Functionalized Food-Grade Biopolymer-Nanosilica Based Hybrid Hydrogels as Sustained Delivery Devices of Rutin

Hriday Bera; Yasir Faraz Abbasi; Ang Kah Hoong; Low Phoe Be; Tay Juan Wuan; Haifei Guo; Dongmei Cun; Mingshi Yang; Leong Yock Seen; Lim Lip Woan; Sia Qing Ying

doi:10.1007/s10924-020-01876-8

Functionalized Food-Grade Biopolymer-Nanosilica Based Hybrid Hydrogels as Sustained Delivery Devices of Rutin

Hriday Bera^*, Yasir Faraz Abbasi, Ang Kah Hoong, Low Phoe Be, Tay Juan Wuan, Haifei Guo, Dongmei Cun, Mingshi Yang, Leong Yock Seen, Lim Lip Woan, Sia Qing Ying

^*Corresponding author af dette arbejde

Lægemidler, processer og produkter

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

3 Citationer (Scopus)

14 Downloads (Pure)

Abstract

Novel tamarind gum (TG) or carboxymethyl tamarind gum (CMTG) blended diethanolamine-functionalized pectin (DFP) based hydrogels reinforced with calcium silicate (CS) were developed for sustained delivery of rutin (RUT). The DFP (D_A, 48.7%) and CMTG (DS, 50.0%) were initially synthesized and analyzed through ¹H-NMR, FTIR, XRD and DSC studies. RUT-loaded hybrid hydrogels were subsequently afforded by Ca²⁺-induced gelation protocol. The hydrogels portrayed acceptable RUT entrapping efficiency (DEE, 29–43%), delayed eluting behaviour (Q_6h, 65–100%) and variable swelling at 6 h (16–172%), which were significantly influenced by formulation variables. The RUT dissolution profile of the optimized hydrogels (F-5) obeyed Korsmeyer–Peppas kinetic model with anomalous transport driven mechanism. These matrices also demonstrated excellent mucoadhesion property and biodegradability. Furthermore, the hydrogels revealed their smooth but distorted surface morphology and drug-carrier compatibility with attenuated RUT crystallinity. These hydrogels matrices were thus evidenced to be appropriate for the delivery of hydrophobic RUT in its solubilised form.

Originalsprog	Engelsk
Tidsskrift	Journal of Polymers and the Environment
Vol/bind	29
Sider (fra-til)	260-270
ISSN	1566-2543
DOI	https://doi.org/10.1007/s10924-020-01876-8
Status	Udgivet - 2021

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10.1007/s10924-020-01876-8

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@article{3ae3641f66bf4112b24bb20d94cd7231,

title = "Functionalized Food-Grade Biopolymer-Nanosilica Based Hybrid Hydrogels as Sustained Delivery Devices of Rutin",

abstract = "Novel tamarind gum (TG) or carboxymethyl tamarind gum (CMTG) blended diethanolamine-functionalized pectin (DFP) based hydrogels reinforced with calcium silicate (CS) were developed for sustained delivery of rutin (RUT). The DFP (DA, 48.7%) and CMTG (DS, 50.0%) were initially synthesized and analyzed through 1H-NMR, FTIR, XRD and DSC studies. RUT-loaded hybrid hydrogels were subsequently afforded by Ca2+-induced gelation protocol. The hydrogels portrayed acceptable RUT entrapping efficiency (DEE, 29–43%), delayed eluting behaviour (Q6h, 65–100%) and variable swelling at 6 h (16–172%), which were significantly influenced by formulation variables. The RUT dissolution profile of the optimized hydrogels (F-5) obeyed Korsmeyer–Peppas kinetic model with anomalous transport driven mechanism. These matrices also demonstrated excellent mucoadhesion property and biodegradability. Furthermore, the hydrogels revealed their smooth but distorted surface morphology and drug-carrier compatibility with attenuated RUT crystallinity. These hydrogels matrices were thus evidenced to be appropriate for the delivery of hydrophobic RUT in its solubilised form.",

keywords = "Biopolymer modification, Calcium silicate, High-methoxyl pectin, Nutraceuticals, Tamarind gum",

author = "Hriday Bera and Abbasi, {Yasir Faraz} and Hoong, {Ang Kah} and Be, {Low Phoe} and Wuan, {Tay Juan} and Haifei Guo and Dongmei Cun and Mingshi Yang and Seen, {Leong Yock} and Woan, {Lim Lip} and Ying, {Sia Qing}",

year = "2021",

doi = "10.1007/s10924-020-01876-8",

language = "English",

volume = "29",

pages = "260--270",

journal = "Journal of Polymers and the Environment",

issn = "1566-2543",

publisher = "Springer New York",

}

TY - JOUR

T1 - Functionalized Food-Grade Biopolymer-Nanosilica Based Hybrid Hydrogels as Sustained Delivery Devices of Rutin

AU - Bera, Hriday

AU - Abbasi, Yasir Faraz

AU - Hoong, Ang Kah

AU - Be, Low Phoe

AU - Wuan, Tay Juan

AU - Guo, Haifei

AU - Cun, Dongmei

AU - Yang, Mingshi

AU - Seen, Leong Yock

AU - Woan, Lim Lip

AU - Ying, Sia Qing

PY - 2021

Y1 - 2021

N2 - Novel tamarind gum (TG) or carboxymethyl tamarind gum (CMTG) blended diethanolamine-functionalized pectin (DFP) based hydrogels reinforced with calcium silicate (CS) were developed for sustained delivery of rutin (RUT). The DFP (DA, 48.7%) and CMTG (DS, 50.0%) were initially synthesized and analyzed through 1H-NMR, FTIR, XRD and DSC studies. RUT-loaded hybrid hydrogels were subsequently afforded by Ca2+-induced gelation protocol. The hydrogels portrayed acceptable RUT entrapping efficiency (DEE, 29–43%), delayed eluting behaviour (Q6h, 65–100%) and variable swelling at 6 h (16–172%), which were significantly influenced by formulation variables. The RUT dissolution profile of the optimized hydrogels (F-5) obeyed Korsmeyer–Peppas kinetic model with anomalous transport driven mechanism. These matrices also demonstrated excellent mucoadhesion property and biodegradability. Furthermore, the hydrogels revealed their smooth but distorted surface morphology and drug-carrier compatibility with attenuated RUT crystallinity. These hydrogels matrices were thus evidenced to be appropriate for the delivery of hydrophobic RUT in its solubilised form.

AB - Novel tamarind gum (TG) or carboxymethyl tamarind gum (CMTG) blended diethanolamine-functionalized pectin (DFP) based hydrogels reinforced with calcium silicate (CS) were developed for sustained delivery of rutin (RUT). The DFP (DA, 48.7%) and CMTG (DS, 50.0%) were initially synthesized and analyzed through 1H-NMR, FTIR, XRD and DSC studies. RUT-loaded hybrid hydrogels were subsequently afforded by Ca2+-induced gelation protocol. The hydrogels portrayed acceptable RUT entrapping efficiency (DEE, 29–43%), delayed eluting behaviour (Q6h, 65–100%) and variable swelling at 6 h (16–172%), which were significantly influenced by formulation variables. The RUT dissolution profile of the optimized hydrogels (F-5) obeyed Korsmeyer–Peppas kinetic model with anomalous transport driven mechanism. These matrices also demonstrated excellent mucoadhesion property and biodegradability. Furthermore, the hydrogels revealed their smooth but distorted surface morphology and drug-carrier compatibility with attenuated RUT crystallinity. These hydrogels matrices were thus evidenced to be appropriate for the delivery of hydrophobic RUT in its solubilised form.

KW - Biopolymer modification

KW - Calcium silicate

KW - High-methoxyl pectin

KW - Nutraceuticals

KW - Tamarind gum

U2 - 10.1007/s10924-020-01876-8

DO - 10.1007/s10924-020-01876-8

M3 - Journal article

AN - SCOPUS:85090944850

SN - 1566-2543

VL - 29

SP - 260

EP - 270

JO - Journal of Polymers and the Environment

JF - Journal of Polymers and the Environment

ER -