Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes

Suzanne Vogelezang; Jonathan P Bradfield; Early Growth Genetics Consortium; Tarun Veer Singh Ahluwalia; Xueping Liu; Theresia Maria Schnurr; Christine Frithioff-Bøjsøe; Klaus Bønnelykke; Mads Vendelbo Lind; Lotte Lauritzen; Kim F. Michaelsen; Morten Asp Vonsild Lund; Mads Melbye; Camilla Schmidt Morgen; Oluf Borbye Pedersen; Jens-Christian Holm; Niels Grarup; Torben Hansen; Ellen A Nohr; Hans Bisgaard; Struan F A Grant; Janine F Felix; Vincent W V Jaddoe

doi:10.1186/s12920-022-01281-1

Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes

Suzanne Vogelezang, Jonathan P Bradfield, Early Growth Genetics Consortium, Tarun Veer Singh Ahluwalia, Xueping Liu, Theresia Maria Schnurr, Christine Frithioff-Bøjsøe, Klaus Bønnelykke, Mads Vendelbo Lind, Lotte Lauritzen, Kim F. Michaelsen, Morten Asp Vonsild Lund, Mads Melbye, Camilla Schmidt Morgen, Oluf Borbye Pedersen, Jens-Christian Holm, Niels Grarup, Torben Hansen, Ellen A Nohr, Hans BisgaardStruan F A Grant, Janine F Felix, Vincent W V Jaddoe^*

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

4 Citationer (Scopus)

41 Downloads (Pure)

Abstract

Background: Head circumference is associated with intelligence and tracks from childhood into adulthood.

Methods: We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age.

Results: Seven loci reached genome-wide significance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes.

Conclusions: The results of this study indicate that the biological processes underlying early-life head circumference overlap largely with those of adult head circumference. The associations of early-life head circumference with cognitive outcomes across the life course are partly explained by genetics.

Originalsprog	Engelsk
Artikelnummer	124
Tidsskrift	BMC Medical Genomics
Vol/bind	15
Antal sider	16
ISSN	1755-8794
DOI	https://doi.org/10.1186/s12920-022-01281-1
Status	Udgivet - 2022

Bibliografisk note

CURIS 2022 NEXS 148
© 2022. The Author(s).

Adgang til dokumentet

10.1186/s12920-022-01281-1Licens: CC BY

Vogelezang et al_BMC Medical Genomics_2022_Vol 15_e124Forlagets udgivne version, 1,46 MBLicens: CC BY

Citationsformater

Vogelezang, S., Bradfield, J. P., Early Growth Genetics Consortium, Ahluwalia, T. V. S., Liu, X., Schnurr, T. M., Frithioff-Bøjsøe, C., Bønnelykke, K., Lind, M. V., Lauritzen, L., Michaelsen, K. F., Lund, M. A. V., Melbye, M., Morgen, C. S., Pedersen, O. B., Holm, J.-C., Grarup, N., Hansen, T., Nohr, E. A., ... Jaddoe, V. W. V. (2022). Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes. BMC Medical Genomics, 15, Artikel 124. https://doi.org/10.1186/s12920-022-01281-1

Vogelezang, S, Bradfield, JP, Early Growth Genetics Consortium, Ahluwalia, TVS, Liu, X, Schnurr, TM, Frithioff-Bøjsøe, C, Bønnelykke, K, Lind, MV, Lauritzen, L , Michaelsen, KF , Lund, MAV, Melbye, M, Morgen, CS, Pedersen, OB , Holm, J-C, Grarup, N, Hansen, T, Nohr, EA, Bisgaard, H, Grant, SFA, Felix, JF & Jaddoe, VWV 2022, 'Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes', BMC Medical Genomics, bind 15, 124. https://doi.org/10.1186/s12920-022-01281-1

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title = "Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes",

abstract = "Background: Head circumference is associated with intelligence and tracks from childhood into adulthood.Methods: We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age.Results: Seven loci reached genome-wide significance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes.Conclusions: The results of this study indicate that the biological processes underlying early-life head circumference overlap largely with those of adult head circumference. The associations of early-life head circumference with cognitive outcomes across the life course are partly explained by genetics.",

keywords = "Head circumference, Infancy, Genetic correlations, Genome-Wide Association Study",

author = "Suzanne Vogelezang and Bradfield, {Jonathan P} and {Early Growth Genetics Consortium} and Ahluwalia, {Tarun Veer Singh} and Xueping Liu and Schnurr, {Theresia Maria} and Christine Frithioff-B{\o}js{\o}e and Klaus B{\o}nnelykke and Lind, {Mads Vendelbo} and Lotte Lauritzen and Michaelsen, {Kim F.} and Lund, {Morten Asp Vonsild} and Mads Melbye and Morgen, {Camilla Schmidt} and Pedersen, {Oluf Borbye} and Jens-Christian Holm and Niels Grarup and Torben Hansen and Nohr, {Ellen A} and Hans Bisgaard and Grant, {Struan F A} and Felix, {Janine F} and Jaddoe, {Vincent W V}",

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volume = "15",

journal = "BMC Medical Genomics",

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T1 - Genetics of early-life head circumference and genetic correlations with neurological, psychiatric and cognitive outcomes

AU - Vogelezang, Suzanne

AU - Bradfield, Jonathan P

AU - Early Growth Genetics Consortium

AU - Ahluwalia, Tarun Veer Singh

AU - Liu, Xueping

AU - Schnurr, Theresia Maria

AU - Frithioff-Bøjsøe, Christine

AU - Bønnelykke, Klaus

AU - Lind, Mads Vendelbo

AU - Lauritzen, Lotte

AU - Michaelsen, Kim F.

AU - Lund, Morten Asp Vonsild

AU - Melbye, Mads

AU - Morgen, Camilla Schmidt

AU - Pedersen, Oluf Borbye

AU - Holm, Jens-Christian

AU - Grarup, Niels

AU - Hansen, Torben

AU - Nohr, Ellen A

AU - Bisgaard, Hans

AU - Grant, Struan F A

AU - Felix, Janine F

AU - Jaddoe, Vincent W V

PY - 2022

Y1 - 2022

N2 - Background: Head circumference is associated with intelligence and tracks from childhood into adulthood.Methods: We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age.Results: Seven loci reached genome-wide significance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes.Conclusions: The results of this study indicate that the biological processes underlying early-life head circumference overlap largely with those of adult head circumference. The associations of early-life head circumference with cognitive outcomes across the life course are partly explained by genetics.

AB - Background: Head circumference is associated with intelligence and tracks from childhood into adulthood.Methods: We performed a genome-wide association study meta-analysis and follow-up of head circumference in a total of 29,192 participants between 6 and 30 months of age.Results: Seven loci reached genome-wide significance in the combined discovery and replication analysis of which three loci near ARFGEF2, MYCL1, and TOP1, were novel. We observed positive genetic correlations for early-life head circumference with adult intracranial volume, years of schooling, childhood and adult intelligence, but not with adult psychiatric, neurological, or personality-related phenotypes.Conclusions: The results of this study indicate that the biological processes underlying early-life head circumference overlap largely with those of adult head circumference. The associations of early-life head circumference with cognitive outcomes across the life course are partly explained by genetics.

KW - Head circumference

KW - Infancy

KW - Genetic correlations

KW - Genome-Wide Association Study

U2 - 10.1186/s12920-022-01281-1

DO - 10.1186/s12920-022-01281-1

M3 - Journal article

C2 - 35659227

SN - 1755-8794

VL - 15

JO - BMC Medical Genomics

JF - BMC Medical Genomics

M1 - 124

ER -