Histologic features of the portal plate in extrahepatic biliary atresia and their impact on prognosis--a Danish study

Qazaz Mirza; Nina Kvist; Bodil Laub Petersen

doi:10.1016/j.jpedsurg.2008.11.054

Histologic features of the portal plate in extrahepatic biliary atresia and their impact on prognosis--a Danish study

Qazaz Mirza, Nina Kvist, Bodil Laub Petersen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

21 Citationer (Scopus)

Abstract

Udgivelsesdato: 2009-Jul

Originalsprog	Engelsk
Tidsskrift	Journal of Pediatric Surgery
Vol/bind	44
Udgave nummer	7
Sider (fra-til)	1344-8
Antal sider	4
ISSN	0022-3468
DOI	https://doi.org/10.1016/j.jpedsurg.2008.11.054
Status	Udgivet - 2009

Bibliografisk note

Keywords: Bile Ducts, Extrahepatic; Biliary Atresia; Cause of Death; Cell Proliferation; Child; Denmark; Diagnosis, Differential; Humans; Immunohistochemistry; Incidence; Portal System; Portoenterostomy, Hepatic; Prognosis; Retrospective Studies; Survival Rate

Adgang til dokumentet

10.1016/j.jpedsurg.2008.11.054

Citationsformater

@article{0d7e42706a3a11df928f000ea68e967b,

title = "Histologic features of the portal plate in extrahepatic biliary atresia and their impact on prognosis--a Danish study",

abstract = "BACKGROUND/PURPOSE: The aims of this study are as follows: METHOD: From 1979 to 2003, 57 children have been operated by the Kasai procedure. Only 40 of these have had their portal plate removed for histologic examination. We divided the patients according to clinical outcome into a successful and a failure group and compared the histologic features of the portal plates in the 2 groups. Afterward, the portal plate histology from EHBA was compared with the porta hepatis area from patients dead from other causes. RESULTS: A significant difference between the success and the failure group was found with regard to the number of bile ducts, the maximal length measurable in any direction for bile duct structures, and the proliferation, but not for any type of diameter. The normal portal plate was different from the portal plate of children with biliary atresia by always having 2 large biliary structures and the cells being mucinous and columnar in the largest bile ducts. Only 1 of 4 normal portal plates showed signs of proliferation. There was no significant difference between the normal and the success group with respect to the number, maximal length, and proliferation of the bile ducts. A difference in the diameter between the normal group and the entire EHBA group was significant for the maximal internal diameter but not for the other types of diameter measurements. CONCLUSION: The present study shows the following:",

author = "Qazaz Mirza and Nina Kvist and Petersen, {Bodil Laub}",

note = "Keywords: Bile Ducts, Extrahepatic; Biliary Atresia; Cause of Death; Cell Proliferation; Child; Denmark; Diagnosis, Differential; Humans; Immunohistochemistry; Incidence; Portal System; Portoenterostomy, Hepatic; Prognosis; Retrospective Studies; Survival Rate",

year = "2009",

doi = "10.1016/j.jpedsurg.2008.11.054",

language = "English",

volume = "44",

pages = "1344--8",

journal = "Journal of Pediatric Surgery",

issn = "0022-3468",

publisher = "W.B.Saunders Co.",

number = "7",

}

TY - JOUR

T1 - Histologic features of the portal plate in extrahepatic biliary atresia and their impact on prognosis--a Danish study

AU - Mirza, Qazaz

AU - Kvist, Nina

AU - Petersen, Bodil Laub

N1 - Keywords: Bile Ducts, Extrahepatic; Biliary Atresia; Cause of Death; Cell Proliferation; Child; Denmark; Diagnosis, Differential; Humans; Immunohistochemistry; Incidence; Portal System; Portoenterostomy, Hepatic; Prognosis; Retrospective Studies; Survival Rate

PY - 2009

Y1 - 2009

N2 - BACKGROUND/PURPOSE: The aims of this study are as follows: METHOD: From 1979 to 2003, 57 children have been operated by the Kasai procedure. Only 40 of these have had their portal plate removed for histologic examination. We divided the patients according to clinical outcome into a successful and a failure group and compared the histologic features of the portal plates in the 2 groups. Afterward, the portal plate histology from EHBA was compared with the porta hepatis area from patients dead from other causes. RESULTS: A significant difference between the success and the failure group was found with regard to the number of bile ducts, the maximal length measurable in any direction for bile duct structures, and the proliferation, but not for any type of diameter. The normal portal plate was different from the portal plate of children with biliary atresia by always having 2 large biliary structures and the cells being mucinous and columnar in the largest bile ducts. Only 1 of 4 normal portal plates showed signs of proliferation. There was no significant difference between the normal and the success group with respect to the number, maximal length, and proliferation of the bile ducts. A difference in the diameter between the normal group and the entire EHBA group was significant for the maximal internal diameter but not for the other types of diameter measurements. CONCLUSION: The present study shows the following:

AB - BACKGROUND/PURPOSE: The aims of this study are as follows: METHOD: From 1979 to 2003, 57 children have been operated by the Kasai procedure. Only 40 of these have had their portal plate removed for histologic examination. We divided the patients according to clinical outcome into a successful and a failure group and compared the histologic features of the portal plates in the 2 groups. Afterward, the portal plate histology from EHBA was compared with the porta hepatis area from patients dead from other causes. RESULTS: A significant difference between the success and the failure group was found with regard to the number of bile ducts, the maximal length measurable in any direction for bile duct structures, and the proliferation, but not for any type of diameter. The normal portal plate was different from the portal plate of children with biliary atresia by always having 2 large biliary structures and the cells being mucinous and columnar in the largest bile ducts. Only 1 of 4 normal portal plates showed signs of proliferation. There was no significant difference between the normal and the success group with respect to the number, maximal length, and proliferation of the bile ducts. A difference in the diameter between the normal group and the entire EHBA group was significant for the maximal internal diameter but not for the other types of diameter measurements. CONCLUSION: The present study shows the following:

U2 - 10.1016/j.jpedsurg.2008.11.054

DO - 10.1016/j.jpedsurg.2008.11.054

M3 - Journal article

C2 - 19573659

SN - 0022-3468

VL - 44

SP - 1344

EP - 1348

JO - Journal of Pediatric Surgery

JF - Journal of Pediatric Surgery

IS - 7

ER -