Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

Jeffrey C Barrett; David G Clayton; Patrick Concannon; Beena Akolkar; Jason D Cooper; Henry A Erlich; Cécile Julier; Grant Morahan; Jørn Nerup; Concepcion Nierras; Vincent Plagnol; Flemming Pociot; Helen Schuilenburg; Deborah J Smyth; Helen Stevens; John A Todd; Neil M Walker; Stephen S Rich; The Type 1 Diabetes Genetics Consortium

doi:10.1038/ng.381

Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

Jeffrey C Barrett, David G Clayton, Patrick Concannon, Beena Akolkar, Jason D Cooper, Henry A Erlich, Cécile Julier, Grant Morahan, Jørn Nerup, Concepcion Nierras, Vincent Plagnol, Flemming Pociot, Helen Schuilenburg, Deborah J Smyth, Helen Stevens, John A Todd, Neil M Walker, Stephen S Rich, The Type 1 Diabetes Genetics Consortium

Ph.d.-studienævnet for Medicin

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

1433 Citationer (Scopus)

Abstract

Udgivelsesdato: 2009-May

Originalsprog	Engelsk
Tidsskrift	Nature Genetics
ISSN	1061-4036
DOI	https://doi.org/10.1038/ng.381
Status	Udgivet - 2009

Adgang til dokumentet

10.1038/ng.381

Citationsformater

Barrett, J. C., Clayton, D. G., Concannon, P., Akolkar, B., Cooper, J. D., Erlich, H. A., Julier, C., Morahan, G., Nerup, J., Nierras, C., Plagnol, V., Pociot, F., Schuilenburg, H., Smyth, D. J., Stevens, H., Todd, J. A., Walker, N. M., Rich, S. S., & The Type 1 Diabetes Genetics Consortium (2009). Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nature Genetics. https://doi.org/10.1038/ng.381

Barrett, JC, Clayton, DG, Concannon, P, Akolkar, B, Cooper, JD, Erlich, HA, Julier, C, Morahan, G, Nerup, J, Nierras, C, Plagnol, V, Pociot, F, Schuilenburg, H, Smyth, DJ, Stevens, H, Todd, JA, Walker, NM, Rich, SS & The Type 1 Diabetes Genetics Consortium 2009, 'Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes', Nature Genetics. https://doi.org/10.1038/ng.381

@article{b5201af09fa311df928f000ea68e967b,

title = "Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes",

abstract = "Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the action of multiple genetic and environmental risk factors. We report the findings of a genome-wide association study of T1D, combined in a meta-analysis with two previously published studies. The total sample set included 7,514 cases and 9,045 reference samples. Forty-one distinct genomic locations provided evidence for association with T1D in the meta-analysis (P < 10(-6)). After excluding previously reported associations, we further tested 27 regions in an independent set of 4,267 cases, 4,463 controls and 2,319 affected sib-pair (ASP) families. Of these, 18 regions were replicated (P < 0.01; overall P < 5 x 10(-8)) and 4 additional regions provided nominal evidence of replication (P < 0.05). The many new candidate genes suggested by these results include IL10, IL19, IL20, GLIS3, CD69 and IL27.",

author = "Barrett, {Jeffrey C} and Clayton, {David G} and Patrick Concannon and Beena Akolkar and Cooper, {Jason D} and Erlich, {Henry A} and C{\'e}cile Julier and Grant Morahan and J{\o}rn Nerup and Concepcion Nierras and Vincent Plagnol and Flemming Pociot and Helen Schuilenburg and Smyth, {Deborah J} and Helen Stevens and Todd, {John A} and Walker, {Neil M} and Rich, {Stephen S} and {The Type 1 Diabetes Genetics Consortium}",

year = "2009",

doi = "10.1038/ng.381",

language = "English",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "nature publishing group",

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TY - JOUR

T1 - Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes

AU - Barrett, Jeffrey C

AU - Clayton, David G

AU - Concannon, Patrick

AU - Akolkar, Beena

AU - Cooper, Jason D

AU - Erlich, Henry A

AU - Julier, Cécile

AU - Morahan, Grant

AU - Nerup, Jørn

AU - Nierras, Concepcion

AU - Plagnol, Vincent

AU - Pociot, Flemming

AU - Schuilenburg, Helen

AU - Smyth, Deborah J

AU - Stevens, Helen

AU - Todd, John A

AU - Walker, Neil M

AU - Rich, Stephen S

AU - The Type 1 Diabetes Genetics Consortium

PY - 2009

Y1 - 2009

N2 - Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the action of multiple genetic and environmental risk factors. We report the findings of a genome-wide association study of T1D, combined in a meta-analysis with two previously published studies. The total sample set included 7,514 cases and 9,045 reference samples. Forty-one distinct genomic locations provided evidence for association with T1D in the meta-analysis (P < 10(-6)). After excluding previously reported associations, we further tested 27 regions in an independent set of 4,267 cases, 4,463 controls and 2,319 affected sib-pair (ASP) families. Of these, 18 regions were replicated (P < 0.01; overall P < 5 x 10(-8)) and 4 additional regions provided nominal evidence of replication (P < 0.05). The many new candidate genes suggested by these results include IL10, IL19, IL20, GLIS3, CD69 and IL27.

AB - Type 1 diabetes (T1D) is a common autoimmune disorder that arises from the action of multiple genetic and environmental risk factors. We report the findings of a genome-wide association study of T1D, combined in a meta-analysis with two previously published studies. The total sample set included 7,514 cases and 9,045 reference samples. Forty-one distinct genomic locations provided evidence for association with T1D in the meta-analysis (P < 10(-6)). After excluding previously reported associations, we further tested 27 regions in an independent set of 4,267 cases, 4,463 controls and 2,319 affected sib-pair (ASP) families. Of these, 18 regions were replicated (P < 0.01; overall P < 5 x 10(-8)) and 4 additional regions provided nominal evidence of replication (P < 0.05). The many new candidate genes suggested by these results include IL10, IL19, IL20, GLIS3, CD69 and IL27.

U2 - 10.1038/ng.381

DO - 10.1038/ng.381

M3 - Journal article

C2 - 19430480

SN - 1061-4036

JO - Nature Genetics

JF - Nature Genetics

ER -