GDF15 is still a mystery hormone

Casper M. Sigvardsen; Michael M. Richter; Sarah Engelbeen; Maximilian Kleinert; Erik A. Richter

doi:10.1016/j.tem.2024.09.002

GDF15 is still a mystery hormone

Casper M. Sigvardsen, Michael M. Richter, Sarah Engelbeen, Maximilian Kleinert^*, Erik A. Richter^*

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Review › Forskning › peer review

Abstract

Growth differentiation factor 15 (GDF15) is a member of the transforming growth factor-β (TGF-β) superfamily. Despite its identification over 20 years ago, the functions of GDF15 remain complex and not fully elucidated. Its concentration in plasma varies widely depending on the physiological and pathophysiological state of the organism. GDF15 has been described to regulate food intake and insulin sensitivity in rodents via the GDNF family receptor α-like (GFRAL) receptor, and to be elevated in pregnancy and many disease states and decreased in physically fit individuals. We discuss the latest developments in the regulation of GDF15 secretion and its diverse physiological effects, and touch upon possible GFRAL-independent effects of GDF15. In addition, we discuss the effects of proteins and peptides derived from the same precursor protein as GDF15.

Originalsprog	Engelsk
Tidsskrift	Trends in Endocrinology and Metabolism
ISSN	1043-2760
DOI	https://doi.org/10.1016/j.tem.2024.09.002
Status	Accepteret/In press - 2024

Bibliografisk note

Publisher Copyright:
© 2024 Elsevier Ltd

Adgang til dokumentet

10.1016/j.tem.2024.09.002

Citationsformater

@article{4b065e352d7f45189fcf14e473883abd,

title = "GDF15 is still a mystery hormone",

abstract = "Growth differentiation factor 15 (GDF15) is a member of the transforming growth factor-β (TGF-β) superfamily. Despite its identification over 20 years ago, the functions of GDF15 remain complex and not fully elucidated. Its concentration in plasma varies widely depending on the physiological and pathophysiological state of the organism. GDF15 has been described to regulate food intake and insulin sensitivity in rodents via the GDNF family receptor α-like (GFRAL) receptor, and to be elevated in pregnancy and many disease states and decreased in physically fit individuals. We discuss the latest developments in the regulation of GDF15 secretion and its diverse physiological effects, and touch upon possible GFRAL-independent effects of GDF15. In addition, we discuss the effects of proteins and peptides derived from the same precursor protein as GDF15.",

keywords = "appetite, energy expenditure, insulin sensitivity, weight loss",

author = "Sigvardsen, {Casper M.} and Richter, {Michael M.} and Sarah Engelbeen and Maximilian Kleinert and Richter, {Erik A.}",

note = "Publisher Copyright: {\textcopyright} 2024 Elsevier Ltd",

year = "2024",

doi = "10.1016/j.tem.2024.09.002",

language = "English",

journal = "Trends in Endocrinology and Metabolism",

issn = "1043-2760",

publisher = "Elsevier Ltd. * Trends Journals",

}

TY - JOUR

T1 - GDF15 is still a mystery hormone

AU - Sigvardsen, Casper M.

AU - Richter, Michael M.

AU - Engelbeen, Sarah

AU - Kleinert, Maximilian

AU - Richter, Erik A.

PY - 2024

Y1 - 2024

N2 - Growth differentiation factor 15 (GDF15) is a member of the transforming growth factor-β (TGF-β) superfamily. Despite its identification over 20 years ago, the functions of GDF15 remain complex and not fully elucidated. Its concentration in plasma varies widely depending on the physiological and pathophysiological state of the organism. GDF15 has been described to regulate food intake and insulin sensitivity in rodents via the GDNF family receptor α-like (GFRAL) receptor, and to be elevated in pregnancy and many disease states and decreased in physically fit individuals. We discuss the latest developments in the regulation of GDF15 secretion and its diverse physiological effects, and touch upon possible GFRAL-independent effects of GDF15. In addition, we discuss the effects of proteins and peptides derived from the same precursor protein as GDF15.

AB - Growth differentiation factor 15 (GDF15) is a member of the transforming growth factor-β (TGF-β) superfamily. Despite its identification over 20 years ago, the functions of GDF15 remain complex and not fully elucidated. Its concentration in plasma varies widely depending on the physiological and pathophysiological state of the organism. GDF15 has been described to regulate food intake and insulin sensitivity in rodents via the GDNF family receptor α-like (GFRAL) receptor, and to be elevated in pregnancy and many disease states and decreased in physically fit individuals. We discuss the latest developments in the regulation of GDF15 secretion and its diverse physiological effects, and touch upon possible GFRAL-independent effects of GDF15. In addition, we discuss the effects of proteins and peptides derived from the same precursor protein as GDF15.

KW - appetite

KW - energy expenditure

KW - insulin sensitivity

KW - weight loss

U2 - 10.1016/j.tem.2024.09.002

DO - 10.1016/j.tem.2024.09.002

M3 - Review

AN - SCOPUS:85207765957

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

SN - 1043-2760

ER -