Glucagon like peptide-1-induced glucose metabolism in differentiated human muscle satellite cells is attenuated by hyperglycemia

Charlotte J Green; Tora I Henriksen; Bente K Pedersen; Thomas Solomon

doi:10.1371/journal.pone.0044284

Glucagon like peptide-1-induced glucose metabolism in differentiated human muscle satellite cells is attenuated by hyperglycemia

Charlotte J Green
, Tora I Henriksen
, Bente K Pedersen
, Thomas Solomon

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Abstract

Glucagon like peptide-1 (GLP-1) stimulates insulin secretion from the pancreas but also has extra-pancreatic effects. GLP-1 may stimulate glucose uptake in cultured muscle cells but the mechanism is not clearly defined. Furthermore, while the pancreatic effects of GLP-1 are glucose-dependent, the glucose-dependency of its extra-pancreatic effects has not been examined.

Originalsprog	Engelsk
Tidsskrift	P L o S One
Vol/bind	7
Udgave nummer	8
Sider (fra-til)	e44284
ISSN	1932-6203
DOI	https://doi.org/10.1371/journal.pone.0044284
Status	Udgivet - 2012

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10.1371/journal.pone.0044284

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Citationsformater

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title = "Glucagon like peptide-1-induced glucose metabolism in differentiated human muscle satellite cells is attenuated by hyperglycemia",

abstract = "Glucagon like peptide-1 (GLP-1) stimulates insulin secretion from the pancreas but also has extra-pancreatic effects. GLP-1 may stimulate glucose uptake in cultured muscle cells but the mechanism is not clearly defined. Furthermore, while the pancreatic effects of GLP-1 are glucose-dependent, the glucose-dependency of its extra-pancreatic effects has not been examined.",

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AU - Green, Charlotte J

AU - Henriksen, Tora I

AU - Pedersen, Bente K

AU - Solomon, Thomas

PY - 2012

Y1 - 2012

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AB - Glucagon like peptide-1 (GLP-1) stimulates insulin secretion from the pancreas but also has extra-pancreatic effects. GLP-1 may stimulate glucose uptake in cultured muscle cells but the mechanism is not clearly defined. Furthermore, while the pancreatic effects of GLP-1 are glucose-dependent, the glucose-dependency of its extra-pancreatic effects has not been examined.

KW - Cell Differentiation

KW - Cell Proliferation

KW - Cells, Cultured

KW - Glucagon-Like Peptide 1

KW - Glucose

KW - Glycogen

KW - Humans

KW - Hyperglycemia

KW - Insulin

KW - Male

KW - Receptors, Glucagon

KW - Satellite Cells, Skeletal Muscle

KW - Signal Transduction

KW - Young Adult

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DO - 10.1371/journal.pone.0044284

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SP - e44284

JO - P L o S One

JF - P L o S One

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ER -