with infusion of GLP-1, GIP or saline. Insulin responses were evaluated as the incremental area under the plasma C-peptide curve. RESULTS: Before and after near-normalisation of blood glucose, the C-peptide responses did not differ during the early phase of insulin secretion (0-10 min). The late phase C-peptide response (10-120 min) increased during GIP infusion from 33.0 +/- 8.5 to 103.9 +/- 24.2 (nmol/l) x (110 min)(-1) (p < 0.05) and during GLP-1 infusion from 48.7 +/- 11.8 to 126.6 +/- 32.5 (nmol/l) x (110 min)(-1) (p < 0.05), whereas during saline infusion the late-phase response did not differ before vs after near-normalisation of blood glucose (40.2 +/- 11.2 vs 46.5 +/- 12.7 [nmol/l] x [110 min](-1)). CONCLUSIONS: Near-normalisation of blood glucose for 4 weeks improves beta cell responsiveness to both GLP-1 and GIP by a factor of three to four. No effect was found on beta cell responsiveness to glucose alone. CLINICALTRIALS.GOV ID NO.: NCT 00612950. FUNDING: This study was supported by The Novo Nordisk Foundation, The Medical Science Research Foundation for Copenhagen.

AB - OBJECTIVE: The incretin effect is attenuated in patients with type 2 diabetes mellitus, partly as a result of impaired beta cell responsiveness to glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). The aim of the present study was to investigate whether 4 weeks of near-normalisation of the blood glucose level could improve insulin responses to GIP and GLP-1 in patients with type 2 diabetes. METHODS: Eight obese patients with type 2 diabetes with poor glycaemic control (HbA(1c) 8.6 +/- 1.3%), were investigated before and after 4 weeks of near-normalisation of blood glucose (mean blood glucose 7.4 +/- 1.2 mmol/l) using insulin treatment. Before and after insulin treatment the participants underwent three hyperglycaemic clamps (15 mmol/l) with infusion of GLP-1, GIP or saline. Insulin responses were evaluated as the incremental area under the plasma C-peptide curve. RESULTS: Before and after near-normalisation of blood glucose, the C-peptide responses did not differ during the early phase of insulin secretion (0-10 min). The late phase C-peptide response (10-120 min) increased during GIP infusion from 33.0 +/- 8.5 to 103.9 +/- 24.2 (nmol/l) x (110 min)(-1) (p < 0.05) and during GLP-1 infusion from 48.7 +/- 11.8 to 126.6 +/- 32.5 (nmol/l) x (110 min)(-1) (p < 0.05), whereas during saline infusion the late-phase response did not differ before vs after near-normalisation of blood glucose (40.2 +/- 11.2 vs 46.5 +/- 12.7 [nmol/l] x [110 min](-1)). CONCLUSIONS: Near-normalisation of blood glucose for 4 weeks improves beta cell responsiveness to both GLP-1 and GIP by a factor of three to four. No effect was found on beta cell responsiveness to glucose alone. CLINICALTRIALS.GOV ID NO.: NCT 00612950. FUNDING: This study was supported by The Novo Nordisk Foundation, The Medical Science Research Foundation for Copenhagen.

U2 - 10.1007/s00125-008-1195-5

DO - 10.1007/s00125-008-1195-5

M3 - Journal article

C2 - 19037628

VL - 52

SP - 199

EP - 207

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 2

ER -