GH administration and discontinuation in healthy elderly men: effects on body composition, GH-related serum markers, resting heart rate and resting oxygen uptake

K H Lange, F Isaksson, M H Rasmussen, A Juul, J Bülow, M Kjaer

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31 Citationer (Scopus)

Abstract

GH administration results in increased lean body mass (LBM), decreased fat mass (FM) and increased energy expenditure (EE). GH therapy may therefore have potential benefits, especially in the elderly, who are known to have decreased function of the GH/IGF-I axis. Several studies have focused on effects of GH administration in the elderly in the last decade. However, very limited information is available regarding changes in body composition and EE upon GH discontinuation in the elderly. The present study therefore investigated the effects of 12 weeks of GH administration and subsequent discontinuation on body composition, resting oxygen uptake (VO2), resting heart rate (HR) and GH related serum markers in healthy elderly men.
OriginalsprogEngelsk
TidsskriftClinical Endocrinology
Vol/bind55
Udgave nummer1
Sider (fra-til)77-86
Antal sider10
ISSN0300-0664
StatusUdgivet - 2001

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