HIV and risk of venous thromboembolism: a Danish nationwide population-based cohort study

Ld Rasmussen; M Dybdal; J Gerstoft; G Kronborg; Cs Larsen; C Pedersen; G Pedersen; J Jensen; L Pedersen; Ht Sørensen; N Obel; Jan Gerstoft; Niels Obel

doi:10.1111/j.1468-1293.2010.00869.x

HIV and risk of venous thromboembolism: a Danish nationwide population-based cohort study

Ld Rasmussen, M Dybdal, J Gerstoft, G Kronborg, Cs Larsen, C Pedersen, G Pedersen, J Jensen, L Pedersen, Ht Sørensen, N Obel, Jan Gerstoft, Niels Obel

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

56 Citationer (Scopus)

Abstract

Udgivelsesdato: 2011-Apr

Originalsprog	Engelsk
Tidsskrift	HIV Medicine
Vol/bind	12
Udgave nummer	4
Sider (fra-til)	202-210
Antal sider	8
ISSN	1464-2662
DOI	https://doi.org/10.1111/j.1468-1293.2010.00869.x
Status	Udgivet - 2010

Bibliografisk note

Adgang til dokumentet

10.1111/j.1468-1293.2010.00869.x

Citationsformater

@article{96790457e6424ec2aa418ef8eaad7447,

title = "HIV and risk of venous thromboembolism: a Danish nationwide population-based cohort study",

abstract = "OBJECTIVE: The association between HIV infection and the risk of venous thromboembolism (VTE) is controversial. We examined the risk of VTE in HIV-infected individuals compared with the general population and estimated the impact of low CD4 cell count, highly active antiretroviral therapy (HAART) and injecting drug use (IDU). METHODS: We identified 4333 Danish HIV-infected patients from the Danish HIV Cohort Study and a population-based age- and gender-matched comparison cohort of 43 330 individuals. VTE diagnoses were extracted from the Danish National Hospital Registry. Cumulative incidence curves were constructed for time to first VTE. Incidence rate ratios (IRRs) and impact of low CD4 cell count and HAART were estimated by Cox regression analyses. Analyses were stratified by IDU, adjusted for comorbidity and disaggregated by overall, provoked and unprovoked VTE. RESULTS: The 5-year risk of VTE was 8.0% [95% confidence interval (CI) 5.78-10.74%] in IDU HIV-infected patients, 1.5% (95% CI 1.14-1.95%) in non-IDU HIV-infected patients and 0.3% (95% CI 0.29-0.41%) in the population comparison cohort. In non-IDU HIV-infected patients, adjusted IRRs for unprovoked and provoked VTE were 3.42 (95% CI 2.58-4.54) and 5.51 (95% CI 3.29-9.23), respectively, compared with the population comparison cohort. In IDU HIV-infected patients, the adjusted IRRs were 12.66 (95% CI 6.03-26.59) for unprovoked VTE and 9.38 (95% CI 1.61-54.50) for provoked VTE. Low CD4 cell count had a minor impact on these risk estimates, while HAART increased the overall risk (IRR 1.93; 95% CI 1.00-3.72). CONCLUSION: HIV-infected patients are at increased risk of VTE, especially in the IDU population. HAART and possibly low CD4 cell count further increase the risk.",

author = "Ld Rasmussen and M Dybdal and J Gerstoft and G Kronborg and Cs Larsen and C Pedersen and G Pedersen and J Jensen and L Pedersen and Ht S{\o}rensen and N Obel and Jan Gerstoft and Niels Obel",

note = "{\textcopyright} 2010 British HIV Association.",

year = "2010",

doi = "10.1111/j.1468-1293.2010.00869.x",

language = "English",

volume = "12",

pages = "202--210",

journal = "HIV Medicine",

issn = "1464-2662",

publisher = "Wiley-Blackwell",

number = "4",

}

TY - JOUR

T1 - HIV and risk of venous thromboembolism: a Danish nationwide population-based cohort study

AU - Rasmussen, Ld

AU - Dybdal, M

AU - Gerstoft, J

AU - Kronborg, G

AU - Larsen, Cs

AU - Pedersen, C

AU - Pedersen, G

AU - Jensen, J

AU - Pedersen, L

AU - Sørensen, Ht

AU - Obel, N

AU - Gerstoft, Jan

AU - Obel, Niels

PY - 2010

Y1 - 2010

N2 - OBJECTIVE: The association between HIV infection and the risk of venous thromboembolism (VTE) is controversial. We examined the risk of VTE in HIV-infected individuals compared with the general population and estimated the impact of low CD4 cell count, highly active antiretroviral therapy (HAART) and injecting drug use (IDU). METHODS: We identified 4333 Danish HIV-infected patients from the Danish HIV Cohort Study and a population-based age- and gender-matched comparison cohort of 43 330 individuals. VTE diagnoses were extracted from the Danish National Hospital Registry. Cumulative incidence curves were constructed for time to first VTE. Incidence rate ratios (IRRs) and impact of low CD4 cell count and HAART were estimated by Cox regression analyses. Analyses were stratified by IDU, adjusted for comorbidity and disaggregated by overall, provoked and unprovoked VTE. RESULTS: The 5-year risk of VTE was 8.0% [95% confidence interval (CI) 5.78-10.74%] in IDU HIV-infected patients, 1.5% (95% CI 1.14-1.95%) in non-IDU HIV-infected patients and 0.3% (95% CI 0.29-0.41%) in the population comparison cohort. In non-IDU HIV-infected patients, adjusted IRRs for unprovoked and provoked VTE were 3.42 (95% CI 2.58-4.54) and 5.51 (95% CI 3.29-9.23), respectively, compared with the population comparison cohort. In IDU HIV-infected patients, the adjusted IRRs were 12.66 (95% CI 6.03-26.59) for unprovoked VTE and 9.38 (95% CI 1.61-54.50) for provoked VTE. Low CD4 cell count had a minor impact on these risk estimates, while HAART increased the overall risk (IRR 1.93; 95% CI 1.00-3.72). CONCLUSION: HIV-infected patients are at increased risk of VTE, especially in the IDU population. HAART and possibly low CD4 cell count further increase the risk.

AB - OBJECTIVE: The association between HIV infection and the risk of venous thromboembolism (VTE) is controversial. We examined the risk of VTE in HIV-infected individuals compared with the general population and estimated the impact of low CD4 cell count, highly active antiretroviral therapy (HAART) and injecting drug use (IDU). METHODS: We identified 4333 Danish HIV-infected patients from the Danish HIV Cohort Study and a population-based age- and gender-matched comparison cohort of 43 330 individuals. VTE diagnoses were extracted from the Danish National Hospital Registry. Cumulative incidence curves were constructed for time to first VTE. Incidence rate ratios (IRRs) and impact of low CD4 cell count and HAART were estimated by Cox regression analyses. Analyses were stratified by IDU, adjusted for comorbidity and disaggregated by overall, provoked and unprovoked VTE. RESULTS: The 5-year risk of VTE was 8.0% [95% confidence interval (CI) 5.78-10.74%] in IDU HIV-infected patients, 1.5% (95% CI 1.14-1.95%) in non-IDU HIV-infected patients and 0.3% (95% CI 0.29-0.41%) in the population comparison cohort. In non-IDU HIV-infected patients, adjusted IRRs for unprovoked and provoked VTE were 3.42 (95% CI 2.58-4.54) and 5.51 (95% CI 3.29-9.23), respectively, compared with the population comparison cohort. In IDU HIV-infected patients, the adjusted IRRs were 12.66 (95% CI 6.03-26.59) for unprovoked VTE and 9.38 (95% CI 1.61-54.50) for provoked VTE. Low CD4 cell count had a minor impact on these risk estimates, while HAART increased the overall risk (IRR 1.93; 95% CI 1.00-3.72). CONCLUSION: HIV-infected patients are at increased risk of VTE, especially in the IDU population. HAART and possibly low CD4 cell count further increase the risk.

U2 - 10.1111/j.1468-1293.2010.00869.x

DO - 10.1111/j.1468-1293.2010.00869.x

M3 - Journal article

SN - 1464-2662

VL - 12

SP - 202

EP - 210

JO - HIV Medicine

JF - HIV Medicine

IS - 4

ER -