High levels of soluble VEGF receptor 1 early after trauma are associated with shock, sympathoadrenal activation, glycocalyx degradation and inflammation in severely injured patients: a prospective study

Sisse R Ostrowski; Anne Marie Sørensen; Nis Agerlin Windeløv; Anders Perner; Karen-Lise Welling; Michael Wanscher; Claus F Larsen; Pär I Johansson

doi:10.1186/1757-7241-20-27

High levels of soluble VEGF receptor 1 early after trauma are associated with shock, sympathoadrenal activation, glycocalyx degradation and inflammation in severely injured patients: a prospective study

Sisse R Ostrowski, Anne Marie Sørensen, Nis Agerlin Windeløv, Anders Perner, Karen-Lise Welling, Michael Wanscher, Claus F Larsen, Pär I Johansson

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

51 Citationer (Scopus)

Abstract

The level of soluble vascular endothelial growth factor receptor 1 (sVEGFR1) is increased in sepsis and strongly associated with disease severity and mortality. Endothelial activation and damage contribute to both sepsis and trauma pathology. Therefore, this study measured sVEGFR1 levels in trauma patients upon hospital admission hypothesizing that sVEGFR1 would increase with higher injury severity and predict a poor outcome.

Originalsprog	Engelsk
Tidsskrift	Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Vol/bind	20
Sider (fra-til)	27
ISSN	1757-7241
DOI	https://doi.org/10.1186/1757-7241-20-27
Status	Udgivet - 2012

Adgang til dokumentet

10.1186/1757-7241-20-27

Citationsformater

Ostrowski, S. R., Sørensen, A. M., Windeløv, N. A., Perner, A., Welling, K-L., Wanscher, M., Larsen, C. F., & Johansson, P. I. (2012). High levels of soluble VEGF receptor 1 early after trauma are associated with shock, sympathoadrenal activation, glycocalyx degradation and inflammation in severely injured patients: a prospective study. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 20, 27. https://doi.org/10.1186/1757-7241-20-27

High levels of soluble VEGF receptor 1 early after trauma are associated with shock, sympathoadrenal activation, glycocalyx degradation and inflammation in severely injured patients : a prospective study. / Ostrowski, Sisse R; Sørensen, Anne Marie; Windeløv, Nis Agerlin; Perner, Anders; Welling, Karen-Lise; Wanscher, Michael; Larsen, Claus F; Johansson, Pär I.

I: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, Bind 20, 2012, s. 27.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Ostrowski, SR, Sørensen, AM, Windeløv, NA, Perner, A, Welling, K-L, Wanscher, M, Larsen, CF & Johansson, PI 2012, 'High levels of soluble VEGF receptor 1 early after trauma are associated with shock, sympathoadrenal activation, glycocalyx degradation and inflammation in severely injured patients: a prospective study', Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, bind 20, s. 27. https://doi.org/10.1186/1757-7241-20-27

Ostrowski SR, Sørensen AM, Windeløv NA, Perner A, Welling K-L, Wanscher M et al. High levels of soluble VEGF receptor 1 early after trauma are associated with shock, sympathoadrenal activation, glycocalyx degradation and inflammation in severely injured patients: a prospective study. Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine. 2012;20:27. https://doi.org/10.1186/1757-7241-20-27

Ostrowski, Sisse R ; Sørensen, Anne Marie ; Windeløv, Nis Agerlin ; Perner, Anders ; Welling, Karen-Lise ; Wanscher, Michael ; Larsen, Claus F ; Johansson, Pär I. / High levels of soluble VEGF receptor 1 early after trauma are associated with shock, sympathoadrenal activation, glycocalyx degradation and inflammation in severely injured patients : a prospective study. I: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine. 2012 ; Bind 20. s. 27.

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abstract = "The level of soluble vascular endothelial growth factor receptor 1 (sVEGFR1) is increased in sepsis and strongly associated with disease severity and mortality. Endothelial activation and damage contribute to both sepsis and trauma pathology. Therefore, this study measured sVEGFR1 levels in trauma patients upon hospital admission hypothesizing that sVEGFR1 would increase with higher injury severity and predict a poor outcome.",

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AU - Ostrowski, Sisse R

AU - Sørensen, Anne Marie

AU - Windeløv, Nis Agerlin

AU - Perner, Anders

AU - Welling, Karen-Lise

AU - Wanscher, Michael

AU - Larsen, Claus F

AU - Johansson, Pär I

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AB - The level of soluble vascular endothelial growth factor receptor 1 (sVEGFR1) is increased in sepsis and strongly associated with disease severity and mortality. Endothelial activation and damage contribute to both sepsis and trauma pathology. Therefore, this study measured sVEGFR1 levels in trauma patients upon hospital admission hypothesizing that sVEGFR1 would increase with higher injury severity and predict a poor outcome.

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DO - 10.1186/1757-7241-20-27

M3 - Journal article

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