Global priorities for large-scale biomarker-based prospective cohorts

Rory Collins; Mary K. Balaconis; Søren Brunak; Zhengming Chen; Mary De Silva; J. Michael Gaziano; Geoffrey S. Ginsburg; Prabhat Jha; Pablo Kuri; Andres Metspalu; Nicola Mulder; Neil Risch

doi:10.1016/j.xgen.2022.100141

Global priorities for large-scale biomarker-based prospective cohorts

Rory Collins^*, Mary K. Balaconis, Søren Brunak, Zhengming Chen, Mary De Silva, J. Michael Gaziano, Geoffrey S. Ginsburg, Prabhat Jha, Pablo Kuri, Andres Metspalu, Nicola Mulder, Neil Risch

^*Corresponding author af dette arbejde

Brunak Group

Publikation: Bidrag til tidsskrift › Kommentar/debat › Forskning

6 Citationer (Scopus)

13 Downloads (Pure)

Abstract

The focus of this paper is on strategic approaches for establishing population-based prospective cohorts that collect and store biological samples from very large numbers of participants to help identify the determinants of common health outcomes. In particular, it aims to address key issues related to investigation of genetic, as well as social, environmental, and ancestral, diversity; generation of detailed genetic and other types of assay data; collection of detailed lifestyle and environmental exposure information; follow-up and characterization of incident health outcomes; and overcoming obstacles to data sharing and access (including capacity building). It concludes that there is a need for strategic planning at an international level (rather than the current ad hoc approach) toward the development of a carefully selected set of deeply characterized large-scale prospective cohorts that are readily accessible by researchers around the world.

Originalsprog	Engelsk
Artikelnummer	100141
Tidsskrift	Cell Genomics
Vol/bind	2
Udgave nummer	6
Antal sider	4
ISSN	2666-979x
DOI	https://doi.org/10.1016/j.xgen.2022.100141
Status	Udgivet - 2022

Bibliografisk note

Funding Information:
This commentary was written by a working group created jointly by the International Common Disease Alliance (ICDA) and the International HundredK+ Cohorts Consortium (IHCC). The conceptualization of this paper derived from a series of discussions among the authors. The first author produced the initial draft and revised the paper in accordance with comments and edits provided by all of the co-authors who approved the final version. R.C. is the principal investigator (PI) and CEO of UK Biobank; Z.C. is the co-PI of the China Kadoorie Biobank; M.G. is the PI of the Million Veteran Program; G.G. is the chief medical and scientific officer of the All of Us Program; P.K. is the director of Proyecto OriGen; A.M. is the head of the Estonian Biobank; and N.M. is on the advisory board of Cell Genomics.

Publisher Copyright:
© 2022 The Author(s)

Adgang til dokumentet

10.1016/j.xgen.2022.100141Licens: CC BY

FulltextForlagets udgivne version, 275 KBLicens: CC BY

Citationsformater

Global priorities for large-scale biomarker-based prospective cohorts. / Collins, Rory; Balaconis, Mary K.; Brunak, Søren; Chen, Zhengming; De Silva, Mary; Gaziano, J. Michael; Ginsburg, Geoffrey S.; Jha, Prabhat; Kuri, Pablo; Metspalu, Andres; Mulder, Nicola; Risch, Neil.

I: Cell Genomics, Bind 2, Nr. 6, 100141, 2022.

Publikation: Bidrag til tidsskrift › Kommentar/debat › Forskning

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