Gestational Hypertension and High-Density Lipoprotein Function: An Explorative Study in Overweight/Obese Women of the DALI Cohort

Julia T. Stadler; M. N. M. van Poppel; Christina Christoffersen; David Hill; Christian Wadsack; David Simmons; Gernot Desoye; Gunther Marsche; null DALI Core Investigator Grp

doi:10.3390/antiox12010068

Gestational Hypertension and High-Density Lipoprotein Function: An Explorative Study in Overweight/Obese Women of the DALI Cohort

Julia T. Stadler, M. N. M. van Poppel, Christina Christoffersen, David Hill, Christian Wadsack, David Simmons, Gernot Desoye, Gunther Marsche, DALI Core Investigator Grp

Physiology of circulation, kidney and lung

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

10 Citationer (Scopus)

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Abstract

Gestational hypertension (GHTN) is associated with an increased cardiovascular risk for mothers and their offspring later in life. High-density lipoproteins (HDL) are anti-atherogenic by promoting efflux of cholesterol from macrophages and suppression of endothelial cell activation. Functional impairment of HDL in GHTN-complicated pregnancies may affect long-term health of both mothers and offspring. We studied functional parameters of maternal and neonatal HDL in 192 obese women (pre-pregnancy BMI >= 29), who were at high risk for GHTN. Maternal blood samples were collected longitudinally at

Originalsprog	Engelsk
Artikelnummer	68
Tidsskrift	Antioxidants
Vol/bind	12
Udgave nummer	1
Antal sider	13
ISSN	2076-3921
DOI	https://doi.org/10.3390/antiox12010068
Status	Udgivet - 2023

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10.3390/antiox12010068Licens: CC BY

fulltextLicens: CC BY

Citationsformater

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title = "Gestational Hypertension and High-Density Lipoprotein Function: An Explorative Study in Overweight/Obese Women of the DALI Cohort",

abstract = "Gestational hypertension (GHTN) is associated with an increased cardiovascular risk for mothers and their offspring later in life. High-density lipoproteins (HDL) are anti-atherogenic by promoting efflux of cholesterol from macrophages and suppression of endothelial cell activation. Functional impairment of HDL in GHTN-complicated pregnancies may affect long-term health of both mothers and offspring. We studied functional parameters of maternal and neonatal HDL in 192 obese women (pre-pregnancy BMI >= 29), who were at high risk for GHTN. Maternal blood samples were collected longitudinally at",

keywords = "gestational hypertension, HDL, cholesterol efflux capacity, paraoxonase-1, apolipoprotein M, pregnancy, obesity, APOLIPOPROTEIN-M, CARDIOVASCULAR-DISEASE, CHOLESTEROL EFFLUX, PREECLAMPSIA, PREGNANCY, PROTEIN, RISK, POLYMORPHISMS, CAPACITY",

author = "Stadler, {Julia T.} and {van Poppel}, {M. N. M.} and Christina Christoffersen and David Hill and Christian Wadsack and David Simmons and Gernot Desoye and Gunther Marsche and {DALI Core Investigator Grp}",

year = "2023",

doi = "10.3390/antiox12010068",

language = "English",

volume = "12",

journal = "Antioxidants",

issn = "2076-3921",

publisher = "M D P I AG",

number = "1",

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TY - JOUR

T1 - Gestational Hypertension and High-Density Lipoprotein Function

T2 - An Explorative Study in Overweight/Obese Women of the DALI Cohort

AU - Stadler, Julia T.

AU - van Poppel, M. N. M.

AU - Christoffersen, Christina

AU - Hill, David

AU - Wadsack, Christian

AU - Simmons, David

AU - Desoye, Gernot

AU - Marsche, Gunther

AU - DALI Core Investigator Grp, null

PY - 2023

Y1 - 2023

N2 - Gestational hypertension (GHTN) is associated with an increased cardiovascular risk for mothers and their offspring later in life. High-density lipoproteins (HDL) are anti-atherogenic by promoting efflux of cholesterol from macrophages and suppression of endothelial cell activation. Functional impairment of HDL in GHTN-complicated pregnancies may affect long-term health of both mothers and offspring. We studied functional parameters of maternal and neonatal HDL in 192 obese women (pre-pregnancy BMI >= 29), who were at high risk for GHTN. Maternal blood samples were collected longitudinally at

AB - Gestational hypertension (GHTN) is associated with an increased cardiovascular risk for mothers and their offspring later in life. High-density lipoproteins (HDL) are anti-atherogenic by promoting efflux of cholesterol from macrophages and suppression of endothelial cell activation. Functional impairment of HDL in GHTN-complicated pregnancies may affect long-term health of both mothers and offspring. We studied functional parameters of maternal and neonatal HDL in 192 obese women (pre-pregnancy BMI >= 29), who were at high risk for GHTN. Maternal blood samples were collected longitudinally at

KW - gestational hypertension

KW - HDL

KW - cholesterol efflux capacity

KW - paraoxonase-1

KW - apolipoprotein M

KW - pregnancy

KW - obesity

KW - APOLIPOPROTEIN-M

KW - CARDIOVASCULAR-DISEASE

KW - CHOLESTEROL EFFLUX

KW - PREECLAMPSIA

KW - PREGNANCY

KW - PROTEIN

KW - RISK

KW - POLYMORPHISMS

KW - CAPACITY

U2 - 10.3390/antiox12010068

DO - 10.3390/antiox12010068

M3 - Journal article

C2 - 36670930

SN - 2076-3921

VL - 12

JO - Antioxidants

JF - Antioxidants

IS - 1

M1 - 68

ER -