Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma

James R. Cerhan; Sonja I. Berndt; Joseph Vijai; Hervé Ghesquières; James McKay; Sophia S. Wang; Zhaoming Wang; Meredith Yeager; Lucia Conde; Paul I.W. De Bakker; Alexandra Nieters; David Cox; Laurie Burdett; Alain Monnereau; Christopher R. Flowers; Anneclaire J. De Roos; Angela R. Brooks-Wilson; Qing Lan; Gianluca Severi; Mads Melbye; Jian Gu; Rebecca D. Jackson; Eleanor Kane; Lauren R. Teras; Mark P. Purdue; Claire M. Vajdic; John J. Spinelli; Graham G. Giles; Demetrius Albanes; Rachel S. Kelly; Mariagrazia Zucca; Kimberly A. Bertrand; Anne Zeleniuch-Jacquotte; Charles Lawrence; Amy Hutchinson; Degui Zhi; Thomas M. Habermann; Brian K. Link; Anne J. Novak; Ahmet Dogan; Yan W. Asmann; Mark Liebow; Carrie A. Thompson; Stephen M. Ansell; Thomas E. Witzig; George J. Weiner; Amelie S. Veron; Diana Zelenika; Henrik Hjalgrim; Anne Tjonneland

doi:10.1038/ng.3105

Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma

James R. Cerhan^*, Sonja I. Berndt, Joseph Vijai, Hervé Ghesquières, James McKay, Sophia S. Wang, Zhaoming Wang, Meredith Yeager, Lucia Conde, Paul I.W. De Bakker, Alexandra Nieters, David Cox, Laurie Burdett, Alain Monnereau, Christopher R. Flowers, Anneclaire J. De Roos, Angela R. Brooks-Wilson, Qing Lan, Gianluca Severi, Mads MelbyeJian Gu, Rebecca D. Jackson, Eleanor Kane, Lauren R. Teras, Mark P. Purdue, Claire M. Vajdic, John J. Spinelli, Graham G. Giles, Demetrius Albanes, Rachel S. Kelly, Mariagrazia Zucca, Kimberly A. Bertrand, Anne Zeleniuch-Jacquotte, Charles Lawrence, Amy Hutchinson, Degui Zhi, Thomas M. Habermann, Brian K. Link, Anne J. Novak, Ahmet Dogan, Yan W. Asmann, Mark Liebow, Carrie A. Thompson, Stephen M. Ansell, Thomas E. Witzig, George J. Weiner, Amelie S. Veron, Diana Zelenika, Henrik Hjalgrim, Anne Tjonneland

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

145 Citationer (Scopus)

Abstract

Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs116446171 at 6p25.3 (EXOC2; P = 2.33 × 10 '21), rs2523607 at 6p21.33 (HLA-B; P = 2.40 × 10 '10), rs79480871 at 2p23.3 (NCOA1; P = 4.23 × 10 '8) and two independent SNPs, rs13255292 and rs4733601, at 8q24.21 (PVT1; P = 9.98 × 10 '13 and 3.63 × 10 '11, respectively). These data provide substantial new evidence for genetic susceptibility to this B cell malignancy and point to pathways involved in immune recognition and immune function in the pathogenesis of DLBCL.

Originalsprog	Engelsk
Tidsskrift	Nature Genetics
Vol/bind	46
Udgave nummer	11
Sider (fra-til)	1233-1238
Antal sider	6
ISSN	1061-4036
DOI	https://doi.org/10.1038/ng.3105
Status	Udgivet - 5 nov. 2014
Udgivet eksternt	Ja

Adgang til dokumentet

10.1038/ng.3105

Citationsformater

Cerhan, J. R., Berndt, S. I., Vijai, J., Ghesquières, H., McKay, J., Wang, S. S., Wang, Z., Yeager, M., Conde, L., De Bakker, P. I. W., Nieters, A., Cox, D., Burdett, L., Monnereau, A., Flowers, C. R., De Roos, A. J., Brooks-Wilson, A. R., Lan, Q., Severi, G., ... Tjonneland, A. (2014). Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma. Nature Genetics, 46(11), 1233-1238. https://doi.org/10.1038/ng.3105

Cerhan, JR, Berndt, SI, Vijai, J, Ghesquières, H, McKay, J, Wang, SS, Wang, Z, Yeager, M, Conde, L, De Bakker, PIW, Nieters, A, Cox, D, Burdett, L, Monnereau, A, Flowers, CR, De Roos, AJ, Brooks-Wilson, AR, Lan, Q, Severi, G, Melbye, M, Gu, J, Jackson, RD, Kane, E, Teras, LR, Purdue, MP, Vajdic, CM, Spinelli, JJ, Giles, GG, Albanes, D, Kelly, RS, Zucca, M, Bertrand, KA, Zeleniuch-Jacquotte, A, Lawrence, C, Hutchinson, A, Zhi, D, Habermann, TM, Link, BK, Novak, AJ, Dogan, A, Asmann, YW, Liebow, M, Thompson, CA, Ansell, SM, Witzig, TE, Weiner, GJ, Veron, AS, Zelenika, D, Hjalgrim, H & Tjonneland, A 2014, 'Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma', Nature Genetics, bind 46, nr. 11, s. 1233-1238. https://doi.org/10.1038/ng.3105

@article{149d9d732b2e412ebeca62a43ef3c740,

title = "Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma",

abstract = "Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs116446171 at 6p25.3 (EXOC2; P = 2.33 × 10 '21), rs2523607 at 6p21.33 (HLA-B; P = 2.40 × 10 '10), rs79480871 at 2p23.3 (NCOA1; P = 4.23 × 10 '8) and two independent SNPs, rs13255292 and rs4733601, at 8q24.21 (PVT1; P = 9.98 × 10 '13 and 3.63 × 10 '11, respectively). These data provide substantial new evidence for genetic susceptibility to this B cell malignancy and point to pathways involved in immune recognition and immune function in the pathogenesis of DLBCL.",

author = "Cerhan, {James R.} and Berndt, {Sonja I.} and Joseph Vijai and Herv{\'e} Ghesqui{\`e}res and James McKay and Wang, {Sophia S.} and Zhaoming Wang and Meredith Yeager and Lucia Conde and {De Bakker}, {Paul I.W.} and Alexandra Nieters and David Cox and Laurie Burdett and Alain Monnereau and Flowers, {Christopher R.} and {De Roos}, {Anneclaire J.} and Brooks-Wilson, {Angela R.} and Qing Lan and Gianluca Severi and Mads Melbye and Jian Gu and Jackson, {Rebecca D.} and Eleanor Kane and Teras, {Lauren R.} and Purdue, {Mark P.} and Vajdic, {Claire M.} and Spinelli, {John J.} and Giles, {Graham G.} and Demetrius Albanes and Kelly, {Rachel S.} and Mariagrazia Zucca and Bertrand, {Kimberly A.} and Anne Zeleniuch-Jacquotte and Charles Lawrence and Amy Hutchinson and Degui Zhi and Habermann, {Thomas M.} and Link, {Brian K.} and Novak, {Anne J.} and Ahmet Dogan and Asmann, {Yan W.} and Mark Liebow and Thompson, {Carrie A.} and Ansell, {Stephen M.} and Witzig, {Thomas E.} and Weiner, {George J.} and Veron, {Amelie S.} and Diana Zelenika and Henrik Hjalgrim and Anne Tjonneland",

year = "2014",

month = nov,

day = "5",

doi = "10.1038/ng.3105",

language = "English",

volume = "46",

pages = "1233--1238",

journal = "Nature Genetics",

issn = "1061-4036",

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T1 - Genome-wide association study identifies multiple susceptibility loci for diffuse large B cell lymphoma

AU - Cerhan, James R.

AU - Berndt, Sonja I.

AU - Vijai, Joseph

AU - Ghesquières, Hervé

AU - McKay, James

AU - Wang, Sophia S.

AU - Wang, Zhaoming

AU - Yeager, Meredith

AU - Conde, Lucia

AU - De Bakker, Paul I.W.

AU - Nieters, Alexandra

AU - Cox, David

AU - Burdett, Laurie

AU - Monnereau, Alain

AU - Flowers, Christopher R.

AU - De Roos, Anneclaire J.

AU - Brooks-Wilson, Angela R.

AU - Lan, Qing

AU - Severi, Gianluca

AU - Melbye, Mads

AU - Gu, Jian

AU - Jackson, Rebecca D.

AU - Kane, Eleanor

AU - Teras, Lauren R.

AU - Purdue, Mark P.

AU - Vajdic, Claire M.

AU - Spinelli, John J.

AU - Giles, Graham G.

AU - Albanes, Demetrius

AU - Kelly, Rachel S.

AU - Zucca, Mariagrazia

AU - Bertrand, Kimberly A.

AU - Zeleniuch-Jacquotte, Anne

AU - Lawrence, Charles

AU - Hutchinson, Amy

AU - Zhi, Degui

AU - Habermann, Thomas M.

AU - Link, Brian K.

AU - Novak, Anne J.

AU - Dogan, Ahmet

AU - Asmann, Yan W.

AU - Liebow, Mark

AU - Thompson, Carrie A.

AU - Ansell, Stephen M.

AU - Witzig, Thomas E.

AU - Weiner, George J.

AU - Veron, Amelie S.

AU - Zelenika, Diana

AU - Hjalgrim, Henrik

AU - Tjonneland, Anne

PY - 2014/11/5

Y1 - 2014/11/5

N2 - Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs116446171 at 6p25.3 (EXOC2; P = 2.33 × 10 '21), rs2523607 at 6p21.33 (HLA-B; P = 2.40 × 10 '10), rs79480871 at 2p23.3 (NCOA1; P = 4.23 × 10 '8) and two independent SNPs, rs13255292 and rs4733601, at 8q24.21 (PVT1; P = 9.98 × 10 '13 and 3.63 × 10 '11, respectively). These data provide substantial new evidence for genetic susceptibility to this B cell malignancy and point to pathways involved in immune recognition and immune function in the pathogenesis of DLBCL.

AB - Diffuse large B cell lymphoma (DLBCL) is the most common lymphoma subtype and is clinically aggressive. To identify genetic susceptibility loci for DLBCL, we conducted a meta-analysis of 3 new genome-wide association studies (GWAS) and 1 previous scan, totaling 3,857 cases and 7,666 controls of European ancestry, with additional genotyping of 9 promising SNPs in 1,359 cases and 4,557 controls. In our multi-stage analysis, five independent SNPs in four loci achieved genome-wide significance marked by rs116446171 at 6p25.3 (EXOC2; P = 2.33 × 10 '21), rs2523607 at 6p21.33 (HLA-B; P = 2.40 × 10 '10), rs79480871 at 2p23.3 (NCOA1; P = 4.23 × 10 '8) and two independent SNPs, rs13255292 and rs4733601, at 8q24.21 (PVT1; P = 9.98 × 10 '13 and 3.63 × 10 '11, respectively). These data provide substantial new evidence for genetic susceptibility to this B cell malignancy and point to pathways involved in immune recognition and immune function in the pathogenesis of DLBCL.

U2 - 10.1038/ng.3105

DO - 10.1038/ng.3105

M3 - Journal article

C2 - 25261932

AN - SCOPUS:84908886283

SN - 1061-4036

VL - 46

SP - 1233

EP - 1238

JO - Nature Genetics

JF - Nature Genetics

IS - 11

ER -