Functions of TopBP1 in preserving genome integrity during mitosis

Jonas Bagge; Vibe H. Oestergaard; Michael Lisby

doi:10.1016/j.semcdb.2020.08.009

Functions of TopBP1 in preserving genome integrity during mitosis

Jonas Bagge, Vibe H. Oestergaard, Michael Lisby^*

^*Corresponding author af dette arbejde

Functional genomics

Publikation: Bidrag til tidsskrift › Review › Forskning › peer review

1 Citationer (Scopus)

Abstract

TopBP1/Rad4/Dpb11 is an essential eukaryotic protein with important roles in DNA replication, DNA repair, DNA damage checkpoint activation, and chromosome segregation. TopBP1 serves as a scaffold to assemble protein complexes in a phosphorylation-dependent manner via its multiple BRCT-repeats. Recently, it has become clear that TopBP1 is repurposed to scaffold different processes dependent on cell cycle regulated changes in phosphorylation of client proteins. Here we review the functions of human TopBP1 in maintaining genome integrity during mitosis.

Originalsprog	Engelsk
Tidsskrift	Seminars in Cell and Developmental Biology
Vol/bind	113
Sider (fra-til)	57-64
Antal sider	8
ISSN	1084-9521
DOI	https://doi.org/10.1016/j.semcdb.2020.08.009
Status	Udgivet - 2021

Adgang til dokumentet

10.1016/j.semcdb.2020.08.009

Citationsformater

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title = "Functions of TopBP1 in preserving genome integrity during mitosis",

abstract = "TopBP1/Rad4/Dpb11 is an essential eukaryotic protein with important roles in DNA replication, DNA repair, DNA damage checkpoint activation, and chromosome segregation. TopBP1 serves as a scaffold to assemble protein complexes in a phosphorylation-dependent manner via its multiple BRCT-repeats. Recently, it has become clear that TopBP1 is repurposed to scaffold different processes dependent on cell cycle regulated changes in phosphorylation of client proteins. Here we review the functions of human TopBP1 in maintaining genome integrity during mitosis.",

keywords = "Anaphase Bridges, Homologous recombination, MDC1, MiDAS, Mitosis, SLX4, TopBP1",

author = "Jonas Bagge and Oestergaard, {Vibe H.} and Michael Lisby",

year = "2021",

doi = "10.1016/j.semcdb.2020.08.009",

language = "English",

volume = "113",

pages = "57--64",

journal = "Seminars in Cell and Developmental Biology",

issn = "1084-9521",

publisher = "Academic Press",

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TY - JOUR

T1 - Functions of TopBP1 in preserving genome integrity during mitosis

AU - Bagge, Jonas

AU - Oestergaard, Vibe H.

AU - Lisby, Michael

PY - 2021

Y1 - 2021

N2 - TopBP1/Rad4/Dpb11 is an essential eukaryotic protein with important roles in DNA replication, DNA repair, DNA damage checkpoint activation, and chromosome segregation. TopBP1 serves as a scaffold to assemble protein complexes in a phosphorylation-dependent manner via its multiple BRCT-repeats. Recently, it has become clear that TopBP1 is repurposed to scaffold different processes dependent on cell cycle regulated changes in phosphorylation of client proteins. Here we review the functions of human TopBP1 in maintaining genome integrity during mitosis.

AB - TopBP1/Rad4/Dpb11 is an essential eukaryotic protein with important roles in DNA replication, DNA repair, DNA damage checkpoint activation, and chromosome segregation. TopBP1 serves as a scaffold to assemble protein complexes in a phosphorylation-dependent manner via its multiple BRCT-repeats. Recently, it has become clear that TopBP1 is repurposed to scaffold different processes dependent on cell cycle regulated changes in phosphorylation of client proteins. Here we review the functions of human TopBP1 in maintaining genome integrity during mitosis.

KW - Anaphase Bridges

KW - Homologous recombination

KW - MDC1

KW - MiDAS

KW - Mitosis

KW - SLX4

KW - TopBP1

U2 - 10.1016/j.semcdb.2020.08.009

DO - 10.1016/j.semcdb.2020.08.009

M3 - Review

C2 - 32912640

AN - SCOPUS:85090490073

VL - 113

SP - 57

EP - 64

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

SN - 1084-9521

ER -