How Cells Respond to DNA Breaks in Mitosis

Andrew N Blackford, Manuel Stucki

Publikation: Bidrag til tidsskriftReviewForskningpeer review

49 Citationer (Scopus)

Abstract

DNA double-strand breaks (DSBs) are highly toxic lesions that can lead to chromosomal instability if they are not repaired correctly. DSBs are especially dangerous in mitosis when cells go through the complex process of equal chromosome segregation into daughter cells. When cells encounter DSBs in interphase, they are able to arrest the cell cycle until the breaks are repaired before entering mitosis. However, when DSBs occur during mitosis, cells no longer arrest but prioritize completion of cell division over repair of DNA damage. This review focuses on recent progress in our understanding of the mechanisms that allow mitotic cells to postpone DSB repair without accumulating massive chromosomal instability. Additionally, we review possible physiological consequences of failed DSB responses in mitosis.

OriginalsprogEngelsk
TidsskriftTrends in Biochemical Sciences
Vol/bind45
Udgave nummer4
Sider (fra-til)321-331
Antal sider11
ISSN0968-0004
DOI
StatusUdgivet - 2020
Udgivet eksterntJa

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