Glycine: a long-sought novel ligand for GPR158

Mette Marie Rosenkilde; Jesper Mosolff Mathiesen

doi:10.1016/j.tips.2023.05.004

Glycine: a long-sought novel ligand for GPR158

Mette Marie Rosenkilde^*, Jesper Mosolff Mathiesen

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Letter › peer review

1 Citationer (Scopus)

35 Downloads (Pure)

Abstract

G-protein-coupled receptors (GPCRs) are important drug targets with chemically diverse ligands and varying intracellular coupling partners. Recent work by Laboute et al. deorphanized GPR158 as a metabotropic glycine receptor (mGlyR), thereby providing evidence of a novel neuromodulatory system involving this non-canonical Class C receptor with an impact on cognition and affective states.

Originalsprog	Engelsk
Tidsskrift	Trends in Pharmacological Sciences
Vol/bind	44
Udgave nummer	8
Sider (fra-til)	489-491
ISSN	0165-6147
DOI	https://doi.org/10.1016/j.tips.2023.05.004
Status	Udgivet - 2023

Bibliografisk note

Funding Information:
The authors would like to thank Felix Faas for help with the figure. This work was supported by R01 NS122394 (J.M.M.), the Kirsten and Freddy Johansens Foundation , 2017-112697 (M.M.R.), The Lundbeck Foundation , R268-2017-409 (M.M.R.), and The Lundbeck Foundation Experiment R346-2020-1829 (J.M.M.).

Publisher Copyright:
© 2023 Elsevier Ltd

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10.1016/j.tips.2023.05.004

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Citationsformater

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title = "Glycine: a long-sought novel ligand for GPR158",

abstract = "G-protein-coupled receptors (GPCRs) are important drug targets with chemically diverse ligands and varying intracellular coupling partners. Recent work by Laboute et al. deorphanized GPR158 as a metabotropic glycine receptor (mGlyR), thereby providing evidence of a novel neuromodulatory system involving this non-canonical Class C receptor with an impact on cognition and affective states.",

keywords = "class C GPCRs, glycine, GPR158, metabotropic receptor",

author = "Rosenkilde, {Mette Marie} and Mathiesen, {Jesper Mosolff}",

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year = "2023",

doi = "10.1016/j.tips.2023.05.004",

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T2 - a long-sought novel ligand for GPR158

AU - Rosenkilde, Mette Marie

AU - Mathiesen, Jesper Mosolff

PY - 2023

Y1 - 2023

N2 - G-protein-coupled receptors (GPCRs) are important drug targets with chemically diverse ligands and varying intracellular coupling partners. Recent work by Laboute et al. deorphanized GPR158 as a metabotropic glycine receptor (mGlyR), thereby providing evidence of a novel neuromodulatory system involving this non-canonical Class C receptor with an impact on cognition and affective states.

AB - G-protein-coupled receptors (GPCRs) are important drug targets with chemically diverse ligands and varying intracellular coupling partners. Recent work by Laboute et al. deorphanized GPR158 as a metabotropic glycine receptor (mGlyR), thereby providing evidence of a novel neuromodulatory system involving this non-canonical Class C receptor with an impact on cognition and affective states.

KW - class C GPCRs

KW - glycine

KW - GPR158

KW - metabotropic receptor

U2 - 10.1016/j.tips.2023.05.004

DO - 10.1016/j.tips.2023.05.004

M3 - Letter

C2 - 37321907

AN - SCOPUS:85162846179

SN - 0165-6147

VL - 44

SP - 489

EP - 491

JO - Trends in Pharmacological Sciences

JF - Trends in Pharmacological Sciences

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ER -