Genetic invalidation of Lp-PLA2 as a therapeutic target: Large-scale study of five functional Lp-PLA2-lowering alleles

John M Gregson; Daniel F Freitag; Praveen Surendran; Nathan O Stitziel; Rajiv Chowdhury; Stephen Burgess; Stephen Kaptoge; Pei Gao; James R Staley; Peter Willeit; Sune F Nielsen; Muriel Caslake; Stella Trompet; Linda M Polfus; Kari Kuulasmaa; Jukka Kontto; Markus Perola; Stefan Blankenberg; Giovanni Veronesi; Francesco Gianfagna; Satu Männistö; Akinori Kimura; Honghuang Lin; Dermot F Reilly; Mathias Gorski; Vladan Mijatovic; Patricia B Munroe; Georg B Ehret; Alex Thompson; Maria Uria-Nickelsen; Anders Malarstig; Abbas Dehghan; Thomas F Vogt; Taishi Sasaoka; Fumihiko Takeuchi; Norihiro Kato; Yoshiji Yamada; Frank Kee; Martina Müller-Nurasyid; Jean Ferrières; Dominique Arveiler; Philippe Amouyel; Veikko Salomaa; Eric Boerwinkle; Simon G Thompson; Ian Ford; J Wouter Jukema; Naveed Sattar; Chris J Packard; Abdulla Al Shafi Majumder; Dewan S Alam; Panos Deloukas; Heribert Schunkert; Nilesh J Samani; Sekar Kathiresan; Børge G Nordestgaard; Danish Saleheen; Joanna Mm Howson; Emanuele Di Angelantonio; Adam S Butterworth; John Danesh

doi:10.1177/2047487316682186

Genetic invalidation of Lp-PLA₂ as a therapeutic target: Large-scale study of five functional Lp-PLA₂-lowering alleles

John M Gregson, Daniel F Freitag, Praveen Surendran, Nathan O Stitziel, Rajiv Chowdhury, Stephen Burgess, Stephen Kaptoge, Pei Gao, James R Staley, Peter Willeit, Sune F Nielsen, Muriel Caslake, Stella Trompet, Linda M Polfus, Kari Kuulasmaa, Jukka Kontto, Markus Perola, Stefan Blankenberg, Giovanni Veronesi, Francesco GianfagnaSatu Männistö, Akinori Kimura, Honghuang Lin, Dermot F Reilly, Mathias Gorski, Vladan Mijatovic, Patricia B Munroe, Georg B Ehret, Alex Thompson, Maria Uria-Nickelsen, Anders Malarstig, Abbas Dehghan, Thomas F Vogt, Taishi Sasaoka, Fumihiko Takeuchi, Norihiro Kato, Yoshiji Yamada, Frank Kee, Martina Müller-Nurasyid, Jean Ferrières, Dominique Arveiler, Philippe Amouyel, Veikko Salomaa, Eric Boerwinkle, Simon G Thompson, Ian Ford, J Wouter Jukema, Naveed Sattar, Chris J Packard, Abdulla Al Shafi Majumder, Dewan S Alam, Panos Deloukas, Heribert Schunkert, Nilesh J Samani, Sekar Kathiresan, Børge G Nordestgaard, Danish Saleheen, Joanna Mm Howson, Emanuele Di Angelantonio, Adam S Butterworth, John Danesh

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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Originalsprog	Engelsk
Tidsskrift	European Journal of Preventive Cardiology
Vol/bind	24
Udgave nummer	5
Sider (fra-til)	492-504
ISSN	2047-4873
DOI	https://doi.org/10.1177/2047487316682186
Status	Udgivet - 2017

Adgang til dokumentet

10.1177/2047487316682186Licens: CC BY

2047487316682186Forlagets udgivne version, 284 KBLicens: CC BY

Citationsformater

Gregson, J. M., Freitag, D. F., Surendran, P., Stitziel, N. O., Chowdhury, R., Burgess, S., Kaptoge, S., Gao, P., Staley, J. R., Willeit, P., Nielsen, S. F., Caslake, M., Trompet, S., Polfus, L. M., Kuulasmaa, K., Kontto, J., Perola, M., Blankenberg, S., Veronesi, G., ... Danesh, J. (2017). Genetic invalidation of Lp-PLA₂ as a therapeutic target: Large-scale study of five functional Lp-PLA₂-lowering alleles. European Journal of Preventive Cardiology, 24(5), 492-504. https://doi.org/10.1177/2047487316682186

Gregson, JM, Freitag, DF, Surendran, P, Stitziel, NO, Chowdhury, R, Burgess, S, Kaptoge, S, Gao, P, Staley, JR, Willeit, P, Nielsen, SF, Caslake, M, Trompet, S, Polfus, LM, Kuulasmaa, K, Kontto, J, Perola, M, Blankenberg, S, Veronesi, G, Gianfagna, F, Männistö, S, Kimura, A, Lin, H, Reilly, DF, Gorski, M, Mijatovic, V, Munroe, PB, Ehret, GB, Thompson, A, Uria-Nickelsen, M, Malarstig, A, Dehghan, A, Vogt, TF, Sasaoka, T, Takeuchi, F, Kato, N, Yamada, Y, Kee, F, Müller-Nurasyid, M, Ferrières, J, Arveiler, D, Amouyel, P, Salomaa, V, Boerwinkle, E, Thompson, SG, Ford, I, Wouter Jukema, J, Sattar, N, Packard, CJ, Shafi Majumder, AA, Alam, DS, Deloukas, P, Schunkert, H, Samani, NJ, Kathiresan, S, Nordestgaard, BG, Saleheen, D, Howson, JM, Di Angelantonio, E, Butterworth, AS & Danesh, J 2017, 'Genetic invalidation of Lp-PLA₂ as a therapeutic target: Large-scale study of five functional Lp-PLA₂-lowering alleles', European Journal of Preventive Cardiology, bind 24, nr. 5, s. 492-504. https://doi.org/10.1177/2047487316682186

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title = "Genetic invalidation of Lp-PLA2 as a therapeutic target: Large-scale study of five functional Lp-PLA2-lowering alleles",

author = "Gregson, {John M} and Freitag, {Daniel F} and Praveen Surendran and Stitziel, {Nathan O} and Rajiv Chowdhury and Stephen Burgess and Stephen Kaptoge and Pei Gao and Staley, {James R} and Peter Willeit and Nielsen, {Sune F} and Muriel Caslake and Stella Trompet and Polfus, {Linda M} and Kari Kuulasmaa and Jukka Kontto and Markus Perola and Stefan Blankenberg and Giovanni Veronesi and Francesco Gianfagna and Satu M{\"a}nnist{\"o} and Akinori Kimura and Honghuang Lin and Reilly, {Dermot F} and Mathias Gorski and Vladan Mijatovic and Munroe, {Patricia B} and Ehret, {Georg B} and Alex Thompson and Maria Uria-Nickelsen and Anders Malarstig and Abbas Dehghan and Vogt, {Thomas F} and Taishi Sasaoka and Fumihiko Takeuchi and Norihiro Kato and Yoshiji Yamada and Frank Kee and Martina M{\"u}ller-Nurasyid and Jean Ferri{\`e}res and Dominique Arveiler and Philippe Amouyel and Veikko Salomaa and Eric Boerwinkle and Thompson, {Simon G} and Ian Ford and {Wouter Jukema}, J and Naveed Sattar and Packard, {Chris J} and {Shafi Majumder}, {Abdulla Al} and Alam, {Dewan S} and Panos Deloukas and Heribert Schunkert and Samani, {Nilesh J} and Sekar Kathiresan and Nordestgaard, {B{\o}rge G} and Danish Saleheen and Howson, {Joanna Mm} and {Di Angelantonio}, Emanuele and Butterworth, {Adam S} and John Danesh",

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AU - Gregson, John M

AU - Freitag, Daniel F

AU - Surendran, Praveen

AU - Stitziel, Nathan O

AU - Chowdhury, Rajiv

AU - Burgess, Stephen

AU - Kaptoge, Stephen

AU - Gao, Pei

AU - Staley, James R

AU - Willeit, Peter

AU - Nielsen, Sune F

AU - Caslake, Muriel

AU - Trompet, Stella

AU - Polfus, Linda M

AU - Kuulasmaa, Kari

AU - Kontto, Jukka

AU - Perola, Markus

AU - Blankenberg, Stefan

AU - Veronesi, Giovanni

AU - Gianfagna, Francesco

AU - Männistö, Satu

AU - Kimura, Akinori

AU - Lin, Honghuang

AU - Reilly, Dermot F

AU - Gorski, Mathias

AU - Mijatovic, Vladan

AU - Munroe, Patricia B

AU - Ehret, Georg B

AU - Thompson, Alex

AU - Uria-Nickelsen, Maria

AU - Malarstig, Anders

AU - Dehghan, Abbas

AU - Vogt, Thomas F

AU - Sasaoka, Taishi

AU - Takeuchi, Fumihiko

AU - Kato, Norihiro

AU - Yamada, Yoshiji

AU - Kee, Frank

AU - Müller-Nurasyid, Martina

AU - Ferrières, Jean

AU - Arveiler, Dominique

AU - Amouyel, Philippe

AU - Salomaa, Veikko

AU - Boerwinkle, Eric

AU - Thompson, Simon G

AU - Ford, Ian

AU - Wouter Jukema, J

AU - Sattar, Naveed

AU - Packard, Chris J

AU - Shafi Majumder, Abdulla Al

AU - Alam, Dewan S

AU - Deloukas, Panos

AU - Schunkert, Heribert

AU - Samani, Nilesh J

AU - Kathiresan, Sekar

AU - Nordestgaard, Børge G

AU - Saleheen, Danish

AU - Howson, Joanna Mm

AU - Di Angelantonio, Emanuele

AU - Butterworth, Adam S

AU - Danesh, John

PY - 2017

Y1 - 2017

U2 - 10.1177/2047487316682186

DO - 10.1177/2047487316682186

M3 - Journal article

C2 - 27940953

SN - 2047-4873

VL - 24

SP - 492

EP - 504

JO - European Journal of Preventive Cardiology

JF - European Journal of Preventive Cardiology

IS - 5

ER -