Household transmission of the SARS-CoV-2 Omicron variant in Denmark

Frederik Plesner Lyngse; Laust Hvas Mortensen; Matthew J Denwood; Lasse Engbo Christiansen; Camilla Holten Møller; Robert Leo Skov; Katja Spiess; Anders Fomsgaard; Ria Lassaunière; Morten Rasmussen; Marc Stegger; Claus Nielsen; Raphael Niklaus Sieber; Arieh Sierra Cohen; Frederik Trier Møller; Maria Overvad; Kåre Mølbak; Tyra Grove Krause; Carsten Thure Kirkeby

doi:10.1038/s41467-022-33328-3

Household transmission of the SARS-CoV-2 Omicron variant in Denmark

Frederik Plesner Lyngse, Laust Hvas Mortensen, Matthew J Denwood, Lasse Engbo Christiansen, Camilla Holten Møller, Robert Leo Skov, Katja Spiess, Anders Fomsgaard, Ria Lassaunière, Morten Rasmussen, Marc Stegger, Claus Nielsen, Raphael Niklaus Sieber, Arieh Sierra Cohen, Frederik Trier Møller, Maria Overvad, Kåre Mølbak, Tyra Grove Krause, Carsten Thure Kirkeby

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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Abstract

In late 2021, the Omicron SARS-CoV-2 variant overtook the previously dominant Delta variant, but the extent to which this transition was driven by immune evasion or a change in the inherent transmissibility is currently unclear. We estimate SARS-CoV-2 transmission within Danish households during December 2021. Among 26,675 households (8,568 with the Omicron VOC), we identified 14,140 secondary infections within a 1-7-day follow-up period. The secondary attack rate was 29% and 21% in households infected with Omicron and Delta, respectively. For Omicron, the odds of infection were 1.10 (95%-CI: 1.00-1.21) times higher for unvaccinated, 2.38 (95%-CI: 2.23-2.54) times higher for fully vaccinated and 3.20 (95%-CI: 2.67-3.83) times higher for booster-vaccinated contacts compared to Delta. We conclude that the transition from Delta to Omicron VOC was primarily driven by immune evasiveness and to a lesser extent an inherent increase in the basic transmissibility of the Omicron variant.

Originalsprog	Engelsk
Artikelnummer	5573
Tidsskrift	Nature Communications
Vol/bind	13
ISSN	2041-1723
DOI	https://doi.org/10.1038/s41467-022-33328-3
Status	Udgivet - 2022

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10.1038/s41467-022-33328-3Licens: CC BY

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Citationsformater

Lyngse, F. P., Mortensen, L. H., Denwood, M. J., Christiansen, L. E., Møller, C. H., Skov, R. L., Spiess, K., Fomsgaard, A., Lassaunière, R., Rasmussen, M., Stegger, M., Nielsen, C., Sieber, R. N., Cohen, A. S., Møller, F. T., Overvad, M., Mølbak, K., Krause, T. G., & Kirkeby, C. T. (2022). Household transmission of the SARS-CoV-2 Omicron variant in Denmark. Nature Communications, 13, [5573]. https://doi.org/10.1038/s41467-022-33328-3

Household transmission of the SARS-CoV-2 Omicron variant in Denmark. / Lyngse, Frederik Plesner ; Mortensen, Laust Hvas ; Denwood, Matthew J; Christiansen, Lasse Engbo; Møller, Camilla Holten; Skov, Robert Leo; Spiess, Katja; Fomsgaard, Anders; Lassaunière, Ria; Rasmussen, Morten; Stegger, Marc; Nielsen, Claus; Sieber, Raphael Niklaus; Cohen, Arieh Sierra; Møller, Frederik Trier; Overvad, Maria; Mølbak, Kåre ; Krause, Tyra Grove ; Kirkeby, Carsten Thure.

I: Nature Communications, Bind 13, 5573, 2022.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Lyngse, FP , Mortensen, LH , Denwood, MJ, Christiansen, LE, Møller, CH, Skov, RL, Spiess, K, Fomsgaard, A, Lassaunière, R, Rasmussen, M, Stegger, M, Nielsen, C, Sieber, RN, Cohen, AS, Møller, FT, Overvad, M, Mølbak, K , Krause, TG & Kirkeby, CT 2022, 'Household transmission of the SARS-CoV-2 Omicron variant in Denmark', Nature Communications, bind 13, 5573. https://doi.org/10.1038/s41467-022-33328-3

Lyngse, Frederik Plesner ; Mortensen, Laust Hvas ; Denwood, Matthew J ; Christiansen, Lasse Engbo ; Møller, Camilla Holten ; Skov, Robert Leo ; Spiess, Katja ; Fomsgaard, Anders ; Lassaunière, Ria ; Rasmussen, Morten ; Stegger, Marc ; Nielsen, Claus ; Sieber, Raphael Niklaus ; Cohen, Arieh Sierra ; Møller, Frederik Trier ; Overvad, Maria ; Mølbak, Kåre ; Krause, Tyra Grove ; Kirkeby, Carsten Thure. / Household transmission of the SARS-CoV-2 Omicron variant in Denmark. I: Nature Communications. 2022 ; Bind 13.

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abstract = "In late 2021, the Omicron SARS-CoV-2 variant overtook the previously dominant Delta variant, but the extent to which this transition was driven by immune evasion or a change in the inherent transmissibility is currently unclear. We estimate SARS-CoV-2 transmission within Danish households during December 2021. Among 26,675 households (8,568 with the Omicron VOC), we identified 14,140 secondary infections within a 1-7-day follow-up period. The secondary attack rate was 29% and 21% in households infected with Omicron and Delta, respectively. For Omicron, the odds of infection were 1.10 (95%-CI: 1.00-1.21) times higher for unvaccinated, 2.38 (95%-CI: 2.23-2.54) times higher for fully vaccinated and 3.20 (95%-CI: 2.67-3.83) times higher for booster-vaccinated contacts compared to Delta. We conclude that the transition from Delta to Omicron VOC was primarily driven by immune evasiveness and to a lesser extent an inherent increase in the basic transmissibility of the Omicron variant.",

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