@article{d6dcef50a91e11debc73000ea68e967b,
title = "High-risk human papillomavirus E7 expression reduces cell-surface MHC class I molecules and increases susceptibility to natural killer cells",
abstract = "High-risk human papillomavirus (HPV) is a major causative agent of cervical cancer and the E6 and E7 genes encode the major HPV oncoproteins. The E7 protein from high-risk HPV types alters cell cycle progression and represses genes encoding components of the antigen-presentation pathway, suggesting a role for E7 in tumour immune evasion. We show that knockdown of E7 expression in HPV16- and HPV18-transformed cervical carcinoma cells by RNA interference increased expression of major histocompatibility complex (MHC) class I at the cell surface and reduced susceptibility of these cells to natural killer (NK) cells. Tetracycline-regulated induction of HPV16 E7 resulted in reduced expression of cell surface MHC class I molecules and increased NK cell killing. Our results suggest that, for HPV-associated malignancies, reduced MHC class I expression is the result of an active immune evasion strategy that has evolved to assist viral replication.",
author = "G Bottley and Watherston, {O G} and Y-L Hiew and B Norrild and Cook, {G P} and Blair, {G E}",
note = "Keywords: Cells, Cultured; Female; Hela Cells; Histocompatibility Antigens Class I; Human papillomavirus 16; Human papillomavirus 18; Humans; Killer Cells, Natural; Oncogene Proteins, Viral; Papillomavirus Infections; Tumor Escape; Uterine Cervical Neoplasms",
year = "2007",
doi = "10.1038/sj.onc.1210798",
language = "English",
volume = "27",
pages = "1794--9",
journal = "Oncogene",
issn = "0950-9232",
publisher = "nature publishing group",
number = "12",
}