Generalized decrease in brain glucose metabolism during fasting in humans studied by PET.

C Redies; L J Hoffer; C Beil; E B Marliss; A C Evans; F Lariviere; S Marrett; E Meyer; M Diksic; A Gjedde

Generalized decrease in brain glucose metabolism during fasting in humans studied by PET.

C Redies, L J Hoffer, C Beil, E B Marliss, A C Evans, F Lariviere, S Marrett, E Meyer, M Diksic, A Gjedde

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

41 Citationer (Scopus)

Abstract

Udgivelsesdato: 1989-Jun

Originalsprog	Engelsk
Tidsskrift	American Journal of Physiology (Consolidated)
Vol/bind	256
Udgave nummer	6 Pt 1
Sider (fra-til)	E805-10
ISSN	0002-9513
Status	Udgivet - 1989
Udgivet eksternt	Ja

Citationsformater

@article{431d91b0b31511debc73000ea68e967b,

title = "Generalized decrease in brain glucose metabolism during fasting in humans studied by PET.",

abstract = "In prolonged fasting, the brain derives a large portion of its oxidative energy from the ketone bodies, beta-hydroxybutyrate and acetoacetate, thereby reducing whole body glucose consumption. Energy substrate utilization differs regionally in the brain of fasting rat, but comparable information has hitherto been unavailable in humans. We used positron emission tomography (PET) to study regional brain glucose and oxygen metabolism, blood flow, and blood volume in four obese subjects before and after a 3-wk total fast. Whole brain glucose utilization fell to 54% of control (postabsorptive) values (P less than 0.002). The whole brain rate constant for glucose tracer phosphorylation fell to 51% of control values (P less than 0.002). Both parameters decreased uniformly throughout the brain. The 2-fluoro-2-deoxy-D-glucose lumped constant decreased from a control value of 0.57 to 0.43 (P less than 0.01). Regional blood-brain barrier transfer coefficients for glucose tracer, regional oxygen utilization, blood flow, and blood volume were unchanged.",

author = "C Redies and Hoffer, {L J} and C Beil and Marliss, {E B} and Evans, {A C} and F Lariviere and S Marrett and E Meyer and M Diksic and A Gjedde",

year = "1989",

language = "English",

volume = "256",

pages = "E805--10",

journal = "American Journal of Physiology (Consolidated)",

issn = "0002-9513",

publisher = "American Physiological Society",

number = "6 Pt 1",

}

TY - JOUR

T1 - Generalized decrease in brain glucose metabolism during fasting in humans studied by PET.

AU - Redies, C

AU - Hoffer, L J

AU - Beil, C

AU - Marliss, E B

AU - Evans, A C

AU - Lariviere, F

AU - Marrett, S

AU - Meyer, E

AU - Diksic, M

AU - Gjedde, A

PY - 1989

Y1 - 1989

N2 - In prolonged fasting, the brain derives a large portion of its oxidative energy from the ketone bodies, beta-hydroxybutyrate and acetoacetate, thereby reducing whole body glucose consumption. Energy substrate utilization differs regionally in the brain of fasting rat, but comparable information has hitherto been unavailable in humans. We used positron emission tomography (PET) to study regional brain glucose and oxygen metabolism, blood flow, and blood volume in four obese subjects before and after a 3-wk total fast. Whole brain glucose utilization fell to 54% of control (postabsorptive) values (P less than 0.002). The whole brain rate constant for glucose tracer phosphorylation fell to 51% of control values (P less than 0.002). Both parameters decreased uniformly throughout the brain. The 2-fluoro-2-deoxy-D-glucose lumped constant decreased from a control value of 0.57 to 0.43 (P less than 0.01). Regional blood-brain barrier transfer coefficients for glucose tracer, regional oxygen utilization, blood flow, and blood volume were unchanged.

AB - In prolonged fasting, the brain derives a large portion of its oxidative energy from the ketone bodies, beta-hydroxybutyrate and acetoacetate, thereby reducing whole body glucose consumption. Energy substrate utilization differs regionally in the brain of fasting rat, but comparable information has hitherto been unavailable in humans. We used positron emission tomography (PET) to study regional brain glucose and oxygen metabolism, blood flow, and blood volume in four obese subjects before and after a 3-wk total fast. Whole brain glucose utilization fell to 54% of control (postabsorptive) values (P less than 0.002). The whole brain rate constant for glucose tracer phosphorylation fell to 51% of control values (P less than 0.002). Both parameters decreased uniformly throughout the brain. The 2-fluoro-2-deoxy-D-glucose lumped constant decreased from a control value of 0.57 to 0.43 (P less than 0.01). Regional blood-brain barrier transfer coefficients for glucose tracer, regional oxygen utilization, blood flow, and blood volume were unchanged.

M3 - Journal article

C2 - 2786677

SN - 0002-9513

VL - 256

SP - E805-10

JO - American Journal of Physiology (Consolidated)

JF - American Journal of Physiology (Consolidated)

IS - 6 Pt 1

ER -