Galectin-8 in IgA nephritis: decreased binding of IgA by galectin-8 affinity chromatography and associated increased binding in non-IgA serum glycoproteins

Carl Michael Carlsson, Omran Bakoush, Lotta Tengroth, Ola Kilsgård, Johan Malmström, Thomas Hellmark, Mårten Segelmark, Hakon Leffler

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

6 Citationer (Scopus)

Abstract

Immunoglobulin A nephritis (IgAN) is the most common primary glomerulonephritis worldwide. It is caused by accumulation of IgA1-containing immune complexes in the kidney resulting in renal failure, which is thought to be due to altered glycosylation of IgA with a decrease of 2-3-sialylated galactosides (NeuAcα2-3Gal).
OriginalsprogEngelsk
TidsskriftJournal of Clinical Immunology
Vol/bind32
Udgave nummer2
Sider (fra-til)246-55
Antal sider10
ISSN0271-9142
DOI
StatusUdgivet - apr. 2012
Udgivet eksterntJa

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