High glucose impairs superoxide production from isolated blood neutrophils

A Perner; S E Nielsen; J Rask-Madsen

doi:10.1007/s00134-002-1628-4

High glucose impairs superoxide production from isolated blood neutrophils

A Perner, S E Nielsen, J Rask-Madsen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

148 Citationer (Scopus)

Abstract

Superoxide (O(2)(-)), a key antimicrobial agent in phagocytes, is produced by the activity of NADPH oxidase. High glucose concentrations may, however, impair the production of O(2)(-) through inhibition of glucose-6-phosphate dehydrogenase (G6PD), which catalyzes the formation of NADPH. This study measured the acute effects of high glucose or the G6PD inhibitor dehydroepiandrosterone (DHEA) on the production of O(2)(-) from isolated human neutrophils.

Originalsprog	Engelsk
Tidsskrift	Intensive Care Medicine
Vol/bind	29
Udgave nummer	4
Sider (fra-til)	642-5
Antal sider	4
ISSN	0342-4642
DOI	https://doi.org/10.1007/s00134-002-1628-4
Status	Udgivet - apr. 2003

Adgang til dokumentet

10.1007/s00134-002-1628-4

Citationsformater

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title = "High glucose impairs superoxide production from isolated blood neutrophils",

abstract = "Superoxide (O(2)(-)), a key antimicrobial agent in phagocytes, is produced by the activity of NADPH oxidase. High glucose concentrations may, however, impair the production of O(2)(-) through inhibition of glucose-6-phosphate dehydrogenase (G6PD), which catalyzes the formation of NADPH. This study measured the acute effects of high glucose or the G6PD inhibitor dehydroepiandrosterone (DHEA) on the production of O(2)(-) from isolated human neutrophils.",

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T1 - High glucose impairs superoxide production from isolated blood neutrophils

AU - Perner, A

AU - Nielsen, S E

AU - Rask-Madsen, J

PY - 2003/4

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N2 - Superoxide (O(2)(-)), a key antimicrobial agent in phagocytes, is produced by the activity of NADPH oxidase. High glucose concentrations may, however, impair the production of O(2)(-) through inhibition of glucose-6-phosphate dehydrogenase (G6PD), which catalyzes the formation of NADPH. This study measured the acute effects of high glucose or the G6PD inhibitor dehydroepiandrosterone (DHEA) on the production of O(2)(-) from isolated human neutrophils.

AB - Superoxide (O(2)(-)), a key antimicrobial agent in phagocytes, is produced by the activity of NADPH oxidase. High glucose concentrations may, however, impair the production of O(2)(-) through inhibition of glucose-6-phosphate dehydrogenase (G6PD), which catalyzes the formation of NADPH. This study measured the acute effects of high glucose or the G6PD inhibitor dehydroepiandrosterone (DHEA) on the production of O(2)(-) from isolated human neutrophils.

U2 - 10.1007/s00134-002-1628-4

DO - 10.1007/s00134-002-1628-4

M3 - Journal article

SN - 0342-4642

VL - 29

SP - 642

EP - 645

JO - Intensive Care Medicine

JF - Intensive Care Medicine

IS - 4

ER -