Functional and molecular characterization of prostaglandin E2 dilatory receptors in the rat craniovascular system in relevance to migraine

Maja Myren; Michael Baun; Kenneth Beri Ploug; Inger Jansen-Olesen; Jes Olesen; Saurabh Gupta

doi:10.1177/0333102409357957

Functional and molecular characterization of prostaglandin E2 dilatory receptors in the rat craniovascular system in relevance to migraine

Maja Myren, Michael Baun, Kenneth Beri Ploug, Inger Jansen-Olesen, Jes Olesen, Saurabh Gupta

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

17 Citationer (Scopus)

Abstract

Migraine pain is thought to involve an increase in trigeminal nerve terminal activity around large cerebral and meningeal arteries, leading to vasodilatation. Because prostaglandin E(2) (PGE(2)) is elevated in cephalic venous blood during migraine attacks, and is also capable of inducing headache in healthy volunteers, we hypothesize that PGE(2) dilatory receptors, EP(2) and EP(4), mediate the response.

Originalsprog	Engelsk
Tidsskrift	Cephalalgia
Vol/bind	30
Udgave nummer	9
Sider (fra-til)	1110-22
Antal sider	13
ISSN	0333-1024
DOI	https://doi.org/10.1177/0333102409357957
Status	Udgivet - 1 sep. 2010

Adgang til dokumentet

10.1177/0333102409357957

Citationsformater

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abstract = "Migraine pain is thought to involve an increase in trigeminal nerve terminal activity around large cerebral and meningeal arteries, leading to vasodilatation. Because prostaglandin E(2) (PGE(2)) is elevated in cephalic venous blood during migraine attacks, and is also capable of inducing headache in healthy volunteers, we hypothesize that PGE(2) dilatory receptors, EP(2) and EP(4), mediate the response.",

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T1 - Functional and molecular characterization of prostaglandin E2 dilatory receptors in the rat craniovascular system in relevance to migraine

AU - Myren, Maja

AU - Baun, Michael

AU - Ploug, Kenneth Beri

AU - Jansen-Olesen, Inger

AU - Olesen, Jes

AU - Gupta, Saurabh

PY - 2010/9/1

Y1 - 2010/9/1

N2 - Migraine pain is thought to involve an increase in trigeminal nerve terminal activity around large cerebral and meningeal arteries, leading to vasodilatation. Because prostaglandin E(2) (PGE(2)) is elevated in cephalic venous blood during migraine attacks, and is also capable of inducing headache in healthy volunteers, we hypothesize that PGE(2) dilatory receptors, EP(2) and EP(4), mediate the response.

AB - Migraine pain is thought to involve an increase in trigeminal nerve terminal activity around large cerebral and meningeal arteries, leading to vasodilatation. Because prostaglandin E(2) (PGE(2)) is elevated in cephalic venous blood during migraine attacks, and is also capable of inducing headache in healthy volunteers, we hypothesize that PGE(2) dilatory receptors, EP(2) and EP(4), mediate the response.

U2 - 10.1177/0333102409357957

DO - 10.1177/0333102409357957

M3 - Journal article

SN - 0333-1024

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EP - 1122

JO - Cephalalgia

JF - Cephalalgia

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