Genome-wide analysis of DNA methylation differences in muscle and fat from monozygotic twins discordant for type 2 diabetes

Rasmus Ribel-Madsen; Mario F Fraga; Stine Jacobsen; Jette Bork-Jensen; Ester Lara; Vincenzo Calvanese; Agustin F Fernandez; Martin Friedrichsen; Birgitte Falbe Vind; Kurt Højlund; Henning Beck-Nielsen; Manel Esteller; Allan Vaag; Pernille Poulsen

doi:10.1371/journal.pone.0051302

Genome-wide analysis of DNA methylation differences in muscle and fat from monozygotic twins discordant for type 2 diabetes

Rasmus Ribel-Madsen, Mario F Fraga, Stine Jacobsen, Jette Bork-Jensen, Ester Lara, Vincenzo Calvanese, Agustin F Fernandez, Martin Friedrichsen, Birgitte Falbe Vind, Kurt Højlund, Henning Beck-Nielsen, Manel Esteller, Allan Vaag, Pernille Poulsen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

174 Citationer (Scopus)

Abstract

Monozygotic twins discordant for type 2 diabetes constitute an ideal model to study environmental contributions to type 2 diabetic traits. We aimed to examine whether global DNA methylation differences exist in major glucose metabolic tissues from these twins.

Originalsprog	Engelsk
Tidsskrift	P L o S One
Vol/bind	7
Udgave nummer	12
Sider (fra-til)	e51302
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0051302
Status	Udgivet - 2012

Bibliografisk note

CURIS 2012 5200 168

Adgang til dokumentet

10.1371/journal.pone.0051302

Citationsformater

Ribel-Madsen, R., Fraga, M. F., Jacobsen, S., Bork-Jensen, J., Lara, E., Calvanese, V., Fernandez, A. F., Friedrichsen, M., Vind, B. F., Højlund, K., Beck-Nielsen, H., Esteller, M., Vaag, A., & Poulsen, P. (2012). Genome-wide analysis of DNA methylation differences in muscle and fat from monozygotic twins discordant for type 2 diabetes. P L o S One, 7(12), e51302. https://doi.org/10.1371/journal.pone.0051302

Ribel-Madsen, R, Fraga, MF, Jacobsen, S, Bork-Jensen, J, Lara, E, Calvanese, V, Fernandez, AF, Friedrichsen, M, Vind, BF, Højlund, K, Beck-Nielsen, H, Esteller, M, Vaag, A & Poulsen, P 2012, 'Genome-wide analysis of DNA methylation differences in muscle and fat from monozygotic twins discordant for type 2 diabetes', P L o S One, bind 7, nr. 12, s. e51302. https://doi.org/10.1371/journal.pone.0051302

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abstract = "Monozygotic twins discordant for type 2 diabetes constitute an ideal model to study environmental contributions to type 2 diabetic traits. We aimed to examine whether global DNA methylation differences exist in major glucose metabolic tissues from these twins.",

author = "Rasmus Ribel-Madsen and Fraga, {Mario F} and Stine Jacobsen and Jette Bork-Jensen and Ester Lara and Vincenzo Calvanese and Fernandez, {Agustin F} and Martin Friedrichsen and Vind, {Birgitte Falbe} and Kurt H{\o}jlund and Henning Beck-Nielsen and Manel Esteller and Allan Vaag and Pernille Poulsen",

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AU - Ribel-Madsen, Rasmus

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AU - Bork-Jensen, Jette

AU - Lara, Ester

AU - Calvanese, Vincenzo

AU - Fernandez, Agustin F

AU - Friedrichsen, Martin

AU - Vind, Birgitte Falbe

AU - Højlund, Kurt

AU - Beck-Nielsen, Henning

AU - Esteller, Manel

AU - Vaag, Allan

AU - Poulsen, Pernille

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N2 - Monozygotic twins discordant for type 2 diabetes constitute an ideal model to study environmental contributions to type 2 diabetic traits. We aimed to examine whether global DNA methylation differences exist in major glucose metabolic tissues from these twins.

AB - Monozygotic twins discordant for type 2 diabetes constitute an ideal model to study environmental contributions to type 2 diabetic traits. We aimed to examine whether global DNA methylation differences exist in major glucose metabolic tissues from these twins.

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M3 - Journal article

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