Abstract
G-protein-coupled receptors (GPCRs) are important drug targets with chemically diverse ligands and varying intracellular coupling partners. Recent work by Laboute et al. deorphanized GPR158 as a metabotropic glycine receptor (mGlyR), thereby providing evidence of a novel neuromodulatory system involving this non-canonical Class C receptor with an impact on cognition and affective states.
Originalsprog | Engelsk |
---|---|
Tidsskrift | Trends in Pharmacological Sciences |
Vol/bind | 44 |
Udgave nummer | 8 |
Sider (fra-til) | 489-491 |
ISSN | 0165-6147 |
DOI | |
Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:The authors would like to thank Felix Faas for help with the figure. This work was supported by R01 NS122394 (J.M.M.), the Kirsten and Freddy Johansens Foundation , 2017-112697 (M.M.R.), The Lundbeck Foundation , R268-2017-409 (M.M.R.), and The Lundbeck Foundation Experiment R346-2020-1829 (J.M.M.).
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