Abstract
Body weight and adiposity represent biologically controlled parameters that are influenced by a combination of genetic, developmental and environmental variables. Although the hypothalamus plays a crucial role in matching caloric intake with energy expenditure to achieve a stable body weight, it is now recognized that neuronal circuits in the hindbrain not only serve to produce nausea and to terminate feeding in response to food consumption or during pathological states, but also contribute to the long-term control of body weight. Additionally, recent work has identified hindbrain neurons that are capable of suppressing food intake without producing aversive responses like those associated with nausea. Here we review recent advances in our understanding of the hindbrain neurons that control feeding, particularly those located in the area postrema and the nucleus tractus solitarius. We frame this information in the context of new atlases of hindbrain neuronal populations and develop a model of the hindbrain circuits that control food intake and energy balance, suggesting important areas for additional research.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Nature Metabolism |
| Vol/bind | 4 |
| Udgave nummer | 7 |
| Sider (fra-til) | 826-835 |
| Antal sider | 10 |
| ISSN | 2522-5812 |
| DOI | |
| Status | Udgivet - 2022 |
Bibliografisk note
Funding Information:The Banbury conference on Integrated Control of Feeding and Energy Balance by Hypothalamic and Hindbrain Circuits stimulated much of the thinking underlying this article and related work, and we thank R. Leshan, L. Heisler and the attendees of the conference for sharing their thoughts. We also thank C. Rhodes, D. Sandoval and D. Olson and members of their laboratories, along with members of the laboratories of R.J.S., T.H.P. and M.G.M. for helpful discussions. Supported by AstraZeneca, National Institutes of Health (grant P01 DK117821), the American Diabetes Association (1-16-PDF-021 to W.C.), the Lundbeck Foundation (grant no. R190-2014-3904 to T.H.P.), the Novo Nordisk Foundation (grant no. NNF18CC0034900 to the Novo Nordisk Foundation Center for Basic Metabolic Research, which is an independent research centre, based at the University of Copenhagen), and the Danish Diabetes Academy, which is funded by the Novo Nordisk Foundation (grant no. NNF17SA0031406).
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© 2022, Springer Nature Limited.