Fungal infection as a risk factor for HIV disease progression among patients with a CD4 count above 200/microl in the era of cART

Daria Podlekareva; Amanda Mocroft; Ole Kirk; Peter Reiss; Pauls Aldins; Christine Katlama; Helen Kovari; Hans-Juergen Stellbrink; Antonella D'Arminio Monforte; Jens D Lundgren; NN NN

doi:10.1080/00365540802227094

Fungal infection as a risk factor for HIV disease progression among patients with a CD4 count above 200/microl in the era of cART

Daria Podlekareva, Amanda Mocroft, Ole Kirk, Peter Reiss, Pauls Aldins, Christine Katlama, Helen Kovari, Hans-Juergen Stellbrink, Antonella D'Arminio Monforte, Jens D Lundgren, NN NN

Institut for Klinisk Medicin

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

2 Citationer (Scopus)

Abstract

Udgivelsesdato: 2008-null

Originalsprog	Engelsk
Tidsskrift	Scandinavian Journal of Infectious Diseases
Vol/bind	40
Udgave nummer	11-12
Sider (fra-til)	908-13
Antal sider	5
ISSN	0036-5548
DOI	https://doi.org/10.1080/00365540802227094 https://doi.org/10.1080/00365540802227094
Status	Udgivet - 2008

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Citationsformater

Podlekareva, D., Mocroft, A., Kirk, O., Reiss, P., Aldins, P., Katlama, C., Kovari, H., Stellbrink, H-J., D'Arminio Monforte, A., Lundgren, J. D., & NN, NN. (2008). Fungal infection as a risk factor for HIV disease progression among patients with a CD4 count above 200/microl in the era of cART. Scandinavian Journal of Infectious Diseases, 40(11-12), 908-13. https://doi.org/10.1080/00365540802227094, https://doi.org/10.1080/00365540802227094

Fungal infection as a risk factor for HIV disease progression among patients with a CD4 count above 200/microl in the era of cART. / Podlekareva, Daria; Mocroft, Amanda; Kirk, Ole; Reiss, Peter; Aldins, Pauls; Katlama, Christine; Kovari, Helen; Stellbrink, Hans-Juergen; D'Arminio Monforte, Antonella; Lundgren, Jens D; NN, NN.

I: Scandinavian Journal of Infectious Diseases, Bind 40, Nr. 11-12, 2008, s. 908-13.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Podlekareva, D, Mocroft, A, Kirk, O, Reiss, P, Aldins, P, Katlama, C, Kovari, H, Stellbrink, H-J, D'Arminio Monforte, A, Lundgren, JD & NN, NN 2008, 'Fungal infection as a risk factor for HIV disease progression among patients with a CD4 count above 200/microl in the era of cART', Scandinavian Journal of Infectious Diseases, bind 40, nr. 11-12, s. 908-13. https://doi.org/10.1080/00365540802227094, https://doi.org/10.1080/00365540802227094

Podlekareva, Daria ; Mocroft, Amanda ; Kirk, Ole ; Reiss, Peter ; Aldins, Pauls ; Katlama, Christine ; Kovari, Helen ; Stellbrink, Hans-Juergen ; D'Arminio Monforte, Antonella ; Lundgren, Jens D ; NN, NN. / Fungal infection as a risk factor for HIV disease progression among patients with a CD4 count above 200/microl in the era of cART. I: Scandinavian Journal of Infectious Diseases. 2008 ; Bind 40, Nr. 11-12. s. 908-13.

@article{56add2c0c50a11dd8ca2000ea68e967b,

title = "Fungal infection as a risk factor for HIV disease progression among patients with a CD4 count above 200/microl in the era of cART",

abstract = "The identification of clinical risk factors for AIDS in patients with preserved immune function is of significant interest. We examined whether patients with fungal infection (FI) and CD4 cell count >/=200/microl were at higher risk of disease progression in the era of cART. 11,009 EuroSIDA patients were followed from their first CD4 cell count >/=200/microl after 1 January 1997 until progression to any non-azoles/amphotericin B susceptible (AAS) AIDS disease, last visit or death. Initiation of antimycotic therapy (AMT) was used as a marker of FI and was modelled as a time-updated covariate using Poisson regression. After adjustment for current CD4 cell count, HIV-RNA, starting cART and diagnosis of AAS-AIDS, AMT was significantly associated with an increased incidence of non-AAS-AIDS (IRR=1.55, 95% CI 1.17-2.06, p=0.0024). Despite low incidence of AIDS in the cART era, FI in patients with a CD4 cell count >/=200/microl is associated with a 55% higher risk of non-AAS-AIDS (95% confidence interval 1.17-2.06, p=0.0024). These data suggest that patients with FI are more immune compromized than would be expected from their CD4 cell count alone. FI can be used as a clinical marker for disease progression and indirect indicator for initiation/changing cART in settings where laboratory facilities are limited.",

author = "Daria Podlekareva and Amanda Mocroft and Ole Kirk and Peter Reiss and Pauls Aldins and Christine Katlama and Helen Kovari and Hans-Juergen Stellbrink and {D'Arminio Monforte}, Antonella and Lundgren, {Jens D} and NN NN",

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doi = "10.1080/00365540802227094",

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T1 - Fungal infection as a risk factor for HIV disease progression among patients with a CD4 count above 200/microl in the era of cART

AU - Podlekareva, Daria

AU - Mocroft, Amanda

AU - Kirk, Ole

AU - Reiss, Peter

AU - Aldins, Pauls

AU - Katlama, Christine

AU - Kovari, Helen

AU - Stellbrink, Hans-Juergen

AU - D'Arminio Monforte, Antonella

AU - Lundgren, Jens D

AU - NN, NN

PY - 2008

Y1 - 2008

N2 - The identification of clinical risk factors for AIDS in patients with preserved immune function is of significant interest. We examined whether patients with fungal infection (FI) and CD4 cell count >/=200/microl were at higher risk of disease progression in the era of cART. 11,009 EuroSIDA patients were followed from their first CD4 cell count >/=200/microl after 1 January 1997 until progression to any non-azoles/amphotericin B susceptible (AAS) AIDS disease, last visit or death. Initiation of antimycotic therapy (AMT) was used as a marker of FI and was modelled as a time-updated covariate using Poisson regression. After adjustment for current CD4 cell count, HIV-RNA, starting cART and diagnosis of AAS-AIDS, AMT was significantly associated with an increased incidence of non-AAS-AIDS (IRR=1.55, 95% CI 1.17-2.06, p=0.0024). Despite low incidence of AIDS in the cART era, FI in patients with a CD4 cell count >/=200/microl is associated with a 55% higher risk of non-AAS-AIDS (95% confidence interval 1.17-2.06, p=0.0024). These data suggest that patients with FI are more immune compromized than would be expected from their CD4 cell count alone. FI can be used as a clinical marker for disease progression and indirect indicator for initiation/changing cART in settings where laboratory facilities are limited.

AB - The identification of clinical risk factors for AIDS in patients with preserved immune function is of significant interest. We examined whether patients with fungal infection (FI) and CD4 cell count >/=200/microl were at higher risk of disease progression in the era of cART. 11,009 EuroSIDA patients were followed from their first CD4 cell count >/=200/microl after 1 January 1997 until progression to any non-azoles/amphotericin B susceptible (AAS) AIDS disease, last visit or death. Initiation of antimycotic therapy (AMT) was used as a marker of FI and was modelled as a time-updated covariate using Poisson regression. After adjustment for current CD4 cell count, HIV-RNA, starting cART and diagnosis of AAS-AIDS, AMT was significantly associated with an increased incidence of non-AAS-AIDS (IRR=1.55, 95% CI 1.17-2.06, p=0.0024). Despite low incidence of AIDS in the cART era, FI in patients with a CD4 cell count >/=200/microl is associated with a 55% higher risk of non-AAS-AIDS (95% confidence interval 1.17-2.06, p=0.0024). These data suggest that patients with FI are more immune compromized than would be expected from their CD4 cell count alone. FI can be used as a clinical marker for disease progression and indirect indicator for initiation/changing cART in settings where laboratory facilities are limited.

U2 - 10.1080/00365540802227094

DO - 10.1080/00365540802227094

M3 - Journal article

C2 - 18609197

VL - 40

SP - 908

EP - 913

JO - Infectious Diseases

JF - Infectious Diseases

SN - 2374-4235

IS - 11-12

ER -