From plant scent defense to biopesticide discovery: Evaluation of toxicity and acetylcholinesterase docking properties for Lamiaceae monoterpenes

Jose Guedes de Sena Filho*, Anderson Soares de Almeida, Delia Pinto-Zevallos, Ighor Costa Barreto, Sócrates Cabral de Holanda Cavalcanti, Rogeria Nunes, Adenir Vieira Teodoro, Haroudo Sátiro Xavier, José Maria Barbosa Filho, Leluo Guan, Andre L.A. Neves, Jennifer M. Duringer

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskriftReviewForskningpeer review

14 Citationer (Scopus)

Abstract

Monoterpenes are a highly diverse group of chemical scents that originate from plant secondary metabolic processes, one purpose of which is to serve as a defense against herbivores. Plant-derived monoterpenes produced from Lamiaceae species have demonstrated acaricidal activity against pest mites and ticks. However, the mechanism by which these compounds carry out the demise of this group of arachnids is poorly understood. Here, we review the chemistry and bioactivity of these promising compounds and subsequently assess their potential toxicity to mites and ticks through measurement of their docking ability to amino acid residues of the binding pocket of Drosophila melanogaster acetylcholinesterase (AChE). We identified 27 monoterpenes of the Lamiaceae family from the literature that were effective against mite (Varroidae, Tetranychidae, Eriophyidae) and tick (Ixodidae) species that are problematic in agricultural production. Screening of these compounds showed that monoterpenoids possessing methyl groups, such as carvacrol, linalool, α-terpineol, bornyl acetate, and terpine-4-ol, strongly bind to D. melanogaster AChE. Linalool, which fits into the binding pocket in the amino acid catalytic triad of AChE (oxyanion hole residues, hydrogen bond interaction with GLU 237, and anionic binding with TRP 83), was identified as the most promising target for further optimization studies. We propose that monoterpenes which interact strongly with amino acid residues of the AChE receptor be targeted for development of effective, naturally produced biocontrol pesticides, as this model demonstrates potential for discovery of new acaricide compounds in a high throughput manner.

OriginalsprogEngelsk
Artikelnummer106126
TidsskriftCrop Protection
Vol/bind164
ISSN0261-2194
DOI
StatusUdgivet - 2023

Bibliografisk note

Funding Information:
The authors would like to thank the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) for financial support.

Publisher Copyright:
© 2022 Elsevier Ltd

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