High level of male-biased Scandinavian admixture in Greenlandic Inuit shown by Y-chromosomal analysis

Elena Bosch; Francesc Calafell; Zoë H Rosser; Søren Nørby; Niels Lynnerup; Matthew E Hurles; Mark A Jobling

doi:10.1007/s00439-003-0913-9

High level of male-biased Scandinavian admixture in Greenlandic Inuit shown by Y-chromosomal analysis

Elena Bosch, Francesc Calafell, Zoë H Rosser, Søren Nørby, Niels Lynnerup, Matthew E Hurles, Mark A Jobling

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

58 Citationer (Scopus)

Abstract

Udgivelsesdato: 2003-Apr

Originalsprog	Engelsk
Tidsskrift	Human Genetics
Vol/bind	112
Udgave nummer	4
Sider (fra-til)	353-63
Antal sider	11
ISSN	0340-6717
DOI	https://doi.org/10.1007/s00439-003-0913-9
Status	Udgivet - 2003

Bibliografisk note

Keywords: Asian Continental Ancestry Group; Chromosomes, Human, Y; Denmark; European Continental Ancestry Group; Genetic Markers; Greenland; Haplotypes; Humans; Iceland; Inuits; Male; Microsatellite Repeats; Norway

Adgang til dokumentet

10.1007/s00439-003-0913-9

Citationsformater

@article{2dd155f09e4511df928f000ea68e967b,

title = "High level of male-biased Scandinavian admixture in Greenlandic Inuit shown by Y-chromosomal analysis",

abstract = "We have used binary markers and microsatellites on the Y chromosome to analyse diversity in a sample of Greenlandic Inuit males. This sample contains Y chromosomes typical of those found in European populations. Because the Y chromosome has a unique and robust phylogeny of a time depth that precedes the split between European and Native American populations, it is possible to assign chromosomes in an admixed population to either continental source. On this basis, 58+/-6% of these Y chromosomes have been assigned to a European origin. The high proportion of European Y chromosomes contrasts with a complete absence of European mitochondrial DNA and indicates strongly male-biased European admixture into Inuit. Comparison of the European component of Inuit Y chromosomes with European population data suggests that they have their origins in Scandinavia. There are two potential source populations: Norse settlers from Iceland, who may have been assimilated 500 years ago, and the Danish-Norwegian colonists of the eighteenth century. Insufficient differentiation between modern Icelandic and Danish Y chromosomes means that a choice between these cannot be made on the basis of diversity analysis. However, the extreme sex bias in the admixture makes the later event more likely as the source.",

author = "Elena Bosch and Francesc Calafell and Rosser, {Zo{\"e} H} and S{\o}ren N{\o}rby and Niels Lynnerup and Hurles, {Matthew E} and Jobling, {Mark A}",

note = "Keywords: Asian Continental Ancestry Group; Chromosomes, Human, Y; Denmark; European Continental Ancestry Group; Genetic Markers; Greenland; Haplotypes; Humans; Iceland; Inuits; Male; Microsatellite Repeats; Norway",

year = "2003",

doi = "10.1007/s00439-003-0913-9",

language = "English",

volume = "112",

pages = "353--63",

journal = "Human Genetics",

issn = "0340-6717",

publisher = "Springer",

number = "4",

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TY - JOUR

T1 - High level of male-biased Scandinavian admixture in Greenlandic Inuit shown by Y-chromosomal analysis

AU - Bosch, Elena

AU - Calafell, Francesc

AU - Rosser, Zoë H

AU - Nørby, Søren

AU - Lynnerup, Niels

AU - Hurles, Matthew E

AU - Jobling, Mark A

N1 - Keywords: Asian Continental Ancestry Group; Chromosomes, Human, Y; Denmark; European Continental Ancestry Group; Genetic Markers; Greenland; Haplotypes; Humans; Iceland; Inuits; Male; Microsatellite Repeats; Norway

PY - 2003

Y1 - 2003

N2 - We have used binary markers and microsatellites on the Y chromosome to analyse diversity in a sample of Greenlandic Inuit males. This sample contains Y chromosomes typical of those found in European populations. Because the Y chromosome has a unique and robust phylogeny of a time depth that precedes the split between European and Native American populations, it is possible to assign chromosomes in an admixed population to either continental source. On this basis, 58+/-6% of these Y chromosomes have been assigned to a European origin. The high proportion of European Y chromosomes contrasts with a complete absence of European mitochondrial DNA and indicates strongly male-biased European admixture into Inuit. Comparison of the European component of Inuit Y chromosomes with European population data suggests that they have their origins in Scandinavia. There are two potential source populations: Norse settlers from Iceland, who may have been assimilated 500 years ago, and the Danish-Norwegian colonists of the eighteenth century. Insufficient differentiation between modern Icelandic and Danish Y chromosomes means that a choice between these cannot be made on the basis of diversity analysis. However, the extreme sex bias in the admixture makes the later event more likely as the source.

AB - We have used binary markers and microsatellites on the Y chromosome to analyse diversity in a sample of Greenlandic Inuit males. This sample contains Y chromosomes typical of those found in European populations. Because the Y chromosome has a unique and robust phylogeny of a time depth that precedes the split between European and Native American populations, it is possible to assign chromosomes in an admixed population to either continental source. On this basis, 58+/-6% of these Y chromosomes have been assigned to a European origin. The high proportion of European Y chromosomes contrasts with a complete absence of European mitochondrial DNA and indicates strongly male-biased European admixture into Inuit. Comparison of the European component of Inuit Y chromosomes with European population data suggests that they have their origins in Scandinavia. There are two potential source populations: Norse settlers from Iceland, who may have been assimilated 500 years ago, and the Danish-Norwegian colonists of the eighteenth century. Insufficient differentiation between modern Icelandic and Danish Y chromosomes means that a choice between these cannot be made on the basis of diversity analysis. However, the extreme sex bias in the admixture makes the later event more likely as the source.

U2 - 10.1007/s00439-003-0913-9

DO - 10.1007/s00439-003-0913-9

M3 - Journal article

C2 - 12594533

VL - 112

SP - 353

EP - 363

JO - Human Genetics

JF - Human Genetics

SN - 0340-6717

IS - 4

ER -