Genomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, India

Mahesh S. Dhar; Robin Marwal; V. S. Radhakrishnan; Kalaiarasan Ponnusamy; Bani Jolly; Rahul C. Bhoyar; Viren Sardana; Salwa Naushin; Mercy Rophina; Thomas A. Mellan; Swapnil Mishra; Charles Whittaker; Saman Fatihi; Meena Datta; Priyanka Singh; Uma Sharma; Rajat Ujjainiya; Nitin Bhatheja; Mohit Kumar Divakar; Manoj K. Singh; Mohamed Imran; Vigneshwar Senthivel; Ranjeet Maurya; Neha Jha; Priyanka Mehta; A. Vivekanand; Pooja Sharma; V. R. Arvinden; Urmila Chaudhary; Namita Soni; Lipi Thukral; Seth Flaxman; Samir Bhatt; Rajesh Pandey; Debasis Dash; Mohammed Faruq; Hemlata Lall; Hema Gogia; Preeti Madan; Sanket Kulkarni; Himanshu Chauhan; Shantanu Sengupta; Sandhya Kabra; Ravindra K. Gupta; Sujeet K. Singh; Anurag Agrawal; Partha Rakshit

doi:10.1126/science.abj9932

Genomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, India

Mahesh S. Dhar, Robin Marwal, V. S. Radhakrishnan, Kalaiarasan Ponnusamy, Bani Jolly, Rahul C. Bhoyar, Viren Sardana, Salwa Naushin, Mercy Rophina, Thomas A. Mellan, Swapnil Mishra, Charles Whittaker, Saman Fatihi, Meena Datta, Priyanka Singh, Uma Sharma, Rajat Ujjainiya, Nitin Bhatheja, Mohit Kumar Divakar, Manoj K. SinghMohamed Imran, Vigneshwar Senthivel, Ranjeet Maurya, Neha Jha, Priyanka Mehta, A. Vivekanand, Pooja Sharma, V. R. Arvinden, Urmila Chaudhary, Namita Soni, Lipi Thukral, Seth Flaxman, Samir Bhatt, Rajesh Pandey, Debasis Dash, Mohammed Faruq, Hemlata Lall, Hema Gogia, Preeti Madan, Sanket Kulkarni, Himanshu Chauhan, Shantanu Sengupta, Sandhya Kabra, Ravindra K. Gupta, Sujeet K. Singh, Anurag Agrawal, Partha Rakshit^*

^*Corresponding author af dette arbejde

Afdeling for Epidemiologi

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

179 Citationer (Scopus)

12 Downloads (Pure)

Abstract

Delhi, the national capital of India, experienced multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreaks in 2020 and reached population seropositivity of >50% by 2021. During April 2021, the city became overwhelmed by COVID-19 cases and fatalities, as a new variant, B.1.617.2 (Delta), replaced B.1.1.7 (Alpha). A Bayesian model explains the growth advantage of Delta through a combination of increased transmissibility and reduced sensitivity to immune responses generated against earlier variants (median estimates: 1.5-fold greater transmissibility and 20% reduction in sensitivity). Seropositivity of an employee and family cohort increased from 42% to 87.5% between March and July 2021, with 27% reinfections, as judged by increased antibody concentration after a previous decline. The likely high transmissibility and partial evasion of immunity by the Delta variant contributed to an overwhelming surge in Delhi.

Originalsprog	Engelsk
Tidsskrift	Science
Vol/bind	374
Udgave nummer	6570
Sider (fra-til)	995-999
Antal sider	5
ISSN	0036-8075
DOI	https://doi.org/10.1126/science.abj9932
Status	Udgivet - 2021

Bibliografisk note

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© 2021 American Association for the Advancement of Science. All rights reserved.

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10.1126/science.abj9932Licens: CC BY

FulltextForlagets udgivne version, 11,3 MBLicens: CC BY

Citationsformater

Dhar, M. S., Marwal, R., Radhakrishnan, V. S., Ponnusamy, K., Jolly, B., Bhoyar, R. C., Sardana, V., Naushin, S., Rophina, M., Mellan, T. A., Mishra, S., Whittaker, C., Fatihi, S., Datta, M., Singh, P., Sharma, U., Ujjainiya, R., Bhatheja, N., Divakar, M. K., ... Rakshit, P. (2021). Genomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, India. Science, 374(6570), 995-999. https://doi.org/10.1126/science.abj9932

Dhar, MS, Marwal, R, Radhakrishnan, VS, Ponnusamy, K, Jolly, B, Bhoyar, RC, Sardana, V, Naushin, S, Rophina, M, Mellan, TA, Mishra, S, Whittaker, C, Fatihi, S, Datta, M, Singh, P, Sharma, U, Ujjainiya, R, Bhatheja, N, Divakar, MK, Singh, MK, Imran, M, Senthivel, V, Maurya, R, Jha, N, Mehta, P, Vivekanand, A, Sharma, P, Arvinden, VR, Chaudhary, U, Soni, N, Thukral, L, Flaxman, S, Bhatt, S, Pandey, R, Dash, D, Faruq, M, Lall, H, Gogia, H, Madan, P, Kulkarni, S, Chauhan, H, Sengupta, S, Kabra, S, Gupta, RK, Singh, SK, Agrawal, A & Rakshit, P 2021, 'Genomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, India', Science, bind 374, nr. 6570, s. 995-999. https://doi.org/10.1126/science.abj9932

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title = "Genomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, India",

abstract = "Delhi, the national capital of India, experienced multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreaks in 2020 and reached population seropositivity of >50% by 2021. During April 2021, the city became overwhelmed by COVID-19 cases and fatalities, as a new variant, B.1.617.2 (Delta), replaced B.1.1.7 (Alpha). A Bayesian model explains the growth advantage of Delta through a combination of increased transmissibility and reduced sensitivity to immune responses generated against earlier variants (median estimates: 1.5-fold greater transmissibility and 20% reduction in sensitivity). Seropositivity of an employee and family cohort increased from 42% to 87.5% between March and July 2021, with 27% reinfections, as judged by increased antibody concentration after a previous decline. The likely high transmissibility and partial evasion of immunity by the Delta variant contributed to an overwhelming surge in Delhi.",

author = "Dhar, {Mahesh S.} and Robin Marwal and Radhakrishnan, {V. S.} and Kalaiarasan Ponnusamy and Bani Jolly and Bhoyar, {Rahul C.} and Viren Sardana and Salwa Naushin and Mercy Rophina and Mellan, {Thomas A.} and Swapnil Mishra and Charles Whittaker and Saman Fatihi and Meena Datta and Priyanka Singh and Uma Sharma and Rajat Ujjainiya and Nitin Bhatheja and Divakar, {Mohit Kumar} and Singh, {Manoj K.} and Mohamed Imran and Vigneshwar Senthivel and Ranjeet Maurya and Neha Jha and Priyanka Mehta and A. Vivekanand and Pooja Sharma and Arvinden, {V. R.} and Urmila Chaudhary and Namita Soni and Lipi Thukral and Seth Flaxman and Samir Bhatt and Rajesh Pandey and Debasis Dash and Mohammed Faruq and Hemlata Lall and Hema Gogia and Preeti Madan and Sanket Kulkarni and Himanshu Chauhan and Shantanu Sengupta and Sandhya Kabra and Gupta, {Ravindra K.} and Singh, {Sujeet K.} and Anurag Agrawal and Partha Rakshit",

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AU - Dhar, Mahesh S.

AU - Marwal, Robin

AU - Radhakrishnan, V. S.

AU - Ponnusamy, Kalaiarasan

AU - Jolly, Bani

AU - Bhoyar, Rahul C.

AU - Sardana, Viren

AU - Naushin, Salwa

AU - Rophina, Mercy

AU - Mellan, Thomas A.

AU - Mishra, Swapnil

AU - Whittaker, Charles

AU - Fatihi, Saman

AU - Datta, Meena

AU - Singh, Priyanka

AU - Sharma, Uma

AU - Ujjainiya, Rajat

AU - Bhatheja, Nitin

AU - Divakar, Mohit Kumar

AU - Singh, Manoj K.

AU - Imran, Mohamed

AU - Senthivel, Vigneshwar

AU - Maurya, Ranjeet

AU - Jha, Neha

AU - Mehta, Priyanka

AU - Vivekanand, A.

AU - Sharma, Pooja

AU - Arvinden, V. R.

AU - Chaudhary, Urmila

AU - Soni, Namita

AU - Thukral, Lipi

AU - Flaxman, Seth

AU - Bhatt, Samir

AU - Pandey, Rajesh

AU - Dash, Debasis

AU - Faruq, Mohammed

AU - Lall, Hemlata

AU - Gogia, Hema

AU - Madan, Preeti

AU - Kulkarni, Sanket

AU - Chauhan, Himanshu

AU - Sengupta, Shantanu

AU - Kabra, Sandhya

AU - Gupta, Ravindra K.

AU - Singh, Sujeet K.

AU - Agrawal, Anurag

AU - Rakshit, Partha

PY - 2021

Y1 - 2021

N2 - Delhi, the national capital of India, experienced multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreaks in 2020 and reached population seropositivity of >50% by 2021. During April 2021, the city became overwhelmed by COVID-19 cases and fatalities, as a new variant, B.1.617.2 (Delta), replaced B.1.1.7 (Alpha). A Bayesian model explains the growth advantage of Delta through a combination of increased transmissibility and reduced sensitivity to immune responses generated against earlier variants (median estimates: 1.5-fold greater transmissibility and 20% reduction in sensitivity). Seropositivity of an employee and family cohort increased from 42% to 87.5% between March and July 2021, with 27% reinfections, as judged by increased antibody concentration after a previous decline. The likely high transmissibility and partial evasion of immunity by the Delta variant contributed to an overwhelming surge in Delhi.

AB - Delhi, the national capital of India, experienced multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreaks in 2020 and reached population seropositivity of >50% by 2021. During April 2021, the city became overwhelmed by COVID-19 cases and fatalities, as a new variant, B.1.617.2 (Delta), replaced B.1.1.7 (Alpha). A Bayesian model explains the growth advantage of Delta through a combination of increased transmissibility and reduced sensitivity to immune responses generated against earlier variants (median estimates: 1.5-fold greater transmissibility and 20% reduction in sensitivity). Seropositivity of an employee and family cohort increased from 42% to 87.5% between March and July 2021, with 27% reinfections, as judged by increased antibody concentration after a previous decline. The likely high transmissibility and partial evasion of immunity by the Delta variant contributed to an overwhelming surge in Delhi.

U2 - 10.1126/science.abj9932

DO - 10.1126/science.abj9932

M3 - Journal article

C2 - 34648303

AN - SCOPUS:85118619545

SN - 0036-8075

VL - 374

SP - 995

EP - 999

JO - Science

JF - Science

IS - 6570

ER -