Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index

Rachel M Freathy; Gbenga R Kazeem; Richard W Morris; Paul C D Johnson; Lavinia Paternoster; Shah Ebrahim; Andrew T Hattersley; Anita Hill; Aroon D Hingorani; Claus Holst; Barbara J Jefferis; Sofia I I Kring; Vincent Mooser; Sandosh Padmanabhan; Martin Preisig; Susan M Ring; Naveed Sattar; Mark N Upton; Peter Vollenweider; Gerard Waeber; Thorkild I A Sørensen; Timothy M Frayling; Graham Watt; Debbie A Lawlor; Peter H Whincup; Federica Tozzi; George Davey Smith; Marcus Munafò

doi:10.1093/ije/dyr077

Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index

Rachel M Freathy, Gbenga R Kazeem, Richard W Morris, Paul C D Johnson, Lavinia Paternoster, Shah Ebrahim, Andrew T Hattersley, Anita Hill, Aroon D Hingorani, Claus Holst, Barbara J Jefferis, Sofia I I Kring, Vincent Mooser, Sandosh Padmanabhan, Martin Preisig, Susan M Ring, Naveed Sattar, Mark N Upton, Peter Vollenweider, Gerard WaeberThorkild I A Sørensen, Timothy M Frayling, Graham Watt, Debbie A Lawlor, Peter H Whincup, Federica Tozzi, George Davey Smith, Marcus Munafò

Institut for Folkesundhedsvidenskab

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

93 Citationer (Scopus)

Abstract

Cigarette smoking is associated with lower body mass index (BMI), and a commonly cited reason for unwillingness to quit smoking is a concern about weight gain. Common variation in the CHRNA5-CHRNA3-CHRNB4 gene region (chromosome 15q25) is robustly associated with smoking quantity in smokers, but its association with BMI is unknown. We hypothesized that genotype would accurately reflect smoking exposure and that, if smoking were causally related to weight, it would be associated with BMI in smokers, but not in never smokers.

Originalsprog	Engelsk
Tidsskrift	International Journal of Epidemiology
Vol/bind	40
Udgave nummer	6
Sider (fra-til)	1617-28
Antal sider	12
ISSN	0300-5771
DOI	https://doi.org/10.1093/ije/dyr077 https://doi.org/10.1093/ije/dyr077
Status	Udgivet - 2011

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Citationsformater

Freathy, R. M., Kazeem, G. R., Morris, R. W., Johnson, P. C. D., Paternoster, L., Ebrahim, S., Hattersley, A. T., Hill, A., Hingorani, A. D., Holst, C., Jefferis, B. J., Kring, S. I. I., Mooser, V., Padmanabhan, S., Preisig, M., Ring, S. M., Sattar, N., Upton, M. N., Vollenweider, P., ... Munafò, M. (2011). Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index. International Journal of Epidemiology, 40(6), 1617-28. https://doi.org/10.1093/ije/dyr077, https://doi.org/10.1093/ije/dyr077

Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index. / Freathy, Rachel M; Kazeem, Gbenga R; Morris, Richard W; Johnson, Paul C D; Paternoster, Lavinia; Ebrahim, Shah; Hattersley, Andrew T; Hill, Anita; Hingorani, Aroon D; Holst, Claus; Jefferis, Barbara J; Kring, Sofia I I; Mooser, Vincent; Padmanabhan, Sandosh; Preisig, Martin; Ring, Susan M; Sattar, Naveed; Upton, Mark N; Vollenweider, Peter; Waeber, Gerard; Sørensen, Thorkild I A; Frayling, Timothy M; Watt, Graham; Lawlor, Debbie A; Whincup, Peter H; Tozzi, Federica; Davey Smith, George; Munafò, Marcus.

I: International Journal of Epidemiology, Bind 40, Nr. 6, 2011, s. 1617-28.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Freathy, RM, Kazeem, GR, Morris, RW, Johnson, PCD, Paternoster, L, Ebrahim, S, Hattersley, AT, Hill, A, Hingorani, AD, Holst, C, Jefferis, BJ, Kring, SII, Mooser, V, Padmanabhan, S, Preisig, M, Ring, SM, Sattar, N, Upton, MN, Vollenweider, P, Waeber, G, Sørensen, TIA, Frayling, TM, Watt, G, Lawlor, DA, Whincup, PH, Tozzi, F, Davey Smith, G & Munafò, M 2011, 'Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index', International Journal of Epidemiology, bind 40, nr. 6, s. 1617-28. https://doi.org/10.1093/ije/dyr077, https://doi.org/10.1093/ije/dyr077

Freathy, Rachel M ; Kazeem, Gbenga R ; Morris, Richard W ; Johnson, Paul C D ; Paternoster, Lavinia ; Ebrahim, Shah ; Hattersley, Andrew T ; Hill, Anita ; Hingorani, Aroon D ; Holst, Claus ; Jefferis, Barbara J ; Kring, Sofia I I ; Mooser, Vincent ; Padmanabhan, Sandosh ; Preisig, Martin ; Ring, Susan M ; Sattar, Naveed ; Upton, Mark N ; Vollenweider, Peter ; Waeber, Gerard ; Sørensen, Thorkild I A ; Frayling, Timothy M ; Watt, Graham ; Lawlor, Debbie A ; Whincup, Peter H ; Tozzi, Federica ; Davey Smith, George ; Munafò, Marcus. / Genetic variation at CHRNA5-CHRNA3-CHRNB4 interacts with smoking status to influence body mass index. I: International Journal of Epidemiology. 2011 ; Bind 40, Nr. 6. s. 1617-28.

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abstract = "Cigarette smoking is associated with lower body mass index (BMI), and a commonly cited reason for unwillingness to quit smoking is a concern about weight gain. Common variation in the CHRNA5-CHRNA3-CHRNB4 gene region (chromosome 15q25) is robustly associated with smoking quantity in smokers, but its association with BMI is unknown. We hypothesized that genotype would accurately reflect smoking exposure and that, if smoking were causally related to weight, it would be associated with BMI in smokers, but not in never smokers.",

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AU - Freathy, Rachel M

AU - Kazeem, Gbenga R

AU - Morris, Richard W

AU - Johnson, Paul C D

AU - Paternoster, Lavinia

AU - Ebrahim, Shah

AU - Hattersley, Andrew T

AU - Hill, Anita

AU - Hingorani, Aroon D

AU - Holst, Claus

AU - Jefferis, Barbara J

AU - Kring, Sofia I I

AU - Mooser, Vincent

AU - Padmanabhan, Sandosh

AU - Preisig, Martin

AU - Ring, Susan M

AU - Sattar, Naveed

AU - Upton, Mark N

AU - Vollenweider, Peter

AU - Waeber, Gerard

AU - Sørensen, Thorkild I A

AU - Frayling, Timothy M

AU - Watt, Graham

AU - Lawlor, Debbie A

AU - Whincup, Peter H

AU - Tozzi, Federica

AU - Davey Smith, George

AU - Munafò, Marcus

PY - 2011

Y1 - 2011

N2 - Cigarette smoking is associated with lower body mass index (BMI), and a commonly cited reason for unwillingness to quit smoking is a concern about weight gain. Common variation in the CHRNA5-CHRNA3-CHRNB4 gene region (chromosome 15q25) is robustly associated with smoking quantity in smokers, but its association with BMI is unknown. We hypothesized that genotype would accurately reflect smoking exposure and that, if smoking were causally related to weight, it would be associated with BMI in smokers, but not in never smokers.

AB - Cigarette smoking is associated with lower body mass index (BMI), and a commonly cited reason for unwillingness to quit smoking is a concern about weight gain. Common variation in the CHRNA5-CHRNA3-CHRNB4 gene region (chromosome 15q25) is robustly associated with smoking quantity in smokers, but its association with BMI is unknown. We hypothesized that genotype would accurately reflect smoking exposure and that, if smoking were causally related to weight, it would be associated with BMI in smokers, but not in never smokers.

U2 - 10.1093/ije/dyr077

DO - 10.1093/ije/dyr077

M3 - Journal article

C2 - 21593077

VL - 40

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JO - International Journal of Epidemiology

JF - International Journal of Epidemiology

SN - 0300-5771

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