Genome-wide population-based association study of extremely overweight young adults--the GOYA study

Lavinia Paternoster; David M Evans; Ellen Aagaard Nohr; Claus Holst; Valerie Gaborieau; Paul Brennan; Anette Prior Gjesing; Niels Grarup; Daniel R Witte; Torben Jørgensen; Allan René Linneberg; Torsten Lauritzen; Anelli Sandbaek; Torben Hansen; Oluf Borbye Pedersen; Katherine S Elliott; John P Kemp; Beate St Pourcain; George McMahon; Diana Zelenika; Jörg Hager; Mark Lathrop; Nicholas J Timpson; George Davey Smith; Thorkild I A Sørensen

doi:10.1371/journal.pone.0024303

Genome-wide population-based association study of extremely overweight young adults--the GOYA study

Lavinia Paternoster, David M Evans, Ellen Aagaard Nohr, Claus Holst, Valerie Gaborieau, Paul Brennan, Anette Prior Gjesing, Niels Grarup, Daniel R Witte, Torben Jørgensen, Allan René Linneberg, Torsten Lauritzen, Anelli Sandbaek, Torben Hansen, Oluf Borbye Pedersen, Katherine S Elliott, John P Kemp, Beate St Pourcain, George McMahon, Diana ZelenikaJörg Hager, Mark Lathrop, Nicholas J Timpson, George Davey Smith, Thorkild I A Sørensen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

86 Citationer (Scopus)

Abstract

Thirty-two common variants associated with body mass index (BMI) have been identified in genome-wide association studies, explaining ∼1.45% of BMI variation in general population cohorts. We performed a genome-wide association study in a sample of young adults enriched for extremely overweight individuals. We aimed to identify new loci associated with BMI and to ascertain whether using an extreme sampling design would identify the variants known to be associated with BMI in general populations.

Originalsprog	Engelsk
Artikelnummer	e24303
Tidsskrift	P L o S One
Vol/bind	6
Udgave nummer	9
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0024303
Status	Udgivet - 2011

Adgang til dokumentet

10.1371/journal.pone.0024303

Citationsformater

Paternoster, L., Evans, D. M., Nohr, E. A., Holst, C., Gaborieau, V., Brennan, P., Gjesing, A. P., Grarup, N., Witte, D. R., Jørgensen, T., Linneberg, A. R., Lauritzen, T., Sandbaek, A., Hansen, T., Pedersen, O. B., Elliott, K. S., Kemp, J. P., St Pourcain, B., McMahon, G., ... Sørensen, T. I. A. (2011). Genome-wide population-based association study of extremely overweight young adults--the GOYA study. P L o S One, 6(9), [e24303]. https://doi.org/10.1371/journal.pone.0024303

Genome-wide population-based association study of extremely overweight young adults--the GOYA study. / Paternoster, Lavinia; Evans, David M; Nohr, Ellen Aagaard; Holst, Claus; Gaborieau, Valerie; Brennan, Paul; Gjesing, Anette Prior; Grarup, Niels; Witte, Daniel R; Jørgensen, Torben; Linneberg, Allan René; Lauritzen, Torsten; Sandbaek, Anelli; Hansen, Torben; Pedersen, Oluf Borbye; Elliott, Katherine S; Kemp, John P; St Pourcain, Beate; McMahon, George; Zelenika, Diana; Hager, Jörg; Lathrop, Mark; Timpson, Nicholas J; Smith, George Davey; Sørensen, Thorkild I A.

I: P L o S One, Bind 6, Nr. 9, e24303, 2011.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Paternoster, L, Evans, DM, Nohr, EA, Holst, C, Gaborieau, V, Brennan, P, Gjesing, AP, Grarup, N, Witte, DR, Jørgensen, T, Linneberg, AR, Lauritzen, T, Sandbaek, A, Hansen, T, Pedersen, OB, Elliott, KS, Kemp, JP, St Pourcain, B, McMahon, G, Zelenika, D, Hager, J, Lathrop, M, Timpson, NJ, Smith, GD & Sørensen, TIA 2011, 'Genome-wide population-based association study of extremely overweight young adults--the GOYA study', P L o S One, bind 6, nr. 9, e24303. https://doi.org/10.1371/journal.pone.0024303

Paternoster, Lavinia ; Evans, David M ; Nohr, Ellen Aagaard ; Holst, Claus ; Gaborieau, Valerie ; Brennan, Paul ; Gjesing, Anette Prior ; Grarup, Niels ; Witte, Daniel R ; Jørgensen, Torben ; Linneberg, Allan René ; Lauritzen, Torsten ; Sandbaek, Anelli ; Hansen, Torben ; Pedersen, Oluf Borbye ; Elliott, Katherine S ; Kemp, John P ; St Pourcain, Beate ; McMahon, George ; Zelenika, Diana ; Hager, Jörg ; Lathrop, Mark ; Timpson, Nicholas J ; Smith, George Davey ; Sørensen, Thorkild I A. / Genome-wide population-based association study of extremely overweight young adults--the GOYA study. I: P L o S One. 2011 ; Bind 6, Nr. 9.

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abstract = "Thirty-two common variants associated with body mass index (BMI) have been identified in genome-wide association studies, explaining ∼1.45% of BMI variation in general population cohorts. We performed a genome-wide association study in a sample of young adults enriched for extremely overweight individuals. We aimed to identify new loci associated with BMI and to ascertain whether using an extreme sampling design would identify the variants known to be associated with BMI in general populations.",

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AU - Brennan, Paul

AU - Gjesing, Anette Prior

AU - Grarup, Niels

AU - Witte, Daniel R

AU - Jørgensen, Torben

AU - Linneberg, Allan René

AU - Lauritzen, Torsten

AU - Sandbaek, Anelli

AU - Hansen, Torben

AU - Pedersen, Oluf Borbye

AU - Elliott, Katherine S

AU - Kemp, John P

AU - St Pourcain, Beate

AU - McMahon, George

AU - Zelenika, Diana

AU - Hager, Jörg

AU - Lathrop, Mark

AU - Timpson, Nicholas J

AU - Smith, George Davey

AU - Sørensen, Thorkild I A

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AB - Thirty-two common variants associated with body mass index (BMI) have been identified in genome-wide association studies, explaining ∼1.45% of BMI variation in general population cohorts. We performed a genome-wide association study in a sample of young adults enriched for extremely overweight individuals. We aimed to identify new loci associated with BMI and to ascertain whether using an extreme sampling design would identify the variants known to be associated with BMI in general populations.

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